Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis

Jansen, J. G. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki189 · Cited by 86

Efficiency, specificity and DNA polymerase-dependence of translesion replication across the oxidative DNA lesion 8-oxoguanine in human cells

Avkin, S., & Livneh, Z. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00254-3 · Cited by 84

Expression of human and mouse genes encoding polκ: testis‐specific developmental regulation and AhR‐dependent inducible transcription

Ogi, T., Mimura, J., Hikida, M., Fujimoto, H., Fujii‐Kuriyama, Y., & Ohmori, H. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00478.x · Cited by 84

RAD18‐independent ubiquitination of proliferating‐cell nuclear antigen in the avian cell line DT40

Simpson, L. J., Ross, A.-L., Szüts, D., Alviani, C. A., Oestergaard, V. H., Patel, K. J., & Sale, J. E. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400777 · Cited by 84

Rad6-Rad18 Mediates a Eukaryotic SOS Response by Ubiquitinating the 9-1-1 Checkpoint Clamp

Fu, Y. V., Zhu, Y. B., Zhang, K., Yeung, M., Durocher, D., & Xiao, W. (2008) · Cell · doi:10.1016/j.cell.2008.02.050 · Cited by 83

Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.

Nelson, K. K., Schlöndorff, J. S., & Blobel, C. (1999) · PubMed Central · Cited by 83

ATR Homolog Mec1 Controls Association of DNA Polymerase ζ-Rev1 Complex with Regions near a Double-Strand Break

Hirano, Y., & Sugimoto, K. (2006) · Current Biology · doi:10.1016/j.cub.2006.01.063 · Cited by 83

Up-Regulation of the Error-Prone DNA Polymerase κ Promotes Pleiotropic Genetic Alterations and Tumorigenesis

Bavoux, C., Leopoldino, A. M., Bergoglio, V., Wang, J. O., Ogi, T., Bieth, A., Judde, J., Pena, S. D. J., Poupon, M., Helleday, T., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.325.65.1 · Cited by 80

Localisation of human Y-family DNA polymerase κ: relationship to PCNA foci

Ogi, T., Kannouche, P. L., & Lehmann, A. R. (2004) · Journal of Cell Science · doi:10.1242/jcs.01603 · Cited by 79

DNA repair in antibody somatic hypermutation

Casali, P., Pál, Z., Xu, Z., & Zan, H. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.05.001 · Cited by 79

Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer

Rimkus, C., Friederichs, J., Rosenberg, R., Holzmann, B., Siewert, J., & Janssen, K. (2006) · International Journal of Cancer · doi:10.1002/ijc.22155 · Cited by 78

Roles of Saccharomyces cerevisiae DNA polymerases Pol and Pol in response to irradiation by simulated sunlight

Kozmin, S. G. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg489 · Cited by 78

Effect of Proliferating Cell Nuclear Antigen Ubiquitination and Chromatin Structure on the Dynamic Properties of the Y-family DNA Polymerases

Sabbioneda, S., Gourdin, A. M., Green, C., Zotter, A., Giglia‐Mari, G., Houtsmuller, A. B., Vermeulen, W., & Lehmann, A. R. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-07-0724 · Cited by 77

Impairment of MAD2B–PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas

Weterman, M. A. J., van Groningen, J. J. M., Tertoolen, L. G. J., & van Kessel, A. G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241304198 · Cited by 76

Replication Bypass of the Acrolein-Mediated Deoxyguanine DNA-Peptide Cross-Links by DNA Polymerases of the DinB Family

Minko, I. G., Yamanaka, K., Kozekov, I. D., Kozekova, A., Indiani, C., O’Donnell, M. E., Jiang, Q., Goodman, M. F., Rizzo, C. J., & Lloyd, R. S. (2008) · Chemical Research in Toxicology · doi:10.1021/tx800174a · Cited by 76

DNA Polymerase η Contributes to Strand Bias of Mutations of A versus T in Immunoglobulin Genes

Mayorov, V., Rogozin, I. B., Adkison, L. R., & Gearhart, P. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7781 · Cited by 75

A test for Fanconi's anemia

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The role of DNA polymerase η in UV mutational spectra

Choi, J., & Pfeifer, G. P. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.09.006 · Cited by 70

DNA binding properties of human DNA polymerase η: implications for fidelity and polymerase switching of translesion synthesis

Kusumoto, R., Masutani, C., Shimmyo, S., Iwai, S., & Hanaoka, F. (2004) · Genes to Cells · doi:10.1111/j.1365-2443.2004.00797.x · Cited by 69

Yeast Rev1 is cell cycle regulated, phosphorylated in response to DNA damage and its binding to chromosomes is dependent upon MEC1

Sabbioneda, S., Bortolomai, I., Giannattasio, M., Plevani, P., & Muzi-Falconi, M. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.09.002 · Cited by 65

Protein-Template-Directed Synthesis across an Acrolein-Derived DNA Adduct by Yeast Rev1 DNA Polymerase

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S., & Aggarwal, A. K. (2008) · Structure · doi:10.1016/j.str.2007.12.009 · Cited by 64

Localisation of human DNA polymerase κ to replication foci

Bergoglio, V., Bavoux, C., Verbiest, V. H. M., Hoffmann, J., & Cazaux, C. (2002) · Journal of Cell Science · doi:10.1242/jcs.00162 · Cited by 63

Human DNA Polymerases λ and β Show Different Efficiencies of Translesion DNA Synthesis past Abasic Sites and Alternative Mechanisms for Frameshift Generation

Blanca, G., Villani, G., Shevelev, I., Ramadan, K., Spadari, S., Hübscher, U., & Maga, G. (2004) · Biochemistry · doi:10.1021/bi049050x · Cited by 63

Requirements for the Interaction of Mouse Polκ with Ubiquitin and Its Biological Significance

Guo, C., Tang, T.-S., Bienko, M., Đikić, I., & Friedberg, E. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709275200 · Cited by 63

Human REV1 Modulates the Cytotoxicity and Mutagenicity of Cisplatin in Human Ovarian Carcinoma Cells

Lin, X., Okuda, T., Trang, J., & Howell, S. B. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.020446 · Cited by 61

A Single Domain in Human DNA Polymerase ι Mediates Interaction with PCNA: Implications for Translesion DNA Synthesis

Haracska, L., Acharya, N., Unk, I., Johnson, R. E., Hurwitz, J., Prakash, L., & Prakash, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.1183-1190.2005 · Cited by 60

Roles of RAD6 Epistasis Group Members in Spontaneous Polζ-Dependent Translesion Synthesis in Saccharomyces cerevisiae

Minesinger, B. K., & Jinks-Robertson, S. (2005) · Genetics · doi:10.1534/genetics.104.033894 · Cited by 60

The Mutational Specificity of the Dbh Lesion Bypass Polymerase and Its Implications

Potapova, O., Grindley, N. D. F., & Joyce, C. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202607200 · Cited by 59

Novel Role for the C Terminus of Saccharomyces cerevisiae Rev1 in Mediating Protein-Protein Interactions

D’Souza, S., & Walker, G. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00202-06 · Cited by 59

A human DNA polymerase η complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin‐bound fraction of cells undergoing replication fork arrest

Yuasa, M., Masutani, C., Hirano, A., Cohn, M. A., Yamaizumi, M., Nakatani, Y., & Hanaoka, F. (2006) · Genes to Cells · doi:10.1111/j.1365-2443.2006.00974.x · Cited by 58

The post-replication repair RAD18 and RAD6 genes are involved in the prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiae

de Padula, M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh831 · Cited by 57

Replication-dependent and -independent Responses of RAD18 to DNA Damage in Human Cells

Nakajima, S., Lan, L., Kanno, S., Usami, N., Kobayashi, K., Mori, M., Shiomi, T., & Yasui, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605545200 · Cited by 56

Complex Formation of Yeast Rev1 with DNA Polymerase η

Acharya, N., Haracska, L., Prakash, S., & Prakash, L. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01478-07 · Cited by 55

Translesion synthesis of 7,8-dihydro-8-oxo-2′-deoxyguanosine by DNA polymerase eta in vivo

Lee, D.-H., & Pfeifer, G. P. (2008) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2008.02.006 · Cited by 53

Suppression of hREV1 Expression Reduces the Rate at Which Human Ovarian Carcinoma Cells Acquire Resistance to Cisplatin

Okuda, T., Lin, X., Trang, J., & Howell, S. B. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.010579 · Cited by 53

UV Induces p21 Rapid Turnover Independently of Ubiquitin and Skp2

Lee, H., Zeng, S. X., & Lu, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605366200 · Cited by 52

Roles of the polymerase and BRCT domains of Rev1 protein in translesion DNA synthesis in yeast in vivo

Otsuka, C., Kunitomi, N., Iwai, S., Loakes, D., & Negishi, K. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.03.005 · Cited by 52

Genetic linkage between Polι deficiency and increased susceptibility to lung tumors in mice

Lee, G., & Matsushita, H. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00042.x · Cited by 51

Mutator effects of overproducing DNA polymerase η (Rad30) and its catalytically inactive variant in yeast

Pavlov, Y. I., Nguyen, D., & Kunkel, T. A. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00131-2 · Cited by 50

New Functions for Y Family Polymerases

Lehmann, A. R. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.10.021 · Cited by 49

Detection of messenger RNA from the isoleucine-valine operons of Salmonella typhimurium by heterologous DNA-RNA hybridization: Involvement of transfer RNA in transcriptional repression

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A new family of phosphotransferases related to P-type ATPases

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Upregulation of Error-Prone DNA Polymerases Beta and Kappa Slows Down Fork Progression Without Activating the Replication Checkpoint

Pillaire, M., Betous, R., Conti, C., Czaplicki, J., Pasero, P., Bensimon, A., Cazaux, C., & Hoffmann, J. (2007) · Cell Cycle · doi:10.4161/cc.6.4.3857 · Cited by 47

Saccharomyces cerevisiae Polymerase ζ Functions in Mitochondria

Zhang, H., Chatterjee, A., & Singh, K. K. (2006) · Genetics · doi:10.1534/genetics.105.051029 · Cited by 47

The Fanconi anemia pathway limits the severity of mutagenesis

Hinz, J. M., Nham, P. B., Salazar, E. P., & Thompson, L. H. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.039 · Cited by 47

Rev7/MAD2B Links c-Jun N-Terminal Protein Kinase Pathway Signaling to Activation of the Transcription Factor Elk-1

Zhang, L., Yang, S., & Sharrocks, A. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02276-06 · Cited by 47

DNA Polymerase ζ Accounts for the Reduced Cytotoxicity and Enhanced Mutagenicity of Cisplatin in Human Colon Carcinoma Cells That Have Lost DNA Mismatch Repair

Lin, X., Trang, J., Okuda, T., & Howell, S. B. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1380 · Cited by 46

Comparative analysis of in vivo interactions between Rev1 protein and other Y-family DNA polymerases in animals and yeasts

Kosarek, J. N., Woodruff, R. V., Rivera-Begeman, A., Guo, C., D’Souza, S., Koonin, E. V., Walker, G. C., & Friedberg, E. C. (2008) · DNA repair · doi:10.1016/j.dnarep.2007.11.016 · Cited by 46

Pol η is required for DNA replication during nucleotide deprivation by hydroxyurea

de Feraudy, S. D., Limoli, C., Giedzinski, E., Karentz, D., Marti, T., Feeney, L., & Cleaver, J. (2007) · Oncogene · doi:10.1038/sj.onc.1210385 · Cited by 45

Analysis of ligation and DNA binding by Escherichia coli DNA ligase (LigA)

Wilkinson, A., Smith, A. J. O., Bullard, D. R., Lavesa-Curto, M., Sayer, H., Bonner, A., Hemmings, A. M., & Bowater, R. P. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2005.03.003 · Cited by 44

Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase κ

Bavoux, C., Hoffmann, J., & Cazaux, C. (2005) · Biochimie · doi:10.1016/j.biochi.2005.02.007 · Cited by 43

Novel conserved motifs in Rev1 C-terminus are required for mutagenic DNA damage tolerance

D’Souza, S., Waters, L. S., & Walker, G. C. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.05.009 · Cited by 43

The in Vivo Characterization of Translesion Synthesis Across UV-Induced Lesions in Saccharomyces cerevisiae: Insights Into Polζ- and Polη-Dependent Frameshift Mutagenesis

Abdulovic, A. L., & Jinks-Robertson, S. (2005) · Genetics · doi:10.1534/genetics.105.052480 · Cited by 43

Novel evidences for a tumor suppressor role of Rev3, the catalytic subunit of Pol ζ

Brondello, J., Pillaire, M., Rodriguez, C., Gourraud, P., Sèlves, J., Cazaux, C., & Piette, J. (2008) · Oncogene · doi:10.1038/onc.2008.212 · Cited by 42

Alteration of ultraviolet-induced mutagenesis in yeast through molecular modulation of the REV3 and REV7 gene expression

Rajpal, D. K., Wu, X., & Wang, Z. (2000) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(00)00047-1 · Cited by 41

Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase κ in colorectal cancer

Lemée, F., Bavoux, C., Pillaire, M., Bieth, A., Machado, C. R., Pena, S. D. J., Guimbaud, R., Sèlves, J., Hoffmann, J., & Cazaux, C. (2006) · Oncogene · doi:10.1038/sj.onc.1210116 · Cited by 41

Involvement of Vertebrate Polκ in Translesion DNA Synthesis across DNA Monoalkylation Damage

Takenaka, K., Ogi, T., Okada, T., Sonoda, E., Guo, C., Friedberg, E. C., & Takeda, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506153200 · Cited by 37

The REV3 gene of Saccharomyces cerevisiae is transcriptionally regulated more like a repair gene than one encoding a DNA polymerase

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Human DNA polymerase κ forms nonproductive complexes with matched primer termini but not with mismatched primer termini

Carlson, K. D., Johnson, R. E., Prakash, L., Prakash, S., & Washington, M. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605785103 · Cited by 35

Adenovirus ADP protein (E3-11.6K), which is required for efficient cell lysis and virus release, interacts with human MAD2B

Ying, B., & Wold, W. S. M. (2003) · Virology · doi:10.1016/s0042-6822(03)00287-3 · Cited by 35

hRev7, putative subunit of hPolζ, plays a critical role in survival, induction of mutations, and progression through S-phase, of UV(254nm)-irradiated human fibroblasts

McNally, K. L., Neal, J. A., McManus, T. P., McCormick, J. J., & Maher, V. M. (2008) · DNA repair · doi:10.1016/j.dnarep.2007.12.013 · Cited by 34

The role of DNA polymerase ι in UV mutational spectra

Choi, J., Nia, A. B., Lee, D.-H., Lee, C.-S., & Pfeifer, G. P. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.01.003 · Cited by 33

Proficient and Accurate Bypass of Persistent DNA Lesions by DinB DNA Polymerases

Jarosz, D. F., Godoy, V. G., & Walker, G. C. (2007) · Cell Cycle · doi:10.4161/cc.6.7.4065 · Cited by 32

Differential sensitivity of Fanconi anaemia lymphocytes to the clastogenic action of cis-diamminedichloroplatinum (II) and trans-diamminedichloroplatinum (II)

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Role of Single-stranded DNA in Targeting REV1 to Primer Termini

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Translesion synthesis of acetylaminofluorene-dG adducts by DNA polymerase is stimulated by yeast Rev1 protein

Guo, D. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh279 · Cited by 31

Overproduction of DNA polymerase eta does not raise the spontaneous mutation rate in diploid human fibroblasts

King, N. M., Nikolaishvili‐Feinberg, N., Bryant, M. F., Luche, D. D., Heffernan, T. P., Simpson, D. A., Hanaoka, F., Kaufmann, W. K., & Cordeiro‐Stone, M. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.04.002 · Cited by 30

REV1 accumulates in DNA damage-induced nuclear foci in human cells and is implicated in mutagenesis by benzo[a]pyrenediolepoxide

Mukhopadhyay, S. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh903 · Cited by 30

DNA polymerases η and κ are responsible for error-free translesion DNA synthesis activity over a cis–syn thymine dimer in Xenopus laevis oocyte extracts

Yagi, Y., Ogawara, D., Iwai, S., Hanaoka, F., Akiyama, M., & Maki, H. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.06.010 · Cited by 28

Fidelity and Damage Bypass Ability of Schizosaccharomyces pombe Eso1 Protein, Comprised of DNA Polymerase η and Sister Chromatid Cohesion Protein Ctf7

Madril, A. C., Johnson, R. E., Washington, M. T., Prakash, L., & Prakash, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106917200 · Cited by 28

Characterization of the DNA Binding and Structural Properties of the BRCT Region of Human Replication Factor C p140 Subunit

Kobayashi, M., Figaroa, F., Meeuwenoord, N. J., Jansen, L. E. T., & Siegal, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m511090200 · Cited by 27

Purification of Drosophila DNA polymerase ζ by REV1 protein-affinity chromatography

TAKEUCHI, R., Oshige, M., Uchida, M., Ishikawa, G., Takata, K., Shimanouchi, K., Kanai, Y., Ruike, T., Morioka, H., & Sakaguchi, K. (2004) · Biochemical Journal · doi:10.1042/bj20031833 · Cited by 27

hHR23B is required for genotoxic-specific activation of p53 and apoptosis

Kaur, M., Pop, M. S., Shi, D., Brignone, C., & Grossman, S. R. (2006) · Oncogene · doi:10.1038/sj.onc.1209865 · Cited by 27

Efficiency, Fidelity and Enzymatic Switching DurinG Translesion DNA Synthesis

McCulloch, S. D., Kokoska, R. J., & Kunkel, T. A. (2004) · Cell Cycle · doi:10.4161/cc.3.5.893 · Cited by 27

Xeroderma pigmentosum: beyond skin cancer.

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Examining the potential role of DNA polymerases η and ζ in triplet repeat instability in yeast

Dixon, M. J. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00095-2 · Cited by 26

Analyses of ultraviolet‐induced focus formation of hREV1 protein

Murakumo, Y., Mizutani, S., Yamaguchi, M., Ichihara, M., & Takahashi, M. (2006) · Genes to Cells · doi:10.1111/j.1365-2443.2006.00938.x · Cited by 26

Deoxynucleotide Triphosphate Binding Mode Conserved in Y Family DNA Polymerases

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Rev1 enhances CAG·CTG repeat stability in Saccharomyces cerevisiae

Collins, N. S., Bhattacharyya, S., & Lahue, R. S. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.08.002 · Cited by 23

Dna Repair in Tumor Cells from the Variant form of Xeroderma Pigmentosum

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REV1 genetic variants associated with the risk of cervical carcinoma

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Ubiquitylation of Proliferating Cell Nuclear Antigen and Recruitment of Human DNA Polymerase η

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Mutation Frequencies and Spectra in DNA Polymerase η–Deficient Mice

Busuttil, R. A., Lin, Q., Stambrook, P. J., Kucherlapati, R., & Vijg, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6274 · Cited by 20

Regulation of Saccharomyces cerevisiae DNA polymerase η transcript and protein

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Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2

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Decreased mutagenicity in Fanconi's anemia lymphoblasts following treatment with photoactivated psoralens.

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Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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Targeting the DNA Damage Response in Cancer

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RNA m6A methylation regulates the ultraviolet-induced DNA damage response

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DNA polymerases and cancer

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Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathwayPreprint

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Translesion DNA polymerases in eukaryotes: what makes them tick?

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Eukaryotic mutagenesis and translesion replication dependent on DNA polymerase ζ and Rev I protein

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Filling gaps in translesion DNA synthesis in human cells

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Insights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain

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The Rev1-Polζ translesion synthesis mutasome: Structure, interactions and inhibition

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