Effect of oxandrolone and timing of pubertal induction on final height in Turner syndrome: final analysis of the UK randomised placebo-controlled trial
Open accessAbstract
The UK Turner syndrome (TS) study examined the effect on final height of oxandrolone 0.05 mg/kg/day (maximum dose 2.5 mg) versus placebo from 9 years of age; and delaying ethinylestradiol induction of puberty by 2 years from 12 (E12) to 14 (E14) years in growth hormone-treated girls with TS. The study ran from 1999 to 2013. By 2011, eighty-two of 92 participants had reached final height and an interim analysis using the Super-Imposition by Translation And Rotation model showed significant increases in final height with both oxandrolone and E14. The analysis has been repeated now that all 92 patients have reached final height. Oxandrolone still significantly increased final height by 4.1 cm (95% CI 1.6 to 6.6, n=92) compared with 4.6 cm previously. However, the E14 effect was no longer significant at 2.7 cm (95% CI -0.8 to 6.1, n=56) compared with 3.8 cm previously.
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Addition of oxandrolone produces synergistic increases in growth response during GH treatment.
“Addition of oxandrolone, which has been used off-label for decades, produces synergistic increases in growth response during GH treatment,245-249”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [248]
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Efficacy and safety of oxandrolone in growth hormone-treated girls with Turner syndrome
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Self-citationHormone supplementation for pubertal induction in girls
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Clinical practice guidelines for the care of girls and women with Turner syndrome.
Gravholt, C. H., Andersen, N. H., Christin-Maitre, S., Davis, S. M., Duijnhouwer, A., Gawlik, A., Maciel-Guerra, A. T., Gutmark-Little, I., Fleischer, K., Hong, D., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae050 · Cited by 224 · see citing works
- Authors
- Gault, E. J., Cole, T. J., Casey, S., Hindmarsh, P. C., Betts, P., Dunger, D. B., & Donaldson, M. D. C.
- Affiliations
- University of Glasgow (GB)
- University College London (GB)
- NHS Greater Glasgow and Clyde (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- University of Cambridge (GB)
- Royal Hospital for Children (GB)
- Corresponding author
- Donaldson, Malcolm D C
- Venue
- Archives of Disease in Childhood
- Publisher
- BMJ
- Published
- 2019-12-20
- Volume
- 106
- Issue
- 1
- Pages
- 74-76
- ISSN
- 0003-9888 (ISSN-L)
- 1468-2044
- OpenAlex
- W2996568586
- Cited by
- 11
- References
- 11
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 2
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- green
- eprints.gla.ac.uk
- Licence
- cc-by-sa
- Locations
- Archives of Disease in Childhood (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- ePrints Soton (University of Southampton) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- British Society for Paediatric Endocrinology and Diabetes
- Scottish Executive Chief Scientist Office (K/MRS/50/C2713)
- National Institute for Health Research
- Child Growth Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- Turner syndrome, oxandrolone, adult height, puberty induction, ethinyl estradiol, growth hormone therapy, anabolic steroids, puberty timing
- MeSH terms
- Body Height, Child, Drug Administration Schedule, Female, United Kingdom, Humans, Male, Oxandrolone, Turner Syndrome, Treatment Outcome, Anabolic Agents
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