Cited by 434Glaucoma and retinal disordersDrug-Induced Ocular ToxicityCerebral Venous Sinus Thrombosis

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Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex

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Gupta, N·2006·British Journal of Ophthalmology

DOI 10.1136/bjo.2005.086769PMC PMC1860237

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Abstract

The pathology of glaucoma has been extensively studied at the level of the retina and optic nerve head. Here the first clinicopathological case of human glaucoma is reported demonstrating degenerative changes in the brain involving the intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Pathological evidence of neural degeneration in this patient is correlated with clinical, optic nerve head, visual field, and neuroradiology findings. Neuropathology in the glaucoma brain is compared to age matched controls. In the presence of advanced human glaucoma with 50% visual field loss, neural damage is evident in multiple vision stations within the brain.

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Yu ¨cel YH, Zhang Q, Gupta N, et al. Loss of neurons in magnocellular and parvocellular layers of the LGN in glaucoma. Arch Ophthalmol 2000;118:378-84.

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Authors: Gupta, N.
Affiliations: St. Michael's Hospital (CA)
Corresponding author: Gupta, N
ORCID: Gupta, N
Venue: British Journal of Ophthalmology
Publisher: BMJ
Published: 2006-06-01
Volume: 90
Issue: 6
Pages: 674-678
ISSN: 0007-1161 (ISSN-L)
DOI: 10.1136/bjo.2005.086769
PMC: PMC1860237
OpenAlex: W2133684905
Cited by: 434
References: 21
Citations by year: 2026: 11 · 2025: 25 · 2024: 18 · 2023: 11 · 2022: 32 · 2021: 24 · 2020: 32 · 2019: 27 · 2018: 25 · 2017: 17 · 2016: 24 · 2015: 26 · 2014: 22 · 2013: 25 · 2012: 31
FWCI: 13.67
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: British Journal of Ophthalmology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Glaucoma Research Foundation
Glaucoma Research Society of Canada
University of Toronto
Topics: Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
Health Sciences › Medicine › Clinical Neurology › Cerebral Venous Sinus Thrombosis
Keywords: glaucoma, neurodegeneration, lateral geniculate nucleus, visual cortex, optic nerve head, visual field defects, clinicopathological correlation, neuropathology
MeSH terms: Aged, Aged, 80 and over, Brain, Female, Geniculate Bodies, Glaucoma, Open-Angle, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurons, Afferent, Optic Nerve, Optic Nerve Diseases, Visual Cortex, Visual Fields, Neurodegenerative Diseases

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Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex

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