The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size
Open accessAbstract
Studies of Drosophila and mammals have revealed the importance of insulin signaling through phosphatidylinositol 3-kinase and the serine/threonine kinase Akt/protein kinase B for the regulation of cell, organ, and organismal growth. In mammals, three highly conserved proteins, Akt1, Akt2, and Akt3, comprise the Akt family, of which the first two are required for normal growth and metabolism, respectively. Here we address the function of Akt3. Like Akt1, Akt3 is not required for the maintenance of normal carbohydrate metabolism but is essential for the attainment of normal organ size. However, in contrast to Akt1-/- mice, which display a proportional decrease in the sizes of all organs, Akt3-/- mice present a selective 20% decrease in brain size. Moreover, although Akt1- and Akt3-deficient brains are reduced in size to approximately the same degree, the absence of Akt1 leads to a reduction in cell number, whereas the lack of Akt3 results in smaller and fewer cells. Finally, mammalian target of rapamycin signaling is attenuated in the brains of Akt3-/- but not Akt1-/- mice, suggesting that differential regulation of this pathway contributes to an isoform-specific regulation of cell growth.
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Cites
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BackgroundInfluentialProtein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth
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Cited by
AKT/PKB Signaling: Navigating the Network
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Akt signalling in health and disease
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FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes
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De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly
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Metadata
- Authors
- Easton, R. M., Cho, H., Roovers, K., Shineman, D. W., Mizrahi, M., Forman, M. S., Lee, V. M.-Y., Szabolcs, M., de Jong, R., Oltersdorf, T., Ludwig, T., Efstratiadis, A., & Birnbaum, M. J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2005-03-01
- Volume
- 25
- Issue
- 5
- Pages
- 1869-1878
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2131426434
- Cited by
- 551
- References
- 8
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Easton, R. M., Cho, H., Roovers, K., Shineman, D. W., Mizrahi, M., Forman, M. S., Lee, V. M.-Y., Szabolcs, M., de Jong, R., Oltersdorf, T., Ludwig, T., Efstratiadis, A., & Birnbaum, M. J. (2005). Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.25.5.1869-1878.2005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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