Growth rebound after termination of stimulant drugs

Safer, Daniel J.; Allen, Richard P.; Barr, Evelyn

doi:10.1016/s0022-3476(75)80720-7

Cited by 123Attention Deficit Hyperactivity DisorderPharmacology and Obesity TreatmentPharmaceutical studies and practices

Growth rebound after termination of stimulant drugs

Safer, Daniel J., Allen, Richard P., Barr, Evelyn·1975·The Journal of Pediatrics

DOI 10.1016/s0022-3476(75)80720-7

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Abstract

To explore further the report of an accelerated weight gain following termination of treatment with a stimulant drug, 66 biannual growth measurements were obtained from 1970 to 1973 on hyperactive schoolchildren who were receiving medication. All received either dextroamphetamine or methylphenidate during the school year; some also received it during the summer. The data revealed that those whose stimulant medication was terminated at the start of summer subsequently grew in weight and height at a significantly greater rate than those who continued to receive medication from June to September. In fact, discontinuance of the medication resulted in a growth rebound for this period which was 15-68% above the age-expected increment.

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The use of summer or periodic holidays has been proposed as a strategy to mitigate stimulant-related reductions in growth rates.
“the use of summer (or periodic) holidays, which represent relatively long intervals of nontreatment interspersed within blocks of medication use in clinical practice, has been proposed as a strategy to mitigate stimulant-related reductions in growth rates (Safer et al., 1975)”
From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Safer et al., 1975

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Authors: Safer, D. J., Allen, R. P., & Barr, E.
Affiliations: Johns Hopkins University (US)
Corresponding author: Safer, Daniel J.
ORCID: Safer, Daniel J.
Allen, Richard P.
Venue: The Journal of Pediatrics
Publisher: Elsevier BV
Published: 1975-01
Volume: 86
Issue: 1
Pages: 113-116
ISSN: 0022-3476 (ISSN-L)
DOI: 10.1016/s0022-3476(75)80720-7
OpenAlex: W2040914596
Cited by: 123
References: 6
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 3 · 2019: 1 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 6
FWCI: 10.44
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Journal of Pediatrics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords: d-amphetamine, methylphenidate, hyperactive children, weight gain, height growth, ADHD medication
MeSH terms: Adolescent, Body Height, Body Weight, Child, Dextroamphetamine, Female, Humans, Hyperkinesis, Male, Methylphenidate

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Growth rebound after termination of stimulant drugs

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