Cited by 46Anesthesia and Neurotoxicity ResearchAnesthesia and Sedative AgentsAnesthesia and Pain Management

Anaesthetic considerations for surgery in newborns

Houck, Constance S, Vinson, Amy E·2017·Archives of Disease in Childhood - Fetal and Neonatal Edition

Abstract

Almost 30 years ago, the American Academy of Pediatrics Committee on Fetus and Newborn coauthored a policy statement strongly advocating for the use of anaesthesia in all neonates stating 'local or systemic pharmacologic agents now available permit relatively safe administration of anesthesia or analgesia to neonates undergoing surgical procedures and that such administration is indicated according to the usual guidelines for the administration of anesthesia to high-risk, potentially unstable patients'. With current techniques and advanced monitoring, preterm and full-term infants routinely undergo surgical procedures under general anaesthesia to repair congenital defects that were lethal in years past. Recent research in immature animal models, however, has shown evidence of enhanced neuroapoptosis and other signs of neurotoxicity with all of the currently used anaesthetic agents. There is also increasing concern about the potential adverse effects of perioperative hypotension and hypocapnia on neurocognitive development in infants. This review outlines the most recent animal and human evidence regarding the effects of general anaesthesia and anaesthetic-related haemodynamic changes on the developing brain of newborns.

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Crossref · 10.1136/archdischild-2016-311800

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39 of 39 references verified0 citation errors · 0 not checkable

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  • When hemodynamic instability occurs, limited cardiac reserve increases the risk of postoperative respiratory and cardiac complications compared to other age groups.

    “When hemodynamic instability occurs, limited cardiac reserve increases the risk of postoperative respiratory and cardiac complications compared to other age groups (3).”

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Authors
Houck, C. S., & Vinson, A. E.
Affiliations
Boston Children's Hospital (US)
Corresponding author
Houck, Constance S
Venue
Archives of Disease in Childhood - Fetal and Neonatal Edition
Publisher
BMJ
Published
2017-03-10
Volume
102
Issue
4
Pages
F359-F363
ISSN
  • 1359-2998 (ISSN-L)
  • 1468-2052
OpenAlex
W2593078163
Cited by
46
References
39
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 9 · 2019: 7 · 2018: 6 · 2017: 4
FWCI
2.99
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Disease in Childhood Fetal & Neonatal (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
  • Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
Keywords
neonatal anesthesia, general anesthesia, neurotoxicity, neuronal apoptosis, anesthetic agents, perioperative hypotension, hypocapnia, neurocognitive development, preterm infants, congenital malformations, hemodynamic changes, anesthesia monitoring
MeSH terms
Anesthesia Recovery Period, Anesthesia, General, Brain, Developmental Disabilities, Humans, Infant, Newborn, Anesthetics, General, Evidence-Based Medicine

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