CoChat
Sign Up
Cited by 72

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

Simon, Matthew, Yang, Jiping, Gigas, Jonathan, Earley, Eric J, Hillpot, Eric, Zhang, Lei, Zagorulya, Maria, Tombline, Greg, Gilbert, Michael, Yuen, Samantha L, Pope, Alexis, Van Meter, Michael, Emmrich, Stephan, Firsanov, Denis, Athreya, Advait, Biashad, Seyed Ali, Han, Jeehae, Ryu, Seungjin, Tare, Archana, Zhu, Yizhou, Hudgins, Adam, Atzmon, Gil, Barzilai, Nir, Wolfe, Aaron, Moody, Kelsey, Garcia, Benjamin A, Thomas, David D, Robbins, Paul D, Vijg, Jan, Seluanov, Andrei, Suh, Yousin, Gorbunova, Vera·2022·The EMBO Journal
DOI 10.15252/embj.2021110393PMC PMC9627671

Published version of a preprint

Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.15252/embj.2021110393

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 9 references

Research works printed but not linked: 61

  1. Adolph KW (1987) ADPribosylation of nuclear proteins labeled with [3H]adenosine: changes during the HeLa cycle. Biochim Biophys Acta 909: 222–230 · DOI
  2. Adolph KW, Song MK (1985) Variations in ADP‐ribosylation of nuclear scaffold proteins during the HeLa cell cycle. Biochem Biophys Res Commun 126: 840–847 · DOI
  3. Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, Lipton R, Cheng S, Shuldiner AR (2003) Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA 290: 2030–2040 · DOI
  4. Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C (2012) Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. Mol Cell 46: 212–225 · DOI
  5. Bilan V, Leutert M, Nanni P, Panse C, Hottiger MO (2017) Combining higher‐energy collision dissociation and electron‐transfer/higher‐energy collision dissociation fragmentation in a product‐dependent manner confidently assigns proteomewide ADP‐ribose acceptor sites. Anal Chem 89: 1523–1530 · DOI
  6. Bonfiglio JJ, Leidecker O, Dauben H, Longarini EJ, Colby T, San Segundo‐Acosta P, Perez KA, Matic I (2020) An HPF1/PARP1‐based chemical biology strategy for exploring ADP‐ribosylation. Cell 183: 1086–1102 · DOI
  7. Broer L, Buchman AS, Deelen J, Evans DS, Faul JD, Lunetta KL, Sebastiani P, Smith JA, Smith AV, Tanaka T et al (2015) GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol A Biol Sci Med Sci 70: 110–118 · DOI
  8. Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G et al (2012) Human longevity and common variations in the LMNA gene: a meta‐analysis. Aging Cell 11: 475–481 · DOI
  9. De Sandre‐Giovannoli A, Bernard R, Cau P, Navarro C, Amiel J, Boccaccio I, Lyonnet S, Stewart CL, Munnich A, Le Merrer M et al (2003) Lamin a truncation in Hutchinson‐Gilford progeria. Science 300: 2055 · DOI · Paper page
  10. Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N et al (2011) Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell 10: 686–698 · DOI
  11. Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P et al (2003) Recurrent de novo point mutations in lamin A cause Hutchinson‐Gilford progeria syndrome. Nature 423: 293–298 · DOI · Paper page
  12. Etchegaray JP, Mostoslavsky R (2015) Cell Fate by SIRT6 and TETs. Cell Cycle 14: 2187–2188 · DOI
  13. Ferrer CM, Alders M, Postma AV, Park S, Klein MA, Cetinbas M, Pajkrt E, Glas A, van Koningsbruggen S, Christoffels VM et al (2018) An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality. Genes Dev 32: 373–388 · DOI
  14. Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z (2015) Lamin A is an endogenous SIRT6 activator and promotes SIRT6‐mediated DNA repair. Cell Rep 13: 1396–1406 · DOI
  15. Gioutlakis A, Klapa MI, Moschonas NK (2017) PICKLE 2.0: a human protein‐protein interaction meta‐database employing data integration via genetic information ontology. PLoS One 12: e0186039 · DOI
  16. Haince JF, McDonald D, Rodrigue A, Dery U, Masson JY, Hendzel MJ, Poirier GG (2008) PARP1‐dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J Biol Chem 283: 1197–1208 · DOI
  17. Hendriks IA, Larsen SC, Nielsen ML (2019) An advanced strategy for comprehensive profiling of ADP‐ribosylation sites using mass spectrometry‐based proteomics. Mol Cell Proteomics 18: 1010–1026 · DOI
  18. Hirvonen K, Laivuori H, Lahti J, Strandberg T, Eriksson JG, Hackman P (2017) SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men. BMC Med Genet 18: 41 · DOI
  19. Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML (2013) Proteome‐wide identification of poly(ADP‐Ribosyl)ation targets in different genotoxic stress responses. Mol Cell 52: 272–285 · DOI
  20. Kaidi A, Weinert BT, Choudhary C, Jackson SP (2010) Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329: 1348–1353 · DOI · Paper page
  21. Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY et al (2009) SIRT6 links histone H3 lysine 9 deacetylation to NF‐kappaB‐dependent gene expression and organismal life span. Cell 136: 62–74 · DOI · Paper page
  22. Kawahara TL, Rapicavoli NA, Wu AR, Qu K, Quake SR, Chang HY (2011) Dynamic chromatin localization of Sirt6 shapes stress‐ and aging‐related transcriptional networks. PLoS Genet 7: e1002153 · DOI
  23. Lattanzi G, Ortolani M, Columbaro M, Prencipe S, Mattioli E, Lanzarini C, Maraldi NM, Cenni V, Garagnani P, Salvioli S et al (2014) Lamins are rapamycin targets that impact human longevity: a study in centenarians. J Cell Sci 127: 147–157
  24. Leslie Pedrioli DM, Leutert M, Bilan V, Nowak K, Gunasekera K, Ferrari E, Imhof R, Malmstrom L, Hottiger MO (2018) Comprehensive ADP‐ribosylome analysis identifies tyrosine as an ADP‐ribose acceptor site. EMBO Rep 19: e45310 · DOI
  25. Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V et al (2017) A conserved NAD(+) binding pocket that regulates protein‐protein interactions during aging. Science 355: 1312–1317 · DOI
  26. Li Y, Qin J, Wei X, Liang G, Shi L, Jiang M, Xia T, Liang X, He M, Zhang Z (2016) Association of SIRT6 gene polymorphisms with human longevity. Iran J Public Health 45: 1420–1426
  27. Mao Z, Bozzella M, Seluanov A, Gorbunova V (2008) Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst) 7: 1765–1771 · DOI
  28. Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V (2011) SIRT6 promotes DNA repair under stress by activating PARP1. Science 332: 1443–1446 · DOI · Paper page
  29. Martello R, Leutert M, Jungmichel S, Bilan V, Larsen SC, Young C, Hottiger MO, Nielsen ML (2016) Proteome‐wide identification of the endogenous ADP‐ribosylome of mammalian cells and tissue. Nat Commun 7: 12917 · DOI
  30. Min L, Ji Y, Bakiri L, Qiu Z, Cen J, Chen X, Chen L, Scheuch H, Zheng H, Qin L et al (2012) Liver cancer initiation is controlled by AP‐1 through SIRT6‐dependent inhibition of survivin. Nat Cell Biol 14: 1203–1211 · DOI
  31. Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM et al (2006) Genomic instability and aging‐like phenotype in the absence of mammalian SIRT6. Cell 124: 315–329 · DOI · Paper page
  32. Naro C, Bielli P, Pagliarini V, Sette C (2015) The interplay between DNA damage response and RNA processing: the unexpected role of splicing factors as gatekeepers of genome stability. Front Genet 6: 142 · DOI
  33. Nelson MR, Wegmann D, Ehm MG, Kessner D, St Jean P, Verzilli C, Shen J, Tang Z, Bacanu SA, Fraser D et al (2012) An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science 337: 100–104 · DOI · Paper page
  34. Oughtred R, Stark C, Breitkreutz BJ, Rust J, Boucher L, Chang C, Kolas N, O'Donnell L, Leung G, McAdam R et al (2019) The BioGRID interaction database: 2019 update. Nucleic Acids Res 47: D529–D541 · DOI
  35. Pan CP, Muino PL, Barkley MD, Callis PR (2011) Correlation of tryptophan fluorescence spectral shifts and lifetimes arising directly from heterogeneous environment. J Phys Chem B 115: 3245–3253 · DOI
  36. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W et al (2016) SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res 26: 190–205 · DOI
  37. Patil A, Nakamura H (2005) HINT: a database of annotated protein‐protein interactions and their homologs. Biophysics (Nagoya‐shi) 1: 21–24 · DOI
  38. Peric‐Hupkes D, Meuleman W, Pagie L, Bruggeman SW, Solovei I, Brugman W, Graf S, Flicek P, Kerkhoven RM, van Lohuizen M et al (2010) Molecular maps of the reorganization of genome‐nuclear lamina interactions during differentiation. Mol Cell 38: 603–613 · DOI · Paper page
  39. Rahnasto‐Rilla M, Tyni J, Huovinen M, Jarho E, Kulikowicz T, Ravichandran S, A Bohr V, Ferrucci L, Lahtela‐Kakkonen M, Moaddel R (2018) Natural polyphenols as sirtuin 6 modulators. Sci Rep 8: 4163 · DOI
  40. Rajman L, Chwalek K, Sinclair DA (2018) Therapeutic potential of NAD‐boosting molecules: the in vivo evidence. Cell Metab 27: 529–547 · DOI · Paper page
  41. Rezazadeh S, Yang D, Biashad SA, Firsanov D, Takasugi M, Gilbert M, Tombline G, Bhanu NV, Garcia BA, Seluanov A et al (2020) SIRT6 mono‐ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair. Aging (Albany NY) 12: 11165–11184 · DOI
  42. Rezazadeh S, Yang D, Tombline G, Simon M, Regan SP, Seluanov A, Gorbunova V (2019) SIRT6 promotes transcription of a subset of NRF2 targets by mono‐ADP‐ribosylating BAF170. Nucleic Acids Res 47: 7914–7928 · DOI
  43. Roichman A, Elhanati S, Aon MA, Abramovich I, Di Francesco A, Shahar Y, Avivi MY, Shurgi M, Rubinstein A, Wiesner Y et al (2021) Restoration of energy homeostasis by SIRT6 extends healthy lifespan. Nat Commun 12: 3208 · DOI · Paper page
  44. Roichman A, Kanfi Y, Glazz R, Naiman S, Amit U, Landa N, Tinman S, Stein I, Pikarsky E, Leor J et al (2017) SIRT6 overexpression improves various aspects of mouse healthspan. J Gerontol A Biol Sci Med Sci 72: 603–615
  45. Ryu S, Han J, Norden‐Krichmar TM, Schork NJ, Suh Y (2018) Effective discovery of rare variants by pooled target capture sequencing: a comparative analysis with individually indexed target capture sequencing. Mutat Res 809: 24–31
  46. Schuster S, Roessler C, Meleshin M, Zimmermann P, Simic Z, Kambach C, Schiene‐Fischer C, Steegborn C, Hottiger MO, Schutkowski M (2016) A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions. Sci Rep 6: 22643 · DOI
  47. Seluanov A, Mao Z, Gorbunova V (2010) Analysis of DNA double‐strand break (DSB) repair in mammalian cells. J Vis Exp 43: 2002
  48. Shechter D, Dormann HL, Allis CD, Hake SB (2007) Extraction, purification and analysis of histones. Nat Protoc 2: 1445–1457 · DOI
  49. Sidoli S, Bhanu NV, Karch KR, Wang X, Garcia BA (2016) Complete workflow for analysis of histone post‐translational modifications using bottom‐up mass spectrometry: from histone extraction to data analysis. J Vis Exp 111: 54112
  50. Sidoli S, Kori Y, Lopes M, Yuan ZF, Kim HJ, Kulej K, Janssen KA, Agosto LM, Cunha J, Andrews AJ et al (2019) One minute analysis of 200 histone posttranslational modifications by direct injection mass spectrometry. Genome Res 29: 978–987 · DOI
  51. Sidoli S, Lin S, Xiong L, Bhanu NV, Karch KR, Johansen E, Hunter C, Mollah S, Garcia BA (2015) Sequential window acquisition of all theoretical mass spectra (SWATH) analysis for characterization and quantification of histone post‐translational modifications. Mol Cell Proteomics 14: 2420–2428 · DOI
  52. Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL et al (2019) LINE1 derepression in aged wild‐type and SIRT6‐deficient mice drives inflammation. Cell Metab 29: 871–885 · DOI · Paper page
  53. Tasselli L, Xi Y, Zheng W, Tennen RI, Odrowaz Z, Simeoni F, Li W, Chua KF (2016) SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence. Nat Struct Mol Biol 23: 434–440 · DOI
  54. TenNapel MJ, Lynch CF, Burns TL, Wallace R, Smith BJ, Button A, Domann FE (2014) SIRT6 minor allele genotype is associated with >5‐year decrease in lifespan in an aged cohort. PLoS One 9: e115616 · DOI
  55. Van Meter M, Mao Z, Gorbunova V, Seluanov A (2011) SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle 10: 3153–3158 · DOI
  56. Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA et al (2016) JNK phosphorylates SIRT6 to stimulate DNA double‐strand break repair in response to oxidative stress by recruiting PARP1 to DNA breaks. Cell Rep 16: 2641–2650 · DOI
  57. Vivelo CA, Wat R, Agrawal C, Tee HY, Leung AK (2017) ADPriboDB: the database of ADP‐ribosylated proteins. Nucleic Acids Res 45: D204–D209 · DOI
  58. Vohhodina J, Barros EM, Savage AL, Liberante FG, Manti L, Bankhead P, Cosgrove N, Madden AF, Harkin DP, Savage KI (2017) The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export. Nucleic Acids Res 45: 12816–12833 · DOI
  59. Wisniewski JR (2017) Label‐free and standard‐free absolute quantitative proteomics using the “total protein” and “proteomic ruler” approaches. Methods Enzymol 585: 49–60 · DOI
  60. Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z et al (2018) SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature 560: 661–665 · DOI
  61. Zullo JM, Demarco IA, Pique‐Regi R, Gaffney DJ, Epstein CB, Spooner CJ, Luperchio TR, Bernstein BE, Pritchard JK, Reddy KL et al (2012) DNA sequence‐dependent compartmentalization and silencing of chromatin at the nuclear lamina. Cell 149: 1474–1487 · DOI

Cited by

Sorted by citations

See all 72

Metadata

Authors
Simon, M., Yang, J., Gigas, J., Earley, E. J., Hillpot, E., Zhang, L., Zagorulya, M., Tombline, G., Gilbert, M., Yuen, S. L., Pope, A., Van Meter, M., Emmrich, S., Firsanov, D., Athreya, A., Biashad, S. A., Han, J., Ryu, S., Tare, A., Zhu, Y., Hudgins, A., Atzmon, G., Barzilai, N., Wolfe, A., Moody, K., Garcia, B. A., Thomas, D. D., Robbins, P. D., Vijg, J., Seluanov, A., Suh, Y., & Gorbunova, V.
ORCID
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2022-10-10
Volume
41
Issue
21
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.15252/embj.2021110393
PMC
PMC9627671
Cited by
72
References
9
Language
en
Update notices
Licence
Funders
HHS ¦ National Institutes of Health (AG056278, AG027237, AG064706, AG064704, AG046320, AG047200, AG051449, AG057433, AG061521, AG055501, AG057341, AG057706, AG057909, AG17242)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review