Growth restriction and gender influence cerebral oxygenation in preterm neonates
Open accessAbstract
OBJECTIVE: To investigate the effect of fetal growth restriction and gender on cerebral oxygenation in preterm neonates during the first 3 days of life. DESIGN: Case-control study. SETTING: Neonatal Intensive Care Unit of the Wilhelmina Children's Hospital, The Netherlands. PATIENTS: 68 (41 males) small for gestational age (SGA) (birth weight <10th percentile) and 136 (82 males) appropriate for gestational age (AGA) (birth weight 20th-80th percentile) neonates, matched for gender, gestational age, ventilatory and blood pressure support. METHODS: Regional cerebral oxygen saturation (rScO2) and cerebral fractional tissue oxygen extraction (cFTOE) as measured by near-infrared spectroscopy throughout the first 72 h of life were compared between SGA and AGA neonates. The effect of gender was also explored within these comparisons. RESULTS: SGA neonates demonstrated higher rScO2 (71% SEM 0.2 vs 68% SEM 0.2) and lower cFTOE (0.25 SEM 0.002 vs 0.29 SEM 0.002) than AGA neonates. There was an independent effect of gender on rScO2 and cFTOE, resulting in the finding that SGA males displayed highest rScO2 and lowest cFTOE (73% SEM 0.3 respectively 0.24 SEM 0.003). AGA males and SGA females showed comparable rScO2 (69% SEM 0.2 vs 69% SEM 0.4) and cFTOE (0.28 SEM 0.002 vs 0.28 SEM 0.004). AGA females showed lowest rScO2 and highest cFTOE (66% SEM 0.2 respectively 0.30 SEM 0.002). CONCLUSIONS: Growth restriction and gender influence cerebral oxygenation and oxygen extraction in preterm neonates throughout the first 3 days of life.
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Average ScO2 values range between approximately 65 and 70% in both term and preterm neonates, in comparison to 46-57% in patients with cyanotic congenital heart disease.
“Average ScO2 values range between approximately 65 and 70% in both term and preterm neonates [68,69], in comparison to 46–57% in patients with cyanotic congenital heart disease [12].”
From Trends and Challenges in Noninvasive Hemodynamic Monitoring of Neonates Following Cardiac Surgery: A Narrative Review (2025) · cites this paper as [69]
Cites
Cohen, J. (1992) · Psychological Bulletin · doi:10.1037//0033-2909.112.1.155 · Cited by 8,771 · see citing works
Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry
Cosgrove, K. P., Mazure, C. M., & Staley, J. K. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.001 · Cited by 996 · see citing works
Standard deviations and standard errors
Altman, D. G., & Bland, M. (2005) · BMJ · doi:10.1136/bmj.331.7521.903 · Cited by 897 · see citing works
The Task Force on Neonatal Encephalopathy (2014) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000445580.65983.d2 · Cited by 519 · see citing works
Relationship of cerebral intraventricular hemorrhage and early childhood neurologic handicaps
Papile, L. A., Munsick-Bruno, G., & Schaefer, A. (1983) · The Journal of Pediatrics · doi:10.1016/s0022-3476(83)80366-7 · Cited by 509 · see citing works
Arduini, D., & Rizzo, G. (1990) · Journal of Perinatal Medicine · doi:10.1515/jpme.1990.18.3.165 · Cited by 480 · see citing works
Monitoring Neonatal Regional Cerebral Oxygen Saturation in Clinical Practice: Value and Pitfalls
van Bel, F., Lemmers, P. M. A., & Naulaers, G. (2008) · Neonatology · doi:10.1159/000151642 · Cited by 259 · see citing works
Self-citationAlderliesten, T., Lemmers, P. M. A., Smarius, J. J. M., et al. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.09.038 · Cited by 254 · see citing works
Self-citationLemmers, P. M. A., Toet, M. C., & van Bel, F. (2007) · PEDIATRICS · doi:10.1542/peds.2007-0925 · Cited by 245 · see citing works
Self-citationNoori, S., McCoy, M., Anderson, M. P., et al. (2013) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2013.09.045 · Cited by 202 · see citing works
Hypotension in Preterm Neonates: Low Blood Pressure Alone Does Not Affect Neurodevelopmental Outcome
Alderliesten, T., Lemmers, P. M. A., van Haastert, I. C., et al. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2013.12.042 · Cited by 153 · see citing works
Self-citationHypoxic regulation of the fetal cerebral circulation
Pearce, W. J. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00990.2005 · Cited by 123 · see citing works
Cardiac Hypertrophy and Altered Hemodynamic Adaptation in Growth-Restricted Preterm Infants
Leipälä, J., Boldt, T., Turpeinen, U., et al. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000061564.86797.78 · Cited by 84 · see citing works
Neonatal cardiac dysfunction in intrauterine growth restriction
Fouzas, S., Karatza, A., Davlouros, P. A., Chrysis, D., Alexopoulos, D., Mantagos, S. P., & Dimitriou, G. (2014) · Pediatric Research · doi:10.1038/pr.2014.22 · Cited by 83 · see citing works
Antenatal assessment of the growth restricted fetus
Baschat, A., & Harman, C. R. (2001) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/00001703-200104000-00011 · Cited by 81 · see citing works
Cerebral Oxygenation Is Depressed During Sleep in Healthy Term Infants When They Sleep Prone
Wong, F. Y., Witcombe, N. B., Yiallourou, S. R., Yorkston, S., Dymowski, A. R., Krishnan, L., WALKER, A. M., & Horne, R. S. C. (2011) · PEDIATRICS · doi:10.1542/peds.2010-2724 · Cited by 79 · see citing works
Rakza, T., Magnenant, E., Klosowski, S., et al. (2007) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.04.058 · Cited by 69 · see citing works
The Effect of Hematocrit and Systolic Blood Pressure on Cerebral Blood Flow in Newborn Infants
Younkin, D. P., Reivich, M., Jaggi, J. L., et al. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.66 · Cited by 69 · see citing works
Baenziger, O., Jaggi, J. L., Mueller, A. C., Morales, C. G., Lipp, H., Lipp, A. E., Duc, G. V., & Bucher, H.-U. (1994) · Pediatric Neurology · doi:10.1016/0887-8994(94)90009-4 · Cited by 68 · see citing works
Cerebrovascular adaptations to chronic hypoxia in the growth restricted lamb
Castillo-Meléndez, M., Yawno, T., Allison, B. J., Jenkin, G., Wallace, E. M., & Miller, S. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.01.004 · Cited by 61 · see citing works
Longo, L. D., & Pearce, W. J. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00462.2004 · Cited by 56 · see citing works
Altın, H., Karaarslan, S., Karataş, Z., Alp, H., Şap, F., & Baysal, T. (2012) · Early Human Development · doi:10.1016/j.earlhumdev.2012.04.003 · Cited by 52 · see citing works
Cardiac adaptation in small for gestational age neonates after prenatal hemodynamic disturbances
Robel‐Tillig, E., Knüpfer, M. M., & Vogtmann, C. (2003) · Early Human Development · doi:10.1016/s0378-3782(03)00045-8 · Cited by 38 · see citing works
Ishii, H., Takami, T., Fujioka, T., Mizukaki, N., Kondo, A., Sunohara, D., Hoshika, A., Akutagawa, O., & Isaka, K. (2013) · Brain and Development · doi:10.1016/j.braindev.2013.06.006 · Cited by 34 · see citing works
Krediet, T. G., Valk, L., Hempenius, I., et al. (2002) · Neonatology · doi:10.1159/000063609 · Cited by 28 · see citing works
Decreased cerebrovascular resistance in small for gestational age infants
van Bel, F., van de Bor, M., Stijnen, T., et al. (1986) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(86)90141-3 · Cited by 24 · see citing works
Ergenekon, E., Hirfanoğlu, İ. M., Turan, Ö., et al. (2011) · Acta Paediatrica · doi:10.1111/j.1651-2227.2011.02358.x · Cited by 21 · see citing works
Guajardo, C. D., Mandelbaum, V. H., & Linderkamp, O. (1994) · Early Human Development · doi:10.1016/0378-3782(94)90078-7 · Cited by 14 · see citing works
Dix, L. M. L., Blok, C. A., Lemmers, P. M. A., et al. (2013) · Neonatology · doi:10.1159/000356167 · Cited by 11 · see citing works
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Weber, F., & Scoones, G. P. (2019) · Pediatric Anesthesia · doi:10.1111/pan.13726 · Cited by 53 · see citing works
Nedelcu, C., Ionescu, N. S., Bizubac, A. M., Filip, C., & Cirstoveanu, C. (2025) · Life · doi:10.3390/life15101621 · Cited by 2 · see citing works
“Average ScO 2 values range between approximately 65 and 70% in both term and preterm neonates [68,69], in comparison to 46–57% in patients with cyanotic congenital heart disease [12].”
- Authors
- Cohen, E., Baerts, W., Alderliesten, T., Derks, J., Lemmers, P., & van Bel, F.
- Affiliations
- Hudson Institute of Medical Research (AU)
- Wilhelmina Children's Hospital (NL)
- Department of Neonatology, Wilhelmina Children's Hospital/University Medical Centre Utrecht, Utrecht, The Netherlands
- Corresponding author
- Cohen, Emily
- Venue
- Archives of Disease in Childhood - Fetal and Neonatal Edition
- Publisher
- BMJ
- Published
- 2015-08-26
- Volume
- 101
- Issue
- 2
- Pages
- F156-F161
- ISSN
- 1359-2998 (ISSN-L)
- 1468-2052
- OpenAlex
- W2226472557
- Cited by
- 46
- References
- 29
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 12 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 1
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- other-oa
- Locations
- Archives of Disease in Childhood Fetal & Neonatal (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- HighWire Press Open Archive (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- Universiteit Utrecht
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- fetal growth restriction, small for gestational age, preterm infants, cerebral oxygenation, regional cerebral oxygen saturation, sex differences, near-infrared spectroscopy
- MeSH terms
- Birth Weight, Brain, Female, Fetal Growth Retardation, Humans, Infant, Newborn, Infant, Premature, Infant, Small for Gestational Age, Intensive Care Units, Neonatal, Male, Oxygen, Pregnancy, Retrospective Studies, Sex Factors, Case-Control Studies, Spectroscopy, Near-Infrared
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