The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Type V Protein Secretion Pathway: the Autotransporter Story
Open accessAbstract
SUMMARY: Gram-negative bacteria possess an outer membrane layer which constrains uptake and secretion of solutes and polypeptides. To overcome this barrier, bacteria have developed several systems for protein secretion. The type V secretion pathway encompasses the autotransporter proteins, the two-partner secretion system, and the recently described type Vc or AT-2 family of proteins. Since its discovery in the late 1980s, this family of secreted proteins has expanded continuously, due largely to the advent of the genomic age, to become the largest group of secreted proteins in gram-negative bacteria. Several of these proteins play essential roles in the pathogenesis of bacterial infections and have been characterized in detail, demonstrating a diverse array of function including the ability to condense host cell actin and to modulate apoptosis. However, most of the autotransporter proteins remain to be characterized. In light of new discoveries and controversies in this research field, this review considers the autotransporter secretion process in the context of the more general field of bacterial protein translocation and exoprotein function.
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Bacterial Adhesion and Entry into Host Cells
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“…leader peptide for secretion across the inner membrane, a C-terminal domain that forms a pore in the outer membrane, and a passenger domain that is autotransported through the outer membrane pore to be exposed on the bacterial surface, for cleavage in certain cases (Henderson et al., 2004).”
Type VII secretion — mycobacteria show the way
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Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv. oryzae PXO99A
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Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue
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Self-citation
Metadata
- Authors
- Henderson, I. R., Navarro-Garcia, F., Desvaux, M., Fernandez, R. C., & Ala'Aldeen, D.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2004-12
- Volume
- 68
- Issue
- 4
- Pages
- 692-744
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- OpenAlex
- W2109951903
- Cited by
- 841
- References
- 10
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- green
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