The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Regulation of PCNA and Cyclin D1 Expression and Epithelial Morphogenesis by the ZO-1-Regulated Transcription Factor ZONAB/DbpA
Open accessAbstract
The tight junction protein ZO-1 inhibits G1/S-phase transition by cytoplasmic sequestration of a complex formed by CDK4 and the transcription factor ZONAB. Canine ZONAB is the homologue of human DbpA, an E2F target gene that is overexpressed in different carcinomas. Since the ZONAB target genes that are involved in G1/S-phase transition are unknown, we employed the mammary epithelial cell line MCF-10A and cDNA arrays to screen for such genes. We identified genes encoding cell cycle and replication proteins whose expression was altered due to increased ZONAB expression. For proliferative cell nuclear antigen and cyclin D1 genes, we show that increased mRNA levels resulted in increased protein levels and we identified ZONAB-responsive elements in their promoters by using different approaches, including chromatin immunoprecipitation assays. RNA interference and overexpression of ZONAB affected the proliferation of both MCF-10A and MDCK cells as well as the differentiation of MDCK cells into polarized cysts in three-dimensional cultures. These results indicate that ZONAB regulates the transcription of genes that are important for G1/S-phase progression and links tight junctions to the transcriptional control of key cell cycle regulators and epithelial cell differentiation.
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Cites
Daro, E., van der Sluijs, P., Galli, T., & Mellman, I. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9559 · Cited by 343
Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts
Pagano, M., Theodoras, A. M., Tam, S. W., & Draetta, G. F. (1994) · Genes & Development · doi:10.1101/gad.8.14.1627 · Cited by 294
Establishment and Characterization of Cultured Epithelial Cells Lacking Expression of ZO-1
Umeda, K., Matsui, T., Nakayama, M., Furuse, K., Sasaki, H., Furuse, M., & Tsukita, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406563200 · Cited by 263
Aijaz, S., D’Atri, F., Citi, S., Balda, M. S., & Matter, K. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.003 · Cited by 226
Self-citationBainbridge, J., Stephens, C., Parsley, K., Demaison, C., Halfyard, A., Thrasher, A., & Ali, R. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301574 · Cited by 197
Self-citationWild-Type Human p53 Transactivates the Human Proliferating Cell Nuclear Antigen Promoter
Shivakumar, C. V., Brown, D. R., Deb, S., & Deb, S. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6785 · Cited by 120
Li, Y.-Y., Wang, L., & Lu, C.-D. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00485-x · Cited by 23
Cited by
ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation
Tornavaca, O., Chia, M., Dufton, N., Almagro, L. O., Conway, D. E., Randi, A. M., Schwartz, M. A., Matter, K., & Balda, M. S. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201404140 · Cited by 585
Self-citationTranscriptional regulation of the cyclin D1 gene at a glance
Klein, E. A., & Assoian, R. K. (2008) · Journal of Cell Science · doi:10.1242/jcs.039131 · Cited by 341
Epithelial cell–cell junctions and plasma membrane domains
Giepmans, B. N. G., & van IJzendoorn, S. C. D. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.07.015 · Cited by 170
The RAL Enigma: Distinct Roles of RALA and RALB in Cancer
Richardson, D. S., Spehar, J. M., Han, D. T., Chakravarthy, P. A., & Sizemore, S. T. (2022) · Cells · doi:10.3390/cells11101645 · Cited by 31
Metadata
- Authors
- Sourisseau, T., Georgiadis, A., Tsapara, A., Ali, R. R., Pestell, R., Matter, K., & Balda, M. S.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2006-03-01
- Volume
- 26
- Issue
- 6
- Pages
- 2387-2398
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2002675277
- Cited by
- 230
- References
- 7
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Sourisseau, T., Georgiadis, A., Tsapara, A., Ali, R. R., Pestell, R., Matter, K., & Balda, M. S. (2006). Regulation of PCNA and Cyclin D1 Expression and Epithelial Morphogenesis by the ZO-1-Regulated Transcription Factor ZONAB/DbpA. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.26.6.2387-2398.2006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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