Viral genes and cellular markers associated with neurological complications during herpesvirus infections

Holz, Carine L.; Nelli, Rahul K.; Wilson, M. Eilidh; Zarski, Lila M.; Azab, Walid; Baumgardner, Rachel; Osterrieder, Nikolaus; Pease, Anthony; Zhang, Liangliang; Hession, Sarah; Goehring, Lutz S.; Hussey, Stephen B.; Soboll Hussey, Gisela

doi:10.1099/jgv.0.000773

Cited by 34Herpesvirus Infections and TreatmentsAnimal Virus Infections Studiesinterferon and immune responses

Viral genes and cellular markers associated with neurological complications during herpesvirus infections

Holz, Carine L., Nelli, Rahul K., Wilson, M. Eilidh, Zarski, Lila M., Azab, Walid, Baumgardner, Rachel, Osterrieder, Nikolaus, Pease, Anthony +5 more·2017·Journal of General Virology

DOI 10.1099/jgv.0.000773

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Abstract

Despite the importance of neurological disorders associated with herpesviruses, the mechanism by which these viruses influence the central nervous system (CNS) has not been definitively established. Owing to the limitations of studying neuropathogenicity of human herpesviruses in their natural host, many aspects of their pathogenicity and immune response are studied in animal models. Here, we present an important model system that enables studying neuropathogenicity of herpesviruses in the natural host. Equine herpesvirus type 1 (EHV-1) is an alphaherpesvirus that causes a devastating neurological disease (EHV-1 myeloencephalopathy; EHM) in horses. Like other alphaherpesviruses, our understanding of virus neuropathogenicity in the natural host beyond the essential role of viraemia is limited. In particular, information on the role of different viral proteins for virus transfer to the spinal cord endothelium in vivo is lacking. In this study, the contribution of two viral proteins, DNA polymerase (ORF30) and glycoprotein D (gD), to the pathogenicity of EHM was addressed. Furthermore, different cellular immune markers, including alpha-interferon (IFN-α), gamma-interferon (IFN-γ), interleukin-10 (IL-10) and interleukin-1 beta (IL-1β), were identified to play a role during the course of the disease.

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EHV-1-infected PBMC have the ability to roll and then adhere to the endothelium to facilitate virus spread, probably after the upregulation of certain adhesion molecules and cytokines.
“We have recently shown that EHV-1-infected PBMC have the ability to roll and then adhere to the endothelium to facilitate virus spread, probably after the upregulation of certain adhesion molecules and cytokines (Holz et al., 2017; Proft et al., 2016; Spiesschaert et al., 2015a).”
From Equid Herpesvirus-1 Exploits the Extracellular Matrix of Mononuclear Cells to Ensure Transport to Target Cells (2020) · cites this paper as Holz et al., 2017

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Authors: Holz, C. L., Nelli, R. K., Wilson, M. E., Zarski, L. M., Azab, W., Baumgardner, R., Osterrieder, N., Pease, A., Zhang, L., Hession, S., Goehring, L. S., Hussey, S. B., & Soboll Hussey, G.
Affiliations: Michigan State University (US)
Freie Universität Berlin (DE)
Ludwig-Maximilians-Universität München (DE)
Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
ORCID: Holz, Carine L.
Nelli, Rahul K.
Azab, Walid
Osterrieder, Nikolaus
Zhang, Liangliang
Goehring, Lutz S.
Venue: Journal of General Virology
Publisher: Microbiology Society
Published: 2017-06-01
Volume: 98
Issue: 6
Pages: 1439-1454
ISSN: 0022-1317 (ISSN-L)
1465-2099
DOI: 10.1099/jgv.0.000773
OpenAlex: W2643405330
Cited by: 34
References: 82
Citations by year: 2025: 1 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 8 · 2018: 3 · 2017: 2
FWCI: 3.43
Type: journal article
Language: en
Open access: closed
Locations: Journal of General Virology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: equine herpesvirus 1, glycoprotein D, interferon-alpha, interferon-gamma, IL-10, IL-1β, horses
MeSH terms: Animals, Herpesvirus 1, Equid, Female, Herpesviridae Infections, Horses, Male, Viral Proteins, Biomarkers, Encephalitis, Viral, Models, Animal, Virulence Factors, Host-Pathogen Interactions

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Viral genes and cellular markers associated with neurological complications during herpesvirus infections

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