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Gut Microbiota and Colonization Resistance against Bacterial Enteric Infection
Open accessAbstract
The gut microbiome is critical in providing resistance against colonization by exogenous microorganisms. The mechanisms via which the gut microbiota provide colonization resistance (CR) have not been fully elucidated, but they include secretion of antimicrobial products, nutrient competition, support of gut barrier integrity, and bacteriophage deployment.
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“The gut microbiota protects against intestinal colonization by pathogens via colonization resistance through both direct and indirect mechanisms.”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [33]
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“Examples of direct mechanisms of colonization resistance include nutrient competition between gut commensals and pathogens, production of inhibitory metabolites by gut commensals, production of bacteriocins by gut commensals, and the presence of bacteriophages [33, 34].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [33]
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Xu, J., Zhang, Y., Fang, X.-H., Liu, Y., Huang, Y.-B., Ke, Z.-L., Wang, Y., Zhang, Y. Y., Zhang, Y., Zhou, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26637837
Fu, Y., Zhang, K., Shan, F., Li, J., Wang, Y., Li, X., Xu, H., Qin, Z., & Zhang, L. (2024) · Figshare · doi:10.6084/m9.figshare.26630929
Aljahdali, N. H., Sanad, Y. M., Han, J., & Foley, S. L. (2020) · Figshare · doi:10.6084/m9.figshare.13250814
Metadata
- Authors
- Ducarmon, Q. R., Zwittink, R. D., Hornung, B. V. H., van Schaik, W., Young, V. B., & Kuijper, E. J.
- Affiliations
- Leiden University Medical Center (NL)
- Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom
- University of Michigan (US)
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2019-08-21
- Volume
- 83
- Issue
- 3
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- PMC
- PMC6710460
- OpenAlex
- W2948451181
- Cited by
- 566
- References
- 288
- Citations by year
- 2026: 81 · 2025: 86 · 2024: 109 · 2023: 99 · 2022: 71 · 2021: 67 · 2020: 48 · 2019: 4
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Microbiology and Molecular Biology Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Funders
- Royal Society Wolfson Research Merit Award (WM160092)
- Vedanta Biosciences Inc. (Unrestricted)
- HHS | National Institutes of Health (AI124255)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, colonization resistance, enteric bacterial infection, antimicrobial peptides, nutrient competition, intestinal barrier integrity, bacteriophages, host-microbe interactions
- MeSH terms
- Gastrointestinal Microbiome, Animals, Anti-Infective Agents, Bacteria, Bacterial Infections, Fatty Acids, Volatile, Humans, Mucus, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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