Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

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The dinB Gene Encodes a Novel E. coli DNA Polymerase, DNA Pol IV, Involved in Mutagenesis

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Translesion synthesis: Y-family polymerases and the polymerase switch

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Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η

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Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

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The human DINB1 gene encodes the DNA polymerase Polθ

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Fidelity and Processivity of Saccharomyces cerevisiae DNA Polymerase η

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A Human REV7 Homolog That Interacts with the Polymerase ζ Catalytic Subunit hREV3 and the Spindle Assembly Checkpoint Protein hMAD2

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The human REV1 gene codes for a DNA template-dependent dCMP transferase

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The Relative Roles in Vivo of Saccharomyces cerevisiae Pol η, Pol ζ, Rev1 Protein and Pol32 in the Bypass and Mutation Induction of an Abasic Site, T-T (6-4) Photoadduct and T-T cis-syn Cyclobutane Dimer

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Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.

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Quantitative Analysis of Translesion DNA Synthesis across a Benzo[a]pyrene-Guanine Adduct in Mammalian Cells

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Stimulation of DNA Synthesis Activity of Human DNA Polymerase κ by PCNA

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The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G 2 /M phase rather than S phase

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The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light

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Crystal structure of a benzo[ a ]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase

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129-derived Strains of Mice Are Deficient in DNA Polymerase ι and Have Normal Immunoglobulin Hypermutation

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Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells

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A Bacterial Effector Targets Mad2L2, an APC Inhibitor, to Modulate Host Cell Cycling

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Disruption of the Rev3l-encoded catalytic subunit of polymerase ζ in mice results in early embryonic lethality

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Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV‐induced DNA breaks

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Nucleotide excision repair and cancer

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The Saccharomyces cerevisiae RAD6 Group Is Composed of an Error-Prone and Two Error-Free Postreplication Repair Pathways

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Damage repair DNA polymerases Y

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Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro

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Specificity of DNA Lesion Bypass by the Yeast DNA Polymerase η

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Replication of damaged DNA by translesion synthesis in human cells

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MAD2B is an inhibitor of the anaphase-promoting complexPreprint

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Cellular Functions of DNA Polymerase ζ and Rev1 Protein

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Replication past O 6 -Methylguanine by Yeast and Human DNA Polymerase η

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The REV1 gene of Saccharomyces cerevisiae: isolation, sequence, and functional analysis

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Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein DinB

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DNA Polymerase κ Is Specifically Required for Recovery from the Benzo[a]pyrene-Dihydrodiol Epoxide (BPDE)-induced S-phase Checkpoint

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Fidelity of Escherichia coli DNA Polymerase IV

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Inhibition of Cdh1–APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1Preprint

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Investigating the Role of the Little Finger Domain of Y-family DNA Polymerases in Low Fidelity Synthesis and Translesion Replication

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Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis

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Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability

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Ubiquitination of PCNA and the Polymerase Switch in Human Cells

Kannouche, P. L., & Lehmann, A. R. (2004) · Cell Cycle · doi:10.4161/cc.3.8.1074 · Cited by 134

Role of DNA Polymerase η in the UV Mutation Spectrum in Human Cells

Stary, A., Kannouche, P. L., Lehmann, A. R., & Sarasin, A. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211838200 · Cited by 133

The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 Genes Are Required for Tolerating Irreparable, Ultraviolet-Induced DNA Damage

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Translesion Synthesis by Human DNA Polymerase η across Thymine Glycol Lesions

Kusumoto, R., Masutani, C., Iwai, S., & Hanaoka, F. (2002) · Biochemistry · doi:10.1021/bi025549k · Cited by 132

Defining the position of the switches between replicative and bypass DNA polymerases

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Complex Formation with Rev1 Enhances the Proficiency of Saccharomyces cerevisiae DNA Polymerase ζ for Mismatch Extension and for Extension Opposite from DNA Lesions

Acharya, N., Johnson, R. E., Prakash, S., & Prakash, L. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01671-06 · Cited by 128

Regulation of polymerase exchange between Polη and Polδ by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme

Zhuang, Z., Johnson, R. E., Haracska, L., Prakash, L., Prakash, S., & Benkovic, S. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801310105 · Cited by 124

The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins

Zhong, X., Garg, P., Stith, C. M. W., McElhinny, S. A. N., Kissling, G. E., Burgers, P., & Kunkel, T. A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl465 · Cited by 124

Human DNA Polymerase ι Incorporates dCTP Opposite Template G via a G.C+ Hoogsteen Base Pair

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S., & Aggarwal, A. K. (2005) · Structure · doi:10.1016/j.str.2005.08.010 · Cited by 123

Yeast DNA Polymerase η Utilizes an Induced-Fit Mechanism of Nucleotide Incorporation

Washington, M. T., Prakash, L., & Prakash, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00613-4 · Cited by 123

p53 and p21 Regulate Error-Prone DNA Repair to Yield a Lower Mutation Load

Avkin, S., Sevilya, Z., Toube, L., Geacintov, N. E., Chaney, S. G., Oren, M., & Livneh, Z. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.022 · Cited by 122

A Novel Role of DNA Polymerase η in Modulating Cellular Sensitivity to Chemotherapeutic Agents

Chen, Y., Cleaver, J. E., Hanaoka, F., Chang, C., & Chou, K.-M. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0118 · Cited by 122

DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer.

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Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase η during copying of a mouse immunoglobulin κ light chain transgene

Pavlov, Y. I., Rogozin, I. B., Galkin, A. P., Aksenova, A. Y., Hanaoka, F., Rada, C., & Kunkel, T. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152126799 · Cited by 120

Evidence that in Xeroderma Pigmentosum Variant Cells, which Lack DNA Polymerase η, DNA Polymerase ι Causes the Very High Frequency and Unique Spectrum of UV-Induced Mutations

Wang, Y., Woodgate, R., McManus, T. P., Mead, S., McCormick, J. J., & Maher, V. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3073 · Cited by 120

UmuD and RecA Directly Modulate the Mutagenic Potential of the Y Family DNA Polymerase DinB

Godoy, V. G., Jarosz, D. F., Simon, S. M., Abyzov, A. S., Ilyin, V., & Walker, G. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.10.025 · Cited by 118

A Ubiquitin-binding Motif in the Translesion DNA Polymerase Rev1 Mediates Its Essential Functional Interaction with Ubiquitinated Proliferating Cell Nuclear Antigen in Response to DNA Damage

Wood, A., Garg, P., & Burgers, P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702366200 · Cited by 118

REV7, a new gene concerned with UV mutagenesis in yeast

Lawrence, C. W., Das, G., & Christensen, R. B. (1985) · Molecular and General Genetics MGG · doi:10.1007/bf00383316 · Cited by 117

The processivity factor β controls DNA polymerase IV traffic during spontaneous mutagenesis and translesion synthesis in vivo

Lenne‐Samuel, N., Wagner, J. E., Etienne, H., & Fuchs, R. P. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf007 · Cited by 116

The 9-1-1 Checkpoint Clamp Physically Interacts with Polζ and Is Partially Required for Spontaneous Polζ-dependent Mutagenesis in Saccharomyces cerevisiae

Sabbioneda, S., Minesinger, B. K., Giannattasio, M., Plevani, P., Muzi-Falconi, M., & Jinks-Robertson, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507638200 · Cited by 116

Human DNA polymerase iota protects cells against oxidative stress

Lajus, T. B. P., Nakajima, S., Zlatanou, A., Despras, E., Couvé, S., Ishchenko, A. A., Sarasin, A. R., Yasui, A., & Kannouche, P. L. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.210 · Cited by 115

Increased Catalytic Activity and Altered Fidelity of Human DNA Polymerase ι in the Presence of Manganese

Frank, E. G., & Woodgate, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702159200 · Cited by 115

Altered DNA Polymerase ι Expression in Breast Cancer Cells Leads to a Reduction in DNA Replication Fidelity and a Higher Rate of Mutagenesis

Jin, Y., Chen, Z., Liu, Y., Hickey, R. J., & Malkas, L. H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0603 · Cited by 115

Mechanism of DNA Polymerization Catalyzed by Sulfolobus solfataricus P2 DNA Polymerase IV

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Crystal Structure of the Catalytic Core of Human DNA Polymerase Kappa

Uljon, S., Johnson, R. E., Edwards, T. A., Prakash, S., Prakash, L., & Aggarwal, A. K. (2004) · Structure · doi:10.1016/j.str.2004.05.011 · Cited by 114

Multiple Roles of Vertebrate REV Genes in DNA Repair and Recombination

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UV-B Radiation Induces Epithelial Tumors in Mice Lacking DNA Polymerase η and Mesenchymal Tumors in Mice Deficient for DNA Polymerase ι

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Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases

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Inefficient Bypass of an Abasic Site by DNA Polymerase η

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Participation of mouse DNA polymerase ι in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer

Dumstorf, C. A., Clark, A. B., Lin, Q., Kissling, G. E., Yuan, T., Kucherlapati, R., McGregor, W. G., & Kunkel, T. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605247103 · Cited by 109

Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase in Saccharomyces cerevisiae

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A novel function of DNA polymerase ζ regulated by PCNA

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The Roles of REV3 and RAD57 in Double-Strand-Break-Repair-Induced Mutagenesis of Saccharomyces cerevisiae

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Properties and Functions of Escherichia Coli: Pol IV and Pol V

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P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation

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Role of DNA polymerases η, ι and ζ in UV resistance and UV-induced mutagenesis in a human cell line

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REV3 and REV1 Play Major Roles in Recombination-independent Repair of DNA Interstrand Cross-links Mediated by Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA)

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Pol32, a Subunit of Saccharomyces cerevisiae DNA Polymerase δ, Suppresses Genomic Deletions and Is Involved in the Mutagenic Bypass Pathway

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Efficient and Error-Free Replication past a Minor-Groove N2-Guanine Adduct by the Sequential Action of Yeast Rev1 and DNA Polymerase ζ

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Addendum

Kannouche, P. L., de Henestrosa, A. R. F., Coull, B. J., Vidal, A. E., Gray, C., Zicha, D., Woodgate, R., & Lehmann, A. R. (2003) · The EMBO Journal · doi:10.1093/emboj/7595006 · Cited by 98

Enzymatic switching for efficient and accurate translesion DNA replication.

McCulloch, S. D., Kokoska, R., Chilkova, O., Welch, C. M., Johansson, E., Burgers, P., & Kunkel, T. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh777 · Cited by 97

The RAD6 Pathway: Control of DNA Damage Bypass and Mutagenesis by Ubiquitin and SUMO

Ulrich, H. D. (2005) · ChemBioChem · doi:10.1002/cbic.200500139 · Cited by 96

Yeast DNA polymerase zeta (ζ) is essential for error-free replication past thymine glycolPreprint

Johnson, R. E., Yu, S., Prakash, S., & Prakash, L. (2003) · Genes & Development · doi:10.1101/gad.1048303 · Cited by 95

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation

Soria, G., Speroni, J., Podhajcer, O. L., Prives, C., & Gottifredi, V. (2008) · Journal of Cell Science · doi:10.1242/jcs.027730 · Cited by 94

Proliferating Cell Nuclear Antigen Promotes Translesion Synthesis by DNA Polymerase ζ

Garg, P., Stith, C. M. W., Majka, J., & Burgers, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500173200 · Cited by 93

Portraits of a Y‐family DNA polymerase

Yang, W. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.11.047 · Cited by 92

Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.

Bavoux, C., Leopoldino, A. M., Bergoglio, V., Wang, J. O., Ogi, T., Bieth, A., Judde, J., Pena, S. D. J., Poupon, M., Helleday, T., et al. (2005) · PubMed · Cited by 92

Inactivation of Human MAD2B in Nasopharyngeal Carcinoma Cells Leads to Chemosensitization to DNA-Damaging Agents

Cheung, H. W., Chun, A. C. S., Wang, Q., Deng, W., Hu, L., Guan, X., Nicholls, J. M., Ling, M., Wong, Y. C., Tsao, S. W., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3602 · Cited by 91

Evidence for an interaction of the metalloprotease‒disintegrin tumour necrosis factor α convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease‒disintegrin MDC9 with a novel MAD2-related protein, MAD2β

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Proliferating Cell Nuclear Antigen-dependent Coordination of the Biological Functions of Human DNA Polymerase ι

Vidal, A. E., Kannouche, P. L., Podust, V. N., Yang, W., Lehmann, A. R., & Woodgate, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406511200 · Cited by 90

The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly

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DNA mismatch repair and p53 function are major determinants of the rate of development of cisplatin resistance

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Involvement of Mouse Rev3 in Tolerance of Endogenous and Exogenous DNA Damage

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Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase

Yamada, A., Masutani, C., Iwai, S., & Hanaoka, F. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.13.2473 · Cited by 88

Complex Formation of Yeast Rev1 and Rev7 Proteins: a Novel Role for the Polymerase-Associated Domain

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Glycogen Synthase Kinase 3β Phosphorylates p21WAF1/CIP1 for Proteasomal Degradation after UV Irradiation

Lee, J. Y., Yu, S., Park, Y. G., Kim, J., & Sohn, J. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01461-06 · Cited by 87

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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Targeting the DNA Damage Response in Cancer

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RNA m6A methylation regulates the ultraviolet-induced DNA damage response

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DNA polymerases and cancer

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Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathwayPreprint

Kim, H., & D’Andrea, A. D. (2012) · Genes & Development · doi:10.1101/gad.195248.112 · Cited by 534

Translesion DNA polymerases in eukaryotes: what makes them tick?

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Eukaryotic mutagenesis and translesion replication dependent on DNA polymerase ζ and Rev I protein

Lawrence, C. W., & Maher, V. M. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290187 · Cited by 38

Filling gaps in translesion DNA synthesis in human cells

Quinet, A., Lerner, L. K., Martins, D. J., & Menck, C. F. M. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.02.004 · Cited by 46

Insights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain

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The Rev1-Polζ translesion synthesis mutasome: Structure, interactions and inhibition

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