Sedentary Behavior and Cardiovascular Morbidity and Mortality: A Science Advisory From the American Heart Association
Abstract
Epidemiological evidence is accumulating that indicates greater time spent in sedentary behavior is associated with all-cause and cardiovascular morbidity and mortality in adults such that some countries have disseminated broad guidelines that recommend minimizing sedentary behaviors. Research examining the possible deleterious consequences of excess sedentary behavior is rapidly evolving, with the epidemiology-based literature ahead of potential biological mechanisms that might explain the observed associations. This American Heart Association science advisory reviews the current evidence on sedentary behavior in terms of assessment methods, population prevalence, determinants, associations with cardiovascular disease incidence and mortality, potential underlying mechanisms, and interventions. Recommendations for future research on this emerging cardiovascular health topic are included. Further evidence is required to better inform public health interventions and future quantitative guidelines on sedentary behavior and cardiovascular health outcomes.
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Sedentary behavior is a strong modifiable risk factor for cardiometabolic disease.
“Sedentary behavior is a strong modifiable risk factor for cardiometabolic disease [1,2].”
Greater total sedentary time is related to increased cardiometabolic risk, including decreased high-density lipoprotein levels and increased triglycerides, fasting glucose, BMI, and waist circumference.
“greater total sedentary time is related to increased cardiometabolic risk [2], including decreased high-density lipoprotein levels and increased triglycerides, fasting glucose [4], BMI, and waist circumference [5].”
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Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association
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- Authors
- Young, D. R., Hivert, M.-F., Alhassan, S., Camhi, S. M., Ferguson, J. F., Katzmarzyk, P. T., Lewis, C. E., Owen, N., Perry, C. K., Siddique, J., & Yong, C. M.
- ORCID
- Venue
- Circulation
- Published
- 2016-09-27
- Volume
- 134
- Issue
- 13
- Pages
- e262-79
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2511876639
- Semantic Scholar
- a0d5d96d81b516530ec54adfb624bc88775b70bb
- Cited by
- 791
- References
- 152
- Citations by year
- 2026: 44 · 2025: 69 · 2024: 75 · 2023: 109 · 2022: 72 · 2021: 115 · 2020: 112 · 2019: 70 · 2018: 65 · 2017: 52 · 2016: 6 · 2012: 1
- FWCI
- 51.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- sedentary behavior, cardiovascular disease, cardiovascular mortality, cardiovascular morbidity, all-cause mortality, prevalence, biological mechanisms, public health interventions
- MeSH terms
- American Heart Association, Cardiovascular Diseases, Humans, Morbidity, Motor Activity, Risk Factors, United States, Prevalence, Sedentary Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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