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Activity of DNA Repair Systems in the Cells of Long-Lived Rodents and Bats

Popov, Aleksei A., Petruseva, Irina O., Lavrik, Olga I.·2024·Biochemistry (Moscow)
DOI 10.1134/s0006297924060038
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Abstract

Damages of various origin accumulated in the genomic DNA can lead to the breach of genome stability, and are considered to be one of the main factors involved in cellular senescence. DNA repair systems in mammalian cells ensure effective damage removal and repair of the genome structure, therefore, activity of these systems is expected to be correlated with high maximum lifespan observed in the long-lived mammals. This review discusses current results of the studies focused on determination of the DNA repair system activity and investigation of the properties of its key regulatory proteins in the cells of long-lived rodents and bats. Based on the works discussed in the review, it could be concluded that the long-lived rodents and bats in general demonstrate high efficiency in functioning and regulation of DNA repair systems. Nevertheless, a number of questions around the study of DNA repair in the cells of long-lived rodents and bats remain poorly understood, answers to which could open up new avenues for further research.

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  • Long-lived animals share enhanced DNA repair, reduced molecular error rates and other processes.

    “Long-lived animals share enhanced DNA repair3,5,9–11, reduced molecular error rates and other processes6,12–14.”

    From A damage accumulation model identifies distinct aging regimes across species (2026) · cites this paper as [9]

  • Reduced production of senescent cells in long-lived mammals can be due to enhanced repair of cellular damage, such as double-stranded breaks.

    “Reduced production of senescent cells in long-lived mammals can be due to enhanced repair of cellular damage, such as double-stranded breaks3,9–11,58.”

    From A damage accumulation model identifies distinct aging regimes across species (2026) · cites this paper as [9]

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Metadata

Authors
Popov, A. A., Petruseva, I. O., & Lavrik, O. I.
Venue
Biochemistry (Moscow)
Publisher
Pleiades Publishing Ltd
Published
2024-06
Volume
89
Issue
6
Pages
1014-1023
ISSN
  • 0006-2979
  • 1608-3040
DOI
10.1134/s0006297924060038
Cited by
6
References
9
Language
en
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