Assessment of the In Vitro and In Vivo Antifungal Activity of NSC319726 against Candida auris
Open accessAbstract
Candida auris is emerging as a major public health threat because of its ability to cause nosocomial outbreaks of severe invasive candidiasis. Management of C. auris infection is difficult because of its frequent multidrug-resistant profile for currently licensed antifungals.
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None of these changes were observed in the C. auris I.3 strain, which exhibits echinocandin resistance due to the S639F mutation in β-1,3-glucan synthase FKS1.
“None of these changes were observed in the C. auris I.3 strain, which exhibits echinocandin resistance due to the S639F mutation in β-1,3-glucan synthase FKS176.”
From Distinct echinocandin responses of Candida albicans and Candida auris cell walls revealed by solid-state NMR (2025) · cites this paper as [76]
The Results section identifies C. auris I.3 as an echinocandin-resistant isolate. It does not identify an S639F mutation in FKS1 or establish that mutation as the cause of resistance. The cited paper also does not describe the unspecified 'changes' whose absence the sentence attributes to I.3 (page unavailable). (LLM, conf=0.84)
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Cites
Chowdhary, A., Sharma, C., & Meis, J. F. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006290 · Cited by 750 · see citing works
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Research works printed but not linked: 18
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Cited by
Sorted by citations
Deciphering the Mrr1/Mdr1 Pathway in Azole Resistance of Candida auris
Li, J., Coste, A. T., Bachmann, D., Sanglard, D., & Lamoth, F. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00067-22 · Cited by 59 · see citing works
Self-citationDickwella Widanage, M. C., Singh, K., Li, J., Yarava, J. R., Scott, F. J., Xu, Y., Gow, N. A. R., Mentink-Vigier, F., Wang, P., Lamoth, F., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61678-1 · Cited by 51 · see citing works
Self-citation
- Authors
- Li, J., Coste, A. T., Bachmann, D., Sanglard, D., & Lamoth, F.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2021-12-22
- Volume
- 9
- Issue
- 3
- Pages
- e0139521-e0139521
- ISSN
- 2165-0497 (ISSN-L)
- PMC
- PMC8567239
- OpenAlex
- W3210344257
- Cited by
- 14
- References
- 1
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 1 · 2022: 3
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbiology Spectrum (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, cc-by)
- IRIS (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fondation Santos-Suarez pour la Recherche Médicale
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida auris, antifungal activity, Galleria mellonella, invertebrate infection model, drug tolerance
- MeSH terms
- Micafungin, Candida auris, Amphotericin B, Antifungal Agents, Cross Infection, Drug Interactions, Humans, Microbial Sensitivity Tests, Pyridines, Fluconazole, Candidiasis, Invasive, Candidemia
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