Determinants of disability in osteoarthritis of the knee
Open accessAbstract
Objectives To evaluate the influences of radiographic severity, quadriceps strength, knee pain, age, and gender on functional ability in patients with osteoarthritis of the knee.Methods Equal numbers of knee pain positive and negative respondents to a survey of registrants aged more than 55 years at a general practice were invited to attend for knee radiographs and quadriceps femoris isometric strength estimations. Disability was measured using the Stanford Health Assessment Questionnaire.Results Complete data were available on 70 men (mean age 72.7 years) and 89 women (mean age 68.1 years); 44% reported knee pain, 48% had radiographic features of osteoarthritis, and 32% reported some degree of disability. Significant correlations were observed between disability and radiographic score, quadriceps strength, and knee pain. Logistic regression analysis, however, showed significant independent contributions from quadriceps strength (odds ratio 0.84 kgF), knee pain (odds ratio 1.67), and age (odds ratio 1.06 per year) only; the radiographic score had no influence on the model. These results were not influenced by confining the analysis to the group with radiographic features of osteoarthritis.Conclusions Quadriceps strength, knee pain, and age are more important determinants of functional impairment in elderly subjects than the severity of knee osteoarthritis as assessed radiographically. Strategies designed to optimise muscle strength may have the potential to reduce a vast burden of disability, dependency, and cost.
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Pain and functional limitation in knee OA are closely related.
“pain and functional limitation in knee OA are closely related [64].”
From Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy (2019) · cites this paper as [64]
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- Authors
- McAlindon, T. E., Cooper, C., Kirwan, J. R., & Dieppe, P. A.
- Affiliations
- Bristol Royal Infirmary (GB)
- St Thomas' Hospital (GB)
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 1993-04
- Volume
- 52
- Issue
- 4
- Pages
- 258-262
- ISSN
- 0003-4967 (ISSN-L)
- PMC
- PMC1005622
- OpenAlex
- W2137507428
- Cited by
- 548
- References
- 24
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 12 · 2023: 8 · 2022: 15 · 2021: 21 · 2020: 21 · 2019: 16 · 2018: 16 · 2017: 16 · 2016: 19 · 2015: 20 · 2014: 25 · 2013: 22 · 2012: 19
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of the Rheumatic Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Physical Sciences › Engineering › Biomedical Engineering › Lower Extremity Biomechanics and Pathologies
- Keywords
- knee osteoarthritis, disability, functional capacity, quadriceps strength, knee pain, radiographic severity, age, sex differences, older adults, Stanford Health Assessment Questionnaire, muscle strength
- MeSH terms
- Age Factors, Aged, Disability Evaluation, Female, Humans, Knee Joint, Male, Middle Aged, Muscles, Osteoarthritis, Radiography, Regression Analysis, Sex Factors
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