The DOI matches its Crossref record; 181 of the 181 references it cites were found in a registry or an index.
RecBCD Enzyme and the Repair of Double-Stranded DNA Breaks
Open accessAbstract
SUMMARY: The RecBCD enzyme of Escherichia coli is a helicase-nuclease that initiates the repair of double-stranded DNA breaks by homologous recombination. It also degrades linear double-stranded DNA, protecting the bacteria from phages and extraneous chromosomal DNA. The RecBCD enzyme is, however, regulated by a cis-acting DNA sequence known as Chi (crossover hotspot instigator) that activates its recombination-promoting functions. Interaction with Chi causes an attenuation of the RecBCD enzyme's vigorous nuclease activity, switches the polarity of the attenuated nuclease activity to the 5′ strand, changes the operation of its motor subunits, and instructs the enzyme to begin loading the RecA protein onto the resultant Chi-containing single-stranded DNA. This enzyme is a prototypical example of a molecular machine: the protein architecture incorporates several autonomous functional domains that interact with each other to produce a complex, sequence-regulated, DNA-processing machine. In this review, we discuss the biochemical mechanism of the RecBCD enzyme with particular emphasis on new developments relating to the enzyme's structure and DNA translocation mechanism.
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Self-citationBiochemistry of homologous recombination in Escherichia coli
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Metadata
- Authors
- Dillingham, M. S., & Kowalczykowski, S. C.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2008-12
- Volume
- 72
- Issue
- 4
- Pages
- 642-671
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- OpenAlex
- W2145532900
- Cited by
- 586
- References
- 181
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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