Diet rich in animal protein promotes pro-inflammatory macrophage response and exacerbates colitis in mice
Open accessAbstract
Diet is a major factor determining gut microbiota composition and perturbances in this complex ecosystem are associated with the inflammatory bowel disease (IBD). Here, we used gnotobiotic approach to analyze, how interaction between diet rich in proteins and gut microbiota influences the sensitivity to intestinal inflammation in murine model of ulcerative colitis. We found that diet rich in animal protein (aHPD) exacerbate acute dextran sulfate sodium (DSS)-induced colitis while diet rich in plant protein (pHPD) does not. The deleterious effect of aHPD was also apparent in chronic DSS colitis and was associated with distinct changes in gut bacteria and fungi. Therefore, we induced acute DSS-colitis in germ-free mice and transferred gut microbiota from aCD or aHPD fed mice to find that this effect requires presence of microbes and aHPD at the same time. The aHPD did not change the number of regulatory T cells or Th17 cells and still worsened the colitis in immuno-deficient RAG2 knock-out mice suggesting that this effect was not dependent on adaptive immunity. The proinflammatory effect of aHPD was, however, abrogated when splenic macrophages were depleted with clodronate liposomes. This treatment prevented aHPD induced increase in colonic Ly-6Chigh pro-inflammatory monocytes, but the ration of resident Ly-6C-/low macrophages was not changed. These data show that the interactions between dietary protein of animal origin and gut microbiota increases sensitivity to intestinal inflammation by promoting pro-inflammatory response of monocytes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In mice, animal-based protein increases potential detrimental gut microbes, and plant-based protein boosts the abundance of Bifidobacterium, Roseburia, and Lactobacillus and lowers the abundance of pathogens such as Bacteroides fragilis and Clostridium perfringens.
“In mice, animal-based protein increases potential detrimental gut microbes, e.g., Peptostreptococcaceae, Ruminococcaceae, Enterococcus, Streptococcus, Turicibacter, or Escherichia (92), and plant-based protein boosts the abundance of Bifidobacterium, Roseburia, and Lactobacillus and lowers the abundance of pathogens such as Bacteroides fragilis and Clostridium perfringens (37,42,80).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [92]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 19,770 · see citing works
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB
DeSantis, T. Z., Hugenholtz, P., Larsen, N., Rojas, M., Brodie, E. L., Keller, K., Huber, T., Dalevi, D., Hu, P., & Andersen, G. L. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.03006-05 · Cited by 10,891 · see citing works
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116 · see citing works
Klindworth, A., Pruesse, E., Schweer, T., Peplies, J., Quast, C., Horn, M., & Glöckner, F. O. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks808 · Cited by 8,850 · see citing works
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760 · see citing works
Okayasu, I., Hatakeyama, S., Yamada, M., Ohkusa, T., Inagaki, Y., & NAKAYA, R. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90290-h · Cited by 2,405 · see citing works
Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans
Muegge, B. D., Kuczynski, J., Knights, D., Clemente, J. C., González, A., Fontana, L., Henrissat, B., Knight, R., & Gordon, J. I. (2011) · Science · doi:10.1126/science.1198719 · Cited by 1,988 · see citing works
The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead
Kostic, A. D., Xavier, R. J., & Gevers, D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.009 · Cited by 1,789 · see citing works
Schwabe, R. F., & Jobin, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3610 · Cited by 1,689 · see citing works
Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Thaiss, C. A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A. C., Abramson, L., Katz, M. N., Korem, T., Zmora, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.048 · Cited by 1,449 · see citing works
Bengtsson‐Palme, J., Ryberg, M. K., Hartmann, M., Branco, S., Wang, Z., Godhe, A., Wit, P. D., Sánchez‐García, M., Ebersberger, I., Sousa, F., et al. (2013) · Methods in Ecology and Evolution · doi:10.1111/2041-210x.12073 · Cited by 1,399 · see citing works
Fungal microbiota dysbiosis in IBD
Sokol, H., Leducq, V., Aschard, H., Pham, H., Jégou, S., Landman, C., Cohen, D., Liguori, G., Bourrier, A., Nion–Larmurier, I., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310746 · Cited by 1,313 · see citing works
Topographic diversity of fungal and bacterial communities in human skin
NIH Intramural Sequencing Center Comparative Sequencing Program, Findley, K., Oh, J., Yang, J., Conlan, S., Deming, C., Meyer, J. A., Schoenfeld, D., Nomicos, E., Park, M., et al. (2013) · Nature · doi:10.1038/nature12171 · Cited by 1,206 · see citing works
Bacterial Secretion Systems: An Overview
Green, E. R., & Mecsas, J. C. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0012-2015 · Cited by 1,090 · see citing works
Th17 cell induction by adhesion of microbes to intestinal epithelial cells
Atarashi, K., Tanoue, T., Ando, M., Kamada, N., Nagano, Y., Narushima, S., Suda, W., Imaoka, A., Setoyama, H., Nagamori, T., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.058 · Cited by 1,071 · see citing works
The role of microbiome in central nervous system disorders
Wang, Y., & Kasper, L. H. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.015 · Cited by 803 · see citing works
Tlaskalová-Hogenová, H., Štěpánková, R., Kozáková, H., Hudcovic, T., Vannucci, L., Tučková, L., Rossmann, P., Hrnčíř, T., Kverka, M., Zákostelská, Z., et al. (2011) · Cellular & Molecular Immunology · doi:10.1038/cmi.2010.67 · Cited by 693 · see citing works
Self-citationRelevance of protein fermentation to gut health
Windey, K., De Preter, V., & Verbeke, K. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100542 · Cited by 692 · see citing works
Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice
Dieleman, L. A., Ridwan, B. U., Tennyson, G. S., Beagley, K. W., Bucy, R. P., & Elson, C. O. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90803-6 · Cited by 677 · see citing works
The contributory role of gut microbiota in cardiovascular disease
Tang, W. H. W., & Hazen, S. L. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72331 · Cited by 641 · see citing works
Adherent-invasive Escherichia coli in inflammatory bowel disease
Palmela, C., Chevarin, C., Xu, Z., Torres, J., Sevrin, G., Hirten, R. P., Barnich, N., Ng, S. C., & Colombel, J. (2017) · Gut · doi:10.1136/gutjnl-2017-314903 · Cited by 541 · see citing works
Shoda, R., Matsueda, K., Yamato, S., & Umeda, N. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.5.741 · Cited by 444 · see citing works
The liposome-mediated macrophage ‘suicide’ technique
van Rooijen, N. (1989) · Journal of Immunological Methods · doi:10.1016/0022-1759(89)90178-6 · Cited by 438 · see citing works
Llewellyn, S. R., Britton, G. J., Contijoch, E. J., Vennaro, O. H., Mortha, A., Colombel, J.-F., Grinspan, A., Clemente, J. C., Merad, M., & Faith, J. J. (2018) · Gastroenterology · doi:10.1053/j.gastro.2017.11.030 · Cited by 364 · see citing works
Bajer, L., Kverka, M., Kostovčík, M., Mačinga, P., Dvořák, J., Stehlíková, Z., Březina, J., Wohl, P., Špičák, J., & Drastich, P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i25.4548 · Cited by 360 · see citing works
Self-citationOrigin, Differentiation, and Function of Intestinal Macrophages
Bain, C. C., & Schridde, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02733 · Cited by 348 · see citing works
Relationship of Diet to Risk of Colorectal Adenoma in Men
Giovannucci, E. L., Stampfer, M. J., Colditz, G. A., Rimm, E. B., & Willett, W. C. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.2.91 · Cited by 341 · see citing works
Kverka, M., Zakostelska, Z. J., Klimešová, K. (., Sokol, D., Hudcovic, T., Hrnčíř, T., Rossmann, P., Mrázek, J., Kopečný, J., Verdu, E. F., et al. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04286.x · Cited by 337 · see citing works
Self-citationVieira, E. L. M., Leonel, A. J., Sad, A. P., Beltrão, N. R. M., Costa, T. F., Ferreira, T. M. R., Gomes-Santos, A. C., Faria, A. M. C., Peluzio, M. C. G., Cara, D. C., et al. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.01.007 · Cited by 290 · see citing works
Changes in Colonic Mucosal Permeability in Mouse Colitis Induced with Dextran Sulfate Sodium.
Kitajima, S., TAKUMA, S., & MORIMOTO, M. (1999) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.48.137 · Cited by 283 · see citing works
Macfarlane, G. T., Gibson, G. R., Beatty, E. R., & Cummings, J. H. (1992) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1992.tb05764.x · Cited by 255 · see citing works
Beaumont, M., Portune, K. J., Steuer, N., Lan, A., Cerrudo, V., Audebert, M., Dumont, F., Mancano, G., Khodorova, N., Andriamihaja, M., et al. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.158816 · Cited by 250 · see citing works
Suppression of experimental colitis by intestinal mononuclear phagocytes
Qualls, J. E., Kaplan, A. M., van Rooijen, N., & Cohen, D. A. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1205734 · Cited by 237 · see citing works
Diet and Inflammatory Bowel Disease: A Case-Control Study
Persson, P.-G., Ahlbom, A., & Hellers, G. (1992) · Epidemiology · doi:10.1097/00001648-199201000-00009 · Cited by 236 · see citing works
Spangler, J. B., Tomala, J., Luca, V. C., Jude, K. M., Dong, S., Ring, A. M., Votavová, P., Pepper, M., Kovář, M., & García, K. C. (2015) · Immunity · doi:10.1016/j.immuni.2015.04.015 · Cited by 217 · see citing works
Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice
Sánchez‐Fidalgo, S., Cárdeno, A., Villegas, I., Talero, E., & Alarcón‐de‐la‐Lastra, C. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.01.025 · Cited by 217 · see citing works
Effect of proteins from different sources on body composition
Gilbert, J.-A., Bendsen, N. T., Tremblay, A., & Astrup, A. (2011) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.12.008 · Cited by 207 · see citing works
An Independent Subset of TLR Expressing CCR2-Dependent Macrophages Promotes Colonic Inflammation
Platt, A. M., Bain, C. C., Bordon, Y., Sester, D. P., & Mowat, A. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903987 · Cited by 207 · see citing works
Kim, M., Galan, C., Hill, A. A., Wu, W.-J., Fehlner-Peach, H., Song, H. W., Schady, D., Bettini, M. L., Simpson, K. W., Longman, R. S., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.009 · Cited by 202 · see citing works
Zakostelska, Z. J., Kverka, M., Kostovcikova, K., Rossmann, P., Mrázek, J., Kopečný, J., Hornová, M., Šrůtková, D., Hudcovic, T., Rídl, J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027961 · Cited by 201 · see citing works
Self-citationSeril, D. N., Liao, J., Ho, K.-L. K., Warsi, A., Yang, C. S., & Yang, G.-Y. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1015362228659 · Cited by 183 · see citing works
Enterobacteriaceae are essential for the modulation of colitis severity by fungi
Sovran, B., Planchais, J., Jégou, S., Straube, M., Lamas, B., Natividad, J. M., Agus, A., Dupraz, L., Glodt, J., Costa, G. D., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0538-9 · Cited by 181 · see citing works
Dietary Factors: Major Regulators of the Gut's Microbiota
Moschen, A. R., Wieser, V., & Tilg, H. (2012) · Gut and Liver · doi:10.5009/gnl.2012.6.4.411 · Cited by 173 · see citing works
Dynamics of Colon Monocyte and Macrophage Activation During Colitis
Jones, G., Bain, C. C., Fenton, T. M., Kelly, A., Brown, S. L., Ivens, A. C., Travis, M. A., Cook, P. C., & MacDonald, A. S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02764 · Cited by 162 · see citing works
Constante, M., Fragoso, G., Calvé, A., Samba-Mondonga, M., & Santos, M. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01809 · Cited by 161 · see citing works
Fukuda, H., Mizuta, Y., Isomoto, H., Takeshima, F., Ohnita, K., Ohba, K., Omagari, K., Taniyama, K., & KOHNO, S. (2004) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520410007908 · Cited by 157 · see citing works
Bacterial Secretion Systems: An Overview
Green, E. R., & Mecsas, J. C. (2016) · ASM Press eBooks · doi:10.1128/9781555819286.ch8 · Cited by 151 · see citing works
Andriamihaja, M., Davila, A., Eklou-Lawson, M., Petit, N., Delpal, S., Allek, F., Blais, A., Delteil, C., Tomé, D., & Blachier, F. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00149.2010 · Cited by 145 · see citing works
Blachier, F., Beaumont, M., Andriamihaja, M., Davila, A., Lan, A., Grauso, M., Armand, L., Benamouzig, R., & Tomé, D. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.11.015 · Cited by 131 · see citing works
Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice
Liu, B., Lin, Q., Yang, T., et al. (2015) · Food & Function · doi:10.1039/c5fo00563a · Cited by 121 · see citing works
Maconi, G. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i34.4297 · Cited by 118 · see citing works
Spooren, C. E. G. M., Pierik, M. J., Zeegers, M. P., Feskens, E. J. M., Masclee, A., & Jonkers, D. M. A. E. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12501 · Cited by 110 · see citing works
Miles, J. P., Zou, J., Kumar, M.-V., Pellizzon, M., Ulman, E. A., Ricci, M. R., Gewirtz, A. T., & Chassaing, B. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001155 · Cited by 110 · see citing works
Opstelten, J. L., de Vries, J. H. M., Wools, A., Siersema, P. D., Oldenburg, B., & Witteman, B. J. M. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.06.983 · Cited by 108 · see citing works
Seo, D. H., Che, X., Kwak, M. S., Kim, S., Kim, J. H., Ma, H. W., Kim, D. H., Kim, T. I., Kim, W. H., Kim, S. W., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00840-2 · Cited by 107 · see citing works
Liu, X., Blouin, J.-M., Santacruz, A., Lan, A., Andriamihaja, M., Wilkanowicz, S., Benetti, P.-H., Tomé, D., Sanz, Y., Blachier, F., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00400.2013 · Cited by 103 · see citing works
Hudcovic, T., Štëpánková, R., Cebra, J. J., & Tlaskalová-Hogenová, H. (2001) · Folia Microbiologica · doi:10.1007/bf02818004 · Cited by 99 · see citing works
Self-citationOral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis
Klimesova, K., Jiraskova Zakostelska, Z., & Tlaskalova-Hogenova, H. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00774 · Cited by 67 · see citing works
The role of the calcium-sensing receptor in gastrointestinal inflammation
Owen, J. L., Cheng, S. X., Ge, Y., Sahay, B., & Mohamadzadeh, M. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.10.040 · Cited by 61 · see citing works
Lan, A., Andriamihaja, M., Blouin, J.-M., Liu, X., Descatoire, V., Desclée de Maredsous, C., Davila, A.-M., Walker, F., Tomé, D., & Blachier, F. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.09.007 · Cited by 57 · see citing works
Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes
Couter, C. J., & Surana, N. K. (2016) · Journal of Visualized Experiments · doi:10.3791/54114 · Cited by 56 · see citing works
Jubelin, G., Desvaux, M., Schüller, S., Etienne‐Mesmin, L., Muniesa, M., & Blanquet‐Diot, S. (2018) · Microorganisms · doi:10.3390/microorganisms6040115 · Cited by 54 · see citing works
Gut Microbiota Drives Metabolic Disease in Immunologically Altered Mice
Chassaing, B., Aitken, J. D., Gewirtz, A. T., & Vijay–Kumar, M. (2012) · Advances in immunology · doi:10.1016/b978-0-12-394300-2.00003-x · Cited by 49 · see citing works
Gong, Z., Yuan, Z., Dong, Z., & Peng, Y. (2017) · Europe PMC (PubMed Central) · Cited by 40 · see citing works
L-Threonine Supplementation During Colitis Onset Delays Disease Recovery
Gaifem, J., Gonçalves, L. G., Dinis‐Oliveira, R. J., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01247 · Cited by 29 · see citing works
Dual effects of a high-protein diet on DSS-treated mice during colitis resolution phase
Lan, A., Blais, A., Coelho, D., Capron, J., Maarouf, M., Benamouzig, R., Lancha, A. H., Walker, F., Tomé, D., & Blachier, F. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00433.2015 · Cited by 20 · see citing works
Tak, K.-H., Ahn, E., & Kim, E. (2017) · Nutrition Research and Practice · doi:10.4162/nrp.2017.11.4.281 · Cited by 16 · see citing works
Roche-Lima, A., Carrasquillo-Carrión, K., Gómez‐Moreno, R., Cruz, J. M., Velázquez-Morales, D. M., Rogozin, I. B., & Baerga‐Ortiz, A. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00116 · Cited by 16 · see citing works
Role of Dietary Metabolites in Regulating the Host Immune Response in Gastrointestinal Disease
Zaatari, M. E., & Kao, J. Y. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00051 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Leveraging diet to engineer the gut microbiome
Wolter, M., Grant, E. T., Boudaud, M., Steimle, A., Pereira, G. V., Martens, E. C., & Desai, M. S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00512-7 · Cited by 211 · see citing works
Fajstova, A., Galanova, N., Coufal, S., Malkova, J., Kostovcik, M., Cermakova, M., Pelantova, H., Kuzma, M., Sediva, B., Hudcovic, T., et al. (2020) · Cells · doi:10.3390/cells9122701 · Cited by 90 · see citing works
Self-citationCheng, Y., Zheng, G., Song, Z., Zhang, G., Rao, X., & Zeng, T. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1408424 · Cited by 16 · see citing works
- Authors
- Kostovcikova, K., Coufal, S., Galanova, N., Fajstova, A., Hudcovic, T., Kostovcik, M., Prochazkova, P., Jiraskova Zakostelska, Z., Cermakova, M., Sediva, B., Kuzma, M., Tlaskalova-Hogenova, H., & Kverka, M.
- Affiliations
- Czech Academy of Sciences (CZ)
- Corresponding author
- Kverka, Miloslav
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-04-26
- Volume
- 10
- Pages
- 919-919
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC6497971
- OpenAlex
- W2940891270
- Cited by
- 126
- References
- 76
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 17 · 2023: 17 · 2022: 20 · 2021: 19 · 2020: 16 · 2019: 1 · 2018: 1
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Digital Library (University of West Bohemia) (submittedVersion)
- Funders
- Grantová Agentura České Republiky (16-06326S, 17-06632Y)
- Ministerstvo Školství, Mládeže a Tělovýchovy (LO1509)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- animal protein diet, plant protein diets, gut microbiota, ulcerative colitis, DSS-induced colitis, inflammatory macrophages, monocyte polarization, inflammatory bowel disease, germ-free mice, fungal microbiota, innate immunity
- MeSH terms
- Gastrointestinal Microbiome, Animals, Colitis, Colon, Diet, Dietary Proteins, Disease Models, Animal, DNA-Binding Proteins, Female, Inflammation, Intestines, Macrophages, Mice, Inbred BALB C, Monocytes, Mice, Knockout, T-Lymphocytes, Regulatory, Mice, Adaptive Immunity, Th17 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
