Colorectal cancer: the facts in the case of the microbiota

Clay, Slater L.; Fonseca-Pereira, Diogo; Garrett, Wendy S.

doi:10.1172/jci155101

Cited by 166Gut microbiota and healthEscherichia coli research studiesCancer Research and Treatments

Colorectal cancer: the facts in the case of the microbiota

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Clay, Slater L., Fonseca-Pereira, Diogo, Garrett, Wendy S.·2022·Journal of Clinical Investigation

DOI 10.1172/jci155101PMC PMC8843708

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Abstract

The importance of the microbiota in the development of colorectal cancer (CRC) is increasingly evident, but identifying specific microbial features that influence CRC initiation and progression remains a central task for investigators. Studies determining the microbial mechanisms that directly contribute to CRC development or progression are revealing bacterial factors such as toxins that contribute to colorectal carcinogenesis. However, even when investigators have identified bacteria that express toxins, questions remain about the host determinants of a toxin's cancer-potentiating effects. For other cancer-correlating bacteria that lack toxins, the challenge is to define cancer-relevant virulence factors. Herein, we evaluate three CRC-correlating bacteria, colibactin-producing Escherichia coli, enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum, for their virulence features relevant to CRC. We also consider the beneficial bioactivity of gut microbes by highlighting a microbial metabolite that may enhance CRC antitumor immunity. In doing so, we aim to elucidate unique and shared mechanisms underlying the microbiota's contributions to CRC and to accelerate investigation from target validation to CRC therapeutic discovery.

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Fusobacterium nucleatum is often found in colorectal carcinoma tissues and reduces clinical response to chemotherapy.
“while Fusobacterium nucleatum is often found in colorectal carcinoma tissues and reduces the clinical response to chemotherapy.”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [96]

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Meta-hallmarks of aging and cancer
López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529 · see citing works

Authors: Clay, S. L., Fonseca-Pereira, D., & Garrett, W. S.
Affiliations: Harvard University (US)
Broad Institute (US)
Corresponding author: Garrett, Wendy S.
ORCID: Clay, Slater L.
Fonseca-Pereira, Diogo
Garrett, Wendy S.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2022-02-15
Volume: 132
Issue: 4
ISSN: 0021-9738 (ISSN-L)
1558-8238
DOI: 10.1172/jci155101
PMC: PMC8843708
OpenAlex: W4212788182
Cited by: 166
References: 124
Citations by year: 2026: 33 · 2025: 29 · 2024: 44 · 2023: 46 · 2022: 14
FWCI: 3.51
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Journal of Clinical Investigation (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Cancer Research UK (27140, #C10674/A27140, A27140)
National Institutes of Health
National Cancer Institute (T32CA207021, R01CA154426)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
Keywords: colorectal cancer, gut microbiota, colibactin, Escherichia coli, enterotoxigenic Bacteroides fragilis, Fusobacterium nucleatum, bacterial toxins, virulence factors, colorectal carcinogenesis, microbial metabolites, antitumor immunity, host-microbe interactions
MeSH terms: Gastrointestinal Microbiome, Animals, Bacteria, Humans, Colorectal Neoplasms, Carcinogenesis

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Colorectal cancer: the facts in the case of the microbiota

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