The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Do the associations of sedentary behaviour with cardiovascular disease mortality and cancer mortality differ by physical activity level? A systematic review and harmonised meta-analysis of data from 850 060 participants
Abstract
Objective: To examine whether the associations between sedentary behaviours (ie, daily sitting/TV-viewing time) and mortality from cardiovascular disease (CVD) and cancer differ by different levels of physical activity (PA). Design: Harmonised meta-analysis of prospective cohort studies. Data on exposure variables were harmonised according to a predefined protocol and categorised into four groups for sedentary behaviours and into quartiles of PA (MET-hour/week). Data sources: PubMed, PsycINFO, Embase, Web of Science, Sport Discus and Scopus. Eligibility criteria for selecting studies: Individual level data on both sedentary behaviours and PA and reported effect estimates for CVD or cancer mortality. Results: Nine studies (n=850 060; deaths=25 730) and eight studies (n=777 696; deaths=30 851) provided data on sitting time and CVD and cancer mortality, respectively. Five studies had data on TV-viewing time and CVD (n=458 127; deaths=13 230) and cancer (n=458 091; deaths=16 430) mortality. A dose–response association between sitting time (9%–32% higher risk; p for trend <0.001) and TV time (3%–59% higher risk; p for trend <0.001) with CVD mortality was observed in the ‘inactive’, lowest quartile of PA. Associations were less consistent in the second and third quartiles of PA, and there was no increased risk for CVD mortality with increasing sedentary behaviours in the most active quartile. Associations between sedentary behaviours and cancer mortality were generally weaker; 6%–21% higher risk with longer sitting time observed only in the lowest quartile of PA. Conclusion: PA modifies the associations between sedentary behaviours and CVD and cancer mortality. These findings emphasise the importance of higher volumes of moderate and vigorous activity to reduce, or even eliminate these risks, especially for those who sit a lot in their daily lives.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Biswas, A., Oh, P. I., Faulkner, G. E., Bajaj, R. R., Silver, M. A., Mitchell, M. S., & Alter, D. A. (2015) · Annals of Internal Medicine · doi:10.7326/m14-1651 · Cited by 2,726
Ekelund, U., Steene-Johannessen, J., Brown, W. J., Fagerland, M. W., Owen, N., Powell, K. E., Bauman, A., & Lee, I.-M. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30370-1 · Cited by 2,648
Self-citationAssociation of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults
Moore, S. C., Lee, I.-M., Weiderpass, E., Campbell, P. T., Sampson, J. N., Kitahara, C. M., Keadle, S. K., Arem, H., Berrington de Gonzalez, A., Hartge, P., et al. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.1548 · Cited by 1,487
Self-citationPatterson, R., McNamara, E., Tainio, M., de Sá, T. H., Smith, A. D., Sharp, S. J., Edwards, P., Woodcock, J., Brage, S., & Wijndaele, K. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-018-0380-1 · Cited by 1,423
Cohort Profile: The HUNT Study, Norway
Krokstad, S., Langhammer, A., Hveem, K., Holmen, T., Midthjell, K., Stene, T., Bratberg, G., Heggland, J., & Holmen, J. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dys095 · Cited by 1,127
Daily Sitting Time and All-Cause Mortality: A Meta-Analysis
Chau, J. Y., Grunseit, A. C., Chey, T., Stamatakis, E., Brown, W. J., Matthews, C. E., Bauman, A. E., & van der Ploeg, H. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080000 · Cited by 876
Self-citationDunstan, D. W., Barr, E. L. M., Healy, G. N., Salmon, J., Shaw, J. E., Balkau, B., Magliano, D. J., Cameron, A. J., Zimmet, P. Z., & Owen, N. (2010) · Circulation · doi:10.1161/circulationaha.109.894824 · Cited by 825
Self-citationYoung, D. R., Hivert, M.-F., Alhassan, S., Camhi, S. M., Ferguson, J. F., Katzmarzyk, P. T., Lewis, C. E., Owen, N., Perry, C. K., Siddique, J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000440 · Cited by 791
Self-citationEffect of measurement error on epidemiological studies of environmental and occupational exposures
Armstrong, B. G. (1998) · Occupational and Environmental Medicine · doi:10.1136/oem.55.10.651 · Cited by 682
Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence
Kerr, J., Anderson, C., & Lippman, S. M. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30411-4 · Cited by 677
Cited by
Ekelund, U., Tarp, J., Fagerland, M. W., Johannessen, J. S., Hansen, B. H., Jefferis, B. J., Whincup, P. H., Diaz, K. M., Hooker, S., Howard, V. J., et al. (2020) · British Journal of Sports Medicine · doi:10.1136/bjsports-2020-103270 · Cited by 355
Self-citationDempsey, P. C., Biddle, S. J. H., Buman, M. P., Chastin, S., Ekelund, U., Friedenreich, C. M., Katzmarzyk, P. T., Leitzmann, M. F., Stamatakis, E., van der Ploeg, H. P., et al. (2020) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-020-01044-0 · Cited by 275
Self-citationSitting Less and Moving More: Implications for Hypertension
Dempsey, P. C., Larsen, R. N., Dunstan, D. W., Owen, N., & Kingwell, B. A. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11190 · Cited by 170
Self-citationBell, K., Shaw, J. E., Maple-Brown, L., Ferris, W., Gray, S., Murfet, G., Flavel, R., Maynard, B., Ryrie, H., Pritchard, B., et al. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108188 · Cited by 64
“[78] Ekelund U, Brown WJ, Steene-Johannessen J, Fagerland MW, Owen N, Powell KE, et al.”
Background‘SnacktivityTM’ to increase physical activity: Time to try something different?
Sanders, J. P., Biddle, S. J. H., Gokal, K., Sherar, L. B., Skrybant, M., Parretti, H. M., Ives, N., Yates, T., Mutrie, N., & Daley, A. J. (2021) · Preventive Medicine · doi:10.1016/j.ypmed.2021.106851 · Cited by 52
Metadata
- Authors
- Ekelund, U., Brown, W. J., Steene-Johannessen, J., Fagerland, M. W., Owen, N., Powell, K. E., Bauman, A. E., & Lee, I.-M.
- Venue
- British Journal of Sports Medicine
- Publisher
- BMJ
- Published
- 2018-07-10
- Volume
- 53
- Issue
- 14
- Pages
- 886-894
- ISSN
- 0306-3674 (ISSN-L)
- 1473-0480
- OpenAlex
- W2820021047
- Cited by
- 448
- References
- 28
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Do the associations of sedentary behaviour with cardiovascular disease mortality and cancer mortality differ by physical activity level? A systematic review and harmonised meta-analysis of data from 850 060 participants. https://app.cochat.ai/papers/10.1136/bjsports-2017-098963
- The paper
- Ekelund, U., Brown, W. J., Steene-Johannessen, J., Fagerland, M. W., Owen, N., Powell, K. E., Bauman, A. E., & Lee, I.-M. (2019). Do the associations of sedentary behaviour with cardiovascular disease mortality and cancer mortality differ by physical activity level? A systematic review and harmonised meta-analysis of data from 850 060 participants. British Journal of Sports Medicine. https://doi.org/10.1136/bjsports-2017-098963
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
