The DOI matches its Crossref record; 199 of the 199 references it cites were found in a registry or an index.
Integrons: Past, Present, and Future
Open accessAbstract
SUMMARY: Integrons are versatile gene acquisition systems commonly found in bacterial genomes. They are ancient elements that are a hot spot for genomic complexity, generating phenotypic diversity and shaping adaptive responses. In recent times, they have had a major role in the acquisition, expression, and dissemination of antibiotic resistance genes. Assessing the ongoing threats posed by integrons requires an understanding of their origins and evolutionary history. This review examines the functions and activities of integrons before the antibiotic era. It shows how antibiotic use selected particular integrons from among the environmental pool of these elements, such that integrons carrying resistance genes are now present in the majority of Gram-negative pathogens. Finally, it examines the potential consequences of widespread pollution with the novel integrons that have been assembled via the agency of human antibiotic use and speculates on the potential uses of integrons as platforms for biotechnology.
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Environmental factors influencing the development and spread of antibiotic resistance
Bengtsson-Palme, J., Kristiansson, E., & Larsson, D. G. J. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux053 · Cited by 1,167
Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance
Uruén, C., Chopo-Escuin, G., Tommassen, J., Mainar-Jaime, R. C., & Arenas, J. (2020) · Antibiotics · doi:10.3390/antibiotics10010003 · Cited by 769
Hora, P. I., Pati, S. G., McNamara, P. J., & Arnold, W. A. (2020) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.0c00437 · Cited by 422
Quaternary ammonium disinfectants: microbial adaptation, degradation and ecology
Tezel, U., & Pavlostathis, S. G. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2015.03.018 · Cited by 393
Identification and analysis of integrons and cassette arrays in bacterial genomes
Cury, J., Jové, T., Touchon, M., Néron, B., & Rocha, E. P. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw319 · Cited by 317
Metadata
- Authors
- Gillings, M. R.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2014-06
- Volume
- 78
- Issue
- 2
- Pages
- 257-277
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- OpenAlex
- W1990524884
- Cited by
- 743
- References
- 199
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- green
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