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The PqsE-RhlR Interaction Regulates RhlR DNA Binding to Control Virulence Factor Production in Pseudomonas aeruginosa
Abstract
Bacteria use a cell-cell communication process called quorum sensing (QS) to orchestrate collective behaviors. QS relies on the group-wide detection of molecules called autoinducers (AI).
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“Structural and functional studies show that PqsE enhances RhlR-dependent transcription. This activity can reduce the need for the native Rhl autoinducer and preserve RhlR-driven behavior [64,65,66].”
From Understanding Pseudomonas aeruginosa Biofilms: Quorum Sensing, c-di-GMP Signaling, and Emerging Antibiofilm Approaches (2026) · cites this paper as [64]
In the citing paper
“At the core of the QS network, RhlR partners with PqsE to modify transcriptional programs. Structural work identifies a targetable interface between RhlR and PqsE [64,65,73].”
From Understanding Pseudomonas aeruginosa Biofilms: Quorum Sensing, c-di-GMP Signaling, and Emerging Antibiofilm Approaches (2026) · cites this paper as [64]
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Cited by
(2023) · doi:10.1038/s41467-023-43702-4 · Cited by 55
Small protein modules dictate prophage fates during polylysogeny
Silpe, J. E., Duddy, O. P., Johnson, G. E., Beggs, G. A., Hussain, F. A., Forsberg, K. J., & Bassler, B. L. (2023) · Nature · doi:10.1038/s41586-023-06376-y · Cited by 52
Self-citationElbehiry, A., Marzouk, E., Edrees, H. M., Ibrahem, M., Alzahrani, S., Anagreyyah, S., Abualola, H., Alghamdi, A., Alzahrani, A., Jaber, M., et al. (2026) · Microorganisms · doi:10.3390/microorganisms14010109 · Cited by 34
Metadata
- Authors
- Simanek, K. A., Taylor, I. R., Richael, E. K., Lasek-Nesselquist, E., Bassler, B. L., & Paczkowski, J. E.
- Affiliations
- Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, New York, USA
- Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
- Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, USA
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2022-02-23
- Volume
- 10
- Issue
- 1
- ISSN
- 2165-0497
- Cited by
- 85
- References
- 0
- Language
- en
- Licence
- creativecommons.org/licenses/by/4.0/ (vor)
- journals.asm.org/non-commercial-tdm-license (tdm)
- Funders
- Cystic Fibrosis Foundation
- HHS | NIH | National Institute of General Medical Sciences
- Howard Hughes Medical Institute
- National Science Foundation
- New York Community Trust
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- This page
- CoChat. (2026). Citation check: The PqsE-RhlR Interaction Regulates RhlR DNA Binding to Control Virulence Factor Production in Pseudomonas aeruginosa. https://app.cochat.ai/papers/10.1128/spectrum.02108-21
- The paper
- Simanek, K. A., Taylor, I. R., Richael, E. K., Lasek-Nesselquist, E., Bassler, B. L., & Paczkowski, J. E. (2022). The PqsE-RhlR Interaction Regulates RhlR DNA Binding to Control Virulence Factor Production in Pseudomonas aeruginosa. Microbiology Spectrum. https://doi.org/10.1128/spectrum.02108-21
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.