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Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex
Open accessAbstract
The pathology of glaucoma has been extensively studied at the level of the retina and optic nerve head. Here the first clinicopathological case of human glaucoma is reported demonstrating degenerative changes in the brain involving the intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Pathological evidence of neural degeneration in this patient is correlated with clinical, optic nerve head, visual field, and neuroradiology findings. Neuropathology in the glaucoma brain is compared to age matched controls. In the presence of advanced human glaucoma with 50% visual field loss, neural damage is evident in multiple vision stations within the brain.
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Metadata
- Authors
- Gupta, N.
- Affiliations
- St. Michael's Hospital (CA)
- Corresponding author
- Gupta, N
- ORCID
- Gupta, N
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 2006-06-01
- Volume
- 90
- Issue
- 6
- Pages
- 674-678
- ISSN
- 0007-1161 (ISSN-L)
- PMC
- PMC1860237
- OpenAlex
- W2133684905
- Cited by
- 434
- References
- 21
- Citations by year
- 2026: 11 · 2025: 25 · 2024: 18 · 2023: 11 · 2022: 32 · 2021: 24 · 2020: 32 · 2019: 27 · 2018: 25 · 2017: 17 · 2016: 24 · 2015: 26 · 2014: 22 · 2013: 25 · 2012: 31
- FWCI
- 13.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Ophthalmology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Glaucoma Research Foundation
- Glaucoma Research Society of Canada
- University of Toronto
- Topics
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Health Sciences › Medicine › Clinical Neurology › Cerebral Venous Sinus Thrombosis
- Keywords
- glaucoma, neurodegeneration, lateral geniculate nucleus, visual cortex, optic nerve head, visual field defects, clinicopathological correlation, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Brain, Female, Geniculate Bodies, Glaucoma, Open-Angle, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurons, Afferent, Optic Nerve, Optic Nerve Diseases, Visual Cortex, Visual Fields, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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