CoChat
Sign Up
Cited by 222

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort

Debras, Charlotte, Chazelas, Eloi, Sellem, Laury, Porcher, Raphaël, Druesne-Pecollo, Nathalie, Esseddik, Younes, de Edelenyi, Fabien Szabo, Agaësse, Cédric, De Sa, Alexandre, Lutchia, Rebecca, Fezeu, Léopold K, Julia, Chantal, Kesse-Guyot, Emmanuelle, Allès, Benjamin, Galan, Pilar, Hercberg, Serge, Deschasaux-Tanguy, Mélanie, Huybrechts, Inge, Srour, Bernard, Touvier, Mathilde·2022·BMJ
DOI 10.1136/bmj-2022-071204PMC PMC9449855
Open this paper in CoChat — free account

Abstract

Objectives: To study the associations between artificial sweeteners from all dietary sources (beverages, but also table top sweeteners, dairy products, etc), overall and by molecule (aspartame, acesulfame potassium, and sucralose), and risk of cardiovascular diseases (overall, coronary heart disease, and cerebrovascular disease). Design: Population based prospective cohort study (2009-21). Setting: France, primary prevention research. Participants: 103 388 participants of the web based NutriNet-Santé cohort (mean age 42.2±14.4, 79.8% female, 904 206 person years). Dietary intakes and consumption of artificial sweeteners were assessed by repeated 24 h dietary records, including brand names of industrial products. Main outcomes measures: Associations between sweeteners (coded as a continuous variable, log10 transformed) and cardiovascular disease risk, assessed by multivariable adjusted Cox hazard models. Results: Total artificial sweetener intake was associated with increased risk of cardiovascular diseases (1502 events, hazard ratio 1.09, 95% confidence interval 1.01 to 1.18, P=0.03); absolute incidence rate in higher consumers (above the sex specific median) and non-consumers was 346 and 314 per 100 000 person years, respectively. Artificial sweeteners were more particularly associated with cerebrovascular disease risk (777 events, 1.18, 1.06 to 1.31, P=0.002; incidence rates 195 and 150 per 100 000 person years in higher and non-consumers, respectively). Aspartame intake was associated with increased risk of cerebrovascular events (1.17, 1.03 to 1.33, P=0.02; incidence rates 186 and 151 per 100 000 person years in higher and non-consumers, respectively), and acesulfame potassium and sucralose were associated with increased coronary heart disease risk (730 events; acesulfame potassium: 1.40, 1.06 to 1.84, P=0.02; incidence rates 167 and 164; sucralose: 1.31, 1.00 to 1.71, P=0.05; incidence rates 271 and 161). Conclusions: The findings from this large scale prospective cohort study suggest a potential direct association between higher artificial sweetener consumption (especially aspartame, acesulfame potassium, and sucralose) and increased cardiovascular disease risk. Artificial sweeteners are present in thousands of food and beverage brands worldwide, however they remain a controversial topic and are currently being re-evaluated by the European Food Safety Authority, the World Health Organization, and other health agencies. Trial registration: ClinicalTrials.gov NCT03335644

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1136/bmj-2022-071204

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 19 references

Research works printed but not linked: 70

  1. 10.3389/fnut.2020.603653 · DOI
  2. 10.1016/j.mayocp.2019.05.034 · DOI · Paper page
  3. 10.1002/ffj.2074 · DOI
  4. 2020, Outcome of the public consultation on a draft protocol for assessing exposure to sweeteners as part of their safety assessment under the food additives re-evaluation programme, EFSA Supporting Publications., 17, 1913E
  5. 10.1002/oby.21327 · DOI
  6. 10.1080/17470218.2011.552729 · DOI
  7. 10.1016/j.appet.2012.10.009 · DOI
  8. 10.1016/j.acvd.2015.10.005 · DOI
  9. 10.3389/fnut.2021.746247 · DOI
  10. 10.1016/j.numecd.2020.01.014 · DOI
  11. 10.1007/s10059-011-1009-3 · DOI
  12. 10.1093/advances/nmy037 · DOI
  13. 10.3390/nu12041153 · DOI
  14. 10.1186/s13690-015-0092-x · DOI
  15. 10.1503/cmaj.161390 · DOI
  16. 10.1136/bmj.k4718 · DOI
  17. 10.1161/CIRCRESAHA.117.308903 · DOI
  18. 10.1007/s11606-014-3098-0 · DOI
  19. 10.1007/s11606-011-1968-2 · DOI · Paper page
  20. 10.1016/j.jacc.2020.08.075 · DOI
  21. 10.1161/STROKEAHA.118.023100 · DOI
  22. 10.1161/STROKEAHA.116.016027 · DOI
  23. 10.1001/jamainternmed.2019.2478 · DOI
  24. 10.1161/CIRCULATIONAHA.111.067017 · DOI · Paper page
  25. 10.1093/ajcn/nqz094 · DOI
  26. 10.3390/nu13082636 · DOI · Paper page
  27. 10.1093/advances/nmaa084 · DOI · Paper page
  28. 10.1186/1471-2458-10-242 · DOI
  29. 10.2196/jmir.2575 · DOI
  30. 10.1007/s10654-010-9433-9 · DOI
  31. 10.1007/s00038-011-0257-5 · DOI
  32. 10.1249/01.MSS.0000078924.61453.FB · DOI · Paper page
  33. 10.1249/MSS.0b013e31821ece12 · DOI · Paper page
  34. le Moullec, 1996, Validation du Manuel-photos utilisé pour l’enquête alimentaire de l’étude SU.VI.MAX, Cah Nutr Diét, 31, 158
  35. 10.1017/S0007114510004617 · DOI
  36. 10.1016/j.jand.2015.09.017 · DOI
  37. 10.1038/sj.ijo.0801376 · DOI
  38. 10.1038/sj.ejcn.1600971 · DOI
  39. Goldberg, 1991, Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. Derivation of cut-off limits to identify under-recording, Eur J Clin Nutr, 45, 569
  40. 10.1038/s41598-021-98496-6 · DOI
  41. 10.1002/sim.3841 · DOI
  42. Rodgers, 2019, 6, 19
  43. 10.1001/jamainternmed.2017.1877 · DOI
  44. 10.1001/jama.291.18.2204 · DOI
  45. 10.1093/ajcn/65.4.1220S · DOI
  46. 10.1136/bmj.f6879 · DOI · Paper page
  47. 10.1080/10408398.2021.1949575 · DOI
  48. Tournois, 2000, Autoduperie et héteroduperie: Un instrument de mesure de la désirabilité sociale. [Self-deception and other-deception: a social desirability questionnaire], European Review of Applied Psychology / Revue Européenne de Psychologie Appliquée, 50, 219
  49. 10.1136/bmj.l1451 · DOI · Paper page
  50. 10.3945/an.114.007062 · DOI
  51. 10.1136/jech-2014-205263 · DOI
  52. 10.1080/19440049.2013.851417 · DOI
  53. 10.1371/journal.pmed.1003950 · DOI · Paper page
  54. 10.1136/bmj.m688 · DOI
  55. 10.1111/ijcp.12841 · DOI · Paper page
  56. 10.1001/jamanetworkopen.2022.2092 · DOI
  57. 10.1038/nutd.2016.9 · DOI
  58. 10.1371/journal.pone.0167241 · DOI
  59. 10.3390/nu7053569 · DOI
  60. 10.3945/jn.116.230367 · DOI
  61. 10.1161/JAHA.119.015668 · DOI
  62. 10.1016/j.foodres.2021.110220 · DOI
  63. 10.1111/ijcp.12927 · DOI
  64. 10.1017/S1368980020003614 · DOI
  65. 10.1016/S1098-3597(07)80025-1 · DOI
  66. 10.1161/CIRCULATIONAHA.107.689935 · DOI · Paper page
  67. 10.1007/s11606-012-2069-6 · DOI
  68. 10.1001/jama.294.18.2330 · DOI · Paper page
  69. 10.1159/000458769 · DOI
  70. 10.1016/j.bbr.2012.04.024 · DOI

Cited by

Sorted by citations

See all 222

Metadata

Authors
Debras, C., Chazelas, E., Sellem, L., Porcher, R., Druesne-Pecollo, N., Esseddik, Y., de Edelenyi, F. S., Agaësse, C., De Sa, A., Lutchia, R., Fezeu, L. K., Julia, C., Kesse-Guyot, E., Allès, B., Galan, P., Hercberg, S., Deschasaux-Tanguy, M., Huybrechts, I., Srour, B., & Touvier, M.
Affiliations
  • Sorbonne Paris Nord University, INSERM U1153, INRAE U1125, CNAM, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Centre, University of Paris (CRESS), Bobigny, France
  • Université de Paris, CRESS UMR1153, INSERM, INRA, Paris, France
  • French network for Nutrition and Cancer Research (NACRe network), Jouy-en-Josas, France
ORCID
Debras, Charlotte
Venue
BMJ
Publisher
BMJ
Published
2022-09-07
Volume
378
Pages
e071204
ISSN
1756-1833
DOI
10.1136/bmj-2022-071204
PMC
PMC9449855
Cited by
222
References
19
Language
en
Licence
creativecommons.org/licenses/by-nc/4.0/ (unspecified)
Funders
  • H2020 European Research Council
  • Conservatoire National des Arts et Métiers
  • Institut National Du Cancer

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review