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Cited by 99Attention Deficit Hyperactivity DisorderPharmaceutical studies and practicesSchizophrenia research and treatment

Predictors of adult height and weight in boys treated with methylphenidate for childhood behavior problems

KRAMER, JOHN R., LONEY, JAN, PONTO, LAURA BOLES, ANN ROBERTS, MARY, GROSSMAN, STEVEN·2000·Journal of the American Academy of Child & Adolescent Psychiatry
DOI 10.1097/00004583-200004000-00022
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Abstract

Objective To examine associations between childhood treatment with methylphenidate (MPH) and adult height and weight.Method Subjects were 97 boys, aged 4 to 12 years, with behavior problems who were (1) referred to a child psychiatry outpatient clinic, (2) treated clinically with MPH for an average of 36 months, and (3) reevaluated between ages 21 and 23 years. Hierarchical analyses predicted adult height and weight from sets of non-medication and medication-related variables.Results Medicated subjects' age, height, and parental socioeconomic status (SES) at referral predicted 44.8% of variation in adult height. Medicated subjects' birth weight, age, height and weight at referral, and parental SES predicted 61.8% of variation in adult weight. With these non-medication variables held constant, initial nausea and vomiting side effects predicted 4.4% incremental variation in adult height, and MPH maintenance dose predicted 3.2% incremental variation in adult weight.Conclusions Medicated individuals who had attained their final stature did not differ in average height or weight from family, community, or unmedicated controls. Most aspects of medication were not associated with adult height or weight. In some individuals, nausea and vomiting side effects and treatment with higher doses of MPH were associated with adult growth decrements.

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Crossref · 10.1097/00004583-200004000-00022

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  • Kramer et al. (2000) found no differences in self-reported height or weight between the Loney et al. sample followed into adulthood and control groups.

    “Kramer et al. (2000) followed the Loney et al. (1981) sample into adulthood and compared height and weight to control groups drawn from family members (unmedicated brothers and fathers), the community (randomly selected classmates), and clinical groups (individuals with clinical problems but never medicated).No differences in self-reported height or weight were documented.”

    From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Kramer et al. (2000)

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Authors
KRAMER, J. R., LONEY, J., PONTO, L. B., ANN ROBERTS, M., & GROSSMAN, S.
Affiliations
University of Iowa (US)
Corresponding author
KRAMER, JOHN R.
ORCID
KRAMER, JOHN R.
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
2000-04
Volume
39
Issue
4
Pages
517-524
ISSN
0890-8567 (ISSN-L)
DOI
10.1097/00004583-200004000-00022
OpenAlex
W2036610559
Cited by
99
References
27
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 3 · 2015: 5 · 2014: 2 · 2012: 7
FWCI
3.23
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
NIMH (MH-22659 and MH-30735)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
methylphenidate, adult height, mature weight, child behavior problems, attention deficit hyperactivity disorder, growth outcomes, adverse drug reactions, nausea and vomiting, maintenance dose, parental socioeconomic status, birth weight, boys
MeSH terms
Adult, Central Nervous System Stimulants, Body Height, Body Weight, Child, Child Behavior Disorders, Child Development, Child, Preschool, Dose-Response Relationship, Drug, Follow-Up Studies, Humans, Male, Methylphenidate, Nausea, Prospective Studies, Regression Analysis, Vomiting, Confounding Factors, Epidemiologic

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