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Cited by 129Attention Deficit Hyperactivity DisorderGrowth Hormone and Insulin-like Growth FactorsPharmaceutical studies and practices

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Growth on stimulant medication; clarifying the confusion: a review

Open access
Poulton, A·2005·Archives of Disease in Childhood
DOI 10.1136/adc.2004.056952PMC PMC1720538
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Abstract

AIMS: To get an overview of the studies of growth in height in children with attention deficit hyperactivity disorder (ADHD) treated with stimulant medication, to establish the consistencies and to try to resolve the discrepancies. METHODS: Twenty nine studies were reviewed following a Medline search: 22 related to children, six to late adolescents or adults, and one to children and adults. RESULTS: Children: Eleven studies gave results consistent with height attenuation on stimulant medication: eight were longitudinal, one was cross-sectional, and two showed growth rebound on ceasing medication. Studies with negative findings were inadequately powered (n = 3), lacked controls or statistical analysis (n = 3), measured height velocity without reference to treatment duration (n = 2), or used inappropriate growth parameters (n = 1), controls (n = 1), or normative data (n = 1). Late adolescents/adults treated with stimulant medication in childhood: Two studies associated childhood gastrointestinal side effects with attenuated late adolescent or adult height; all six cross-sectional studies had negative findings. The methodologies varied widely but there was some consistency in the degree of attenuation shown in studies with positive findings. The most sensitive methods analysed the changes in z-scores (standard deviation scores) or calculated the height deficits from paired measurements taken before and after an initial period of treatment with stimulant medication. The height deficit amounted to approximately 1 cm/year during the first 1-3 years of treatment. CONCLUSIONS: Further research is needed into the causal mechanisms, the rate of physical maturation, and the long term implications for final stature.

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Metadata

Authors
Poulton, A.
Affiliations
The University of Sydney (AU)
Corresponding author
Poulton, A
ORCID
Poulton, A
Venue
Archives of Disease in Childhood
Publisher
BMJ
Published
2005-08-01
Volume
90
Issue
8
Pages
801-806
ISSN
  • 0003-9888 (ISSN-L)
  • 1468-2044
DOI
10.1136/adc.2004.056952
PMC
PMC1720538
OpenAlex
W2154426538
Cited by
129
References
42
Citations by year
2025: 5 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 11 · 2014: 9 · 2013: 6 · 2012: 10
FWCI
4.93
Type
journal article
Language
en
Open access
Locations
  • Archives of Disease in Childhood (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords
attention deficit hyperactivity disorder, stimulant medication, height growth, gastrointestinal adverse effects, children, adolescents, adults, height velocity
MeSH terms
Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Body Height, Child, Child, Preschool, Cross-Sectional Studies, Depression, Chemical, Female, Growth Disorders, Humans, Infant, Longitudinal Studies, Male

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