The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The Role of CRISPR-Cas Systems in Virulence of Pathogenic Bacteria
Open accessAbstract
SUMMARY: Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes are present in many bacterial and archaeal genomes. Since the discovery of the typical CRISPR loci in the 1980s, well before their physiological role was revealed, their variable sequences have been used as a complementary typing tool in diagnostic, epidemiologic, and evolutionary analyses of prokaryotic strains. The discovery that CRISPR spacers are often identical to sequence fragments of mobile genetic elements was a major breakthrough that eventually led to the elucidation of CRISPR-Cas as an adaptive immunity system. Key elements of this unique prokaryotic defense system are small CRISPR RNAs that guide nucleases to complementary target nucleic acids of invading viruses and plasmids, generally followed by the degradation of the invader. In addition, several recent studies have pointed at direct links of CRISPR-Cas to regulation of a range of stress-related phenomena. An interesting example concerns a pathogenic bacterium that possesses a CRISPR-associated ribonucleoprotein complex that may play a dual role in defense and/or virulence. In this review, we describe recently reported cases of potential involvement of CRISPR-Cas systems in bacterial stress responses in general and bacterial virulence in particular.
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Cites
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
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CRISPR RNA Maturation by Trans-Encoded Small RNA and Host Factor RNase III
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RNA-guided editing of bacterial genomes using CRISPR-Cas systems
Jiang, W., Bikard, D., Cox, D., Zhang, F., & Marraffini, L. A. (2013) · Nature Biotechnology · doi:10.1038/nbt.2508 · Cited by 2,429
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
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“1 and 4), suggesting that the Salmonella CRISPR-Cas system is involved in infection in vivo (77).”
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Cited by
An updated evolutionary classification of CRISPR–Cas systems
Makarova, K. S., Wolf, Y. I., Alkhnbashi, O. S., Costa, F., Shah, S. A., Saunders, S. J., Barrangou, R., Brouns, S. J. J., Charpentier, E., Haft, D. H., et al. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3569 · Cited by 2,480
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Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence
Moradali, M. F., Ghods, S., & Rehm, B. H. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00039 · Cited by 1,537
A decade of discovery: CRISPR functions and applications
Barrangou, R., & Horvath, P. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.92 · Cited by 319
Kaden, R., Ågren, J., Båverud, V., Hallgren, G., Ferrari, S., Börjesson, J., Lindberg, M., Bäckman, S., & Wahab, T. (2014) · Veterinary Microbiology · doi:10.1016/j.vetmic.2014.10.015 · Cited by 35
Metadata
- Authors
- Louwen, R., Staals, R. H. J., Endtz, H. P., van Baarlen, P., & van der Oost, J.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2014-03
- Volume
- 78
- Issue
- 1
- Pages
- 74-88
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- OpenAlex
- W2059769936
- Cited by
- 247
- References
- 8
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- green
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