Cited by 616DNA Repair MechanismsFungal and yeast genetics researchBacterial Genetics and Biotechnology

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Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

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Waters, Lauren S., Minesinger, Brenda K., Wiltrout, Mary Ellen, D'Souza, Sanjay, Woodruff, Rachel V., Walker, Graham C.·2009·Microbiology and Molecular Biology Reviews

DOI 10.1128/mmbr.00034-08PMC PMC2650891

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Abstract

SUMMARY: DNA repair and DNA damage tolerance machineries are crucial to overcome the vast array of DNA damage that a cell encounters during its lifetime. In this review, we summarize the current state of knowledge about the eukaryotic DNA damage tolerance pathway translesion synthesis (TLS), a process in which specialized DNA polymerases replicate across from DNA lesions. TLS aids in resistance to DNA damage, presumably by restarting stalled replication forks or filling in gaps that remain in the genome due to the presence of DNA lesions. One consequence of this process is the potential risk of introducing mutations. Given the role of these translesion polymerases in mutagenesis, we discuss the significant regulatory mechanisms that control the five known eukaryotic translesion polymerases: Rev1, Pol ζ, Pol κ, Pol η, and Pol ι.

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Authors: Waters, L. S., Minesinger, B. K., Wiltrout, M. E., D'Souza, S., Woodruff, R. V., & Walker, G. C.
Affiliations: Massachusetts Institute of Technology (US)
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 01239
ORCID: Wiltrout, Mary Ellen
Walker, Graham C.
Venue: Microbiology and Molecular Biology Reviews
Publisher: American Society for Microbiology
Published: 2009-03
Volume: 73
Issue: 1
Pages: 134-154
ISSN: 1092-2172 (ISSN-L)
1098-5557
DOI: 10.1128/mmbr.00034-08
PMC: PMC2650891
OpenAlex: W2167668429
Cited by: 591
References: 286
Citations by year: 2026: 11 · 2025: 17 · 2024: 15 · 2023: 23 · 2022: 34 · 2021: 26 · 2020: 35 · 2019: 33 · 2018: 38 · 2017: 45 · 2016: 36 · 2015: 40 · 2014: 42 · 2013: 48 · 2012: 57
FWCI: 3.65
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Microbiology and Molecular Biology Reviews (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (F32GM078966)
National Institute of Environmental Health Sciences (P30ES002109, R01ES015818)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: translesion synthesis, DNA damage tolerance, DNA repair, Rev1, Pol eta, mutagenesis, replication fork restart
MeSH terms: DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, Eukaryotic Cells, Humans, Models, Molecular, Yeasts

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Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

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