Cited by 465Smoking Behavior and CessationChronic Obstructive Pulmonary Disease (COPD) ResearchPrenatal Substance Exposure Effects

The DOI matches its Crossref record; 28 of the 31 references it cites were found in a registry or an index.

Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers.

Open access

Russell, M A, Jarvis, M, Iyer, R, Feyerabend, C·1980·BMJ

DOI 10.1136/bmj.280.6219.972

Open this paper in CoChat — free account Open PDF

Abstract

Blood nicotine and carboxyhaemoglobin (COHb) concentrations were studied in 330 smokers (206 women and 124 men). Blood nicotine concentrations in individual smokers varied from 25 to 444 nmol/l (4 to 72 ng/ml). The average concentration, 203 nmol/l (33 ng/ml), was the same in the men and the women, although cigarette consumption was higher in the men. Despite large differences in nicotine yield, there was no relation between blood nicotine concentration and the type of cigarette smoked: smokers of plain, untipped cigarettes (1.9 mg nicotine), cigarettes with unventilated filters (1.3 mg nicotine), and cigarettes with ventilated filters (0.8 mg nicotine) had similar blood nicotine concentrations. Cigarette consumption was also similar in these three groups. The correlation between blood nicotine concentration and nicotine yield of cigarette, though significant, was low (0.21, p < 0.001), showing that the nicotine yield of the cigarettes accounted for only 4.4% of the variation in blood nicotine concentrations. Similarly, the low correlation of 0.30 between COHb concentration and cigarette consumption suggests that cigarette consumption accounted for only 9% of the variation in the amount of smoke taken into the smokers' lungs. These results suggest that the assumed health advantage of switching to lower-tar and lower-nicotine cigarettes may be largely offset by the tendency of smokers to compensate by increasing inhalation. The findings of epidemiological studies showing lower risks with filter-tipped cigarettes may be attributable to other factors such as biases in the samples and changes in the quality and carcinogenicity of tobacco tar, rather than to reduced tar intake.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/bmj.280.6219.972

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Statistical principles in experimental design.
Winer, B. J. (1962) · McGraw-Hill Book Company · doi:10.1037/11774-000 · Cited by 27,137
Applied Regression Analysis
Draper, N. R., & Smith, H. (2005) · Technometrics · doi:10.1198/tech.2005.s303 · Cited by 17,993
Statistical Principles in Experimental Design.
Geisser, S., & Winer, B. J. (1963) · Journal of the American Statistical Association · doi:10.2307/2283359 · Cited by 1,934
SMOKING AND HEALTH
Fletcher, C. M. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92890-5 · Cited by 876
Changes in Bronchial Epithelium in Relation to Cigarette Smoking, 1955–1960 vs. 1970–1977
Auerbach, O., Hammond, E., & Garfinkel, L. (1979) · New England Journal of Medicine · doi:10.1056/nejm197902223000801 · Cited by 262
Tobacco and Health
Wynder, E. L., & Hoffmann, D. (1979) · New England Journal of Medicine · doi:10.1056/nejm197904193001605 · Cited by 255
Cigarette Smoking: A Dependence on High-Nicotine Boli
Russell, M. A. H., & Feyerabend, C. (1978) · Drug Metabolism Reviews · doi:10.3109/03602537808993776 · Cited by 253
Self-citation
Smoking behaviour: Physiological and psychological influences
Thornton, R. E. (1978) · Medical Entomology and Zoology · Cited by 211
Low-tar medium-nicotine cigarettes: a new approach to safer smoking.
Russell, M. A. (1976) · BMJ · doi:10.1136/bmj.1.6023.1430 · Cited by 193
Self-citation
Plasma nicotine levels after smoking cigarettes with high, medium, and low nicotine yields.
Russell, M. A., Wilson, C. M., Patel, U. A., Feyerabend, C., & Cole, P. V. (1975) · BMJ · doi:10.1136/bmj.2.5968.414 · Cited by 192
Self-citation

Show all 31 references

Research works printed but not linked: 3

Gori GB, Lynch CJ. Towards less hazardous cigarettes. J3AMA 1978; 240:1255-9. 3World Health Organisat;on. Controlling the smoking epidemic. WHO Tech Rep Ser 1979;636.
Creighton DE, Lewis PH. The effect of different cigarettes on human smoking patterns. In: Thornton RE, ed. Smoking behaviour: physiological andpsychological influences. London: Churchill Livingstone, 1978: 289-300.
Rawbone RG, Murphy K, Tate ME, Kane SJ. The analysis of smoking parameters, inhalation and absorption of tobacco smoke in studies of human smoking behaviour. In: Thornton RE, ed. Smoking behaviour: physiological and psychological influences. London: Churchill Livingstone, 1978:171-94.

Sorted by citations

Metabolism and Disposition Kinetics of Nicotine
Hukkanen, J., Jacob, P., & Benowitz, N. L. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.3 · Cited by 1,583
The Theory of Risk Homeostasis: Implications for Safety and Health
Wilde, G. J. S. (1982) · Risk Analysis · doi:10.1111/j.1539-6924.1982.tb01384.x · Cited by 1,179
Pharmacologic Aspects of Cigarette Smoking and Nicotine Addiction
Oates, J. A., Wood, A. J. J., & Benowitz, N. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198811173192005 · Cited by 969
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells
West, K. A., Brognard, J., Clark, A. S., Linnoila, I. R., Yang, X., Swain, S. M., Harris, C. C., Belinsky, S. A., & Dennis, P. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16147 · Cited by 577
Smokers of Low-Yield Cigarettes Do Not Consume Less Nicotine
Benowttz, N. L., Hall, S. M., Herning, R. I., Jacob, P., Jones, R. T., & Osman, A.-L. (1983) · New England Journal of Medicine · doi:10.1056/nejm198307213090303 · Cited by 442
Nicotine and smoking: A review of effects on human performance.
Heishma, S. J., Taylor, R. C., & Henningfield, J. E. (1994) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.2.4.345 · Cited by 369
Nicotine-Mediated Cell Proliferation and Tumor Progression in Smoking-Related Cancers
Schaal, C. M., & Chellappan, S. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0541 · Cited by 355
Nicotine-induced upregulation of nicotinic receptors: Underlying mechanisms and relevance to nicotine addiction
Govind, A. P., Vezina, P., & Green, W. N. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.06.011 · Cited by 338
Effects of cigarette smoking on reproduction
Dechanet, C., Anahory, T., Mathieu-Daudé, J. C., Quantin, X., Reyftmann, L., Hamamah, S., Hedon, B., & Déchaud, H. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq033 · Cited by 324
Tobacco components stimulate Akt-dependent proliferation and NFκB-dependent survival in lung cancer cells
Tsurutani, J., Castillo, S. S., Brognard, J., Granville, C. A., Zhang, C., Gills, J. J., Sayyah, J., & Dennis, P. A. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi072 · Cited by 291
Smoking behaviour and compensation: a review of the literature
Scherer, G. (1999) · Psychopharmacology · doi:10.1007/s002130051027 · Cited by 257
Human Vascular Endothelial Cells Express Functional Nicotinic Acetylcholine Receptors
Macklin, K. D., Maus, A. D. J., Pereira, E. F. R., Albuquerque, E. X., & Conti‐Fine, B. M. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37807-3 · Cited by 247
Leukocyte Count, Smoking, and Myocardial Infarction
Zalokar, J. B., Richard, J. L., & Claude, J. R. (1981) · New England Journal of Medicine · doi:10.1056/nejm198102193040806 · Cited by 245
Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro
Villablanca, A. C. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.6.2089 · Cited by 227
Effects of nicotine on body weight and food consumption in rats
Grunberg, N. E., Bowen, D. J., & Morse, D. E. (1984) · Psychopharmacology · doi:10.1007/bf00427430 · Cited by 227
Influence of Smoking Fewer Cigarettes on Exposure to Tar, Nicotine, and Carbon Monoxide
Benowitz, N. L., Jacob, P., Kozlowski, L. T., & Yu, L. (1986) · New England Journal of Medicine · doi:10.1056/nejm198611203152102 · Cited by 213
Maternal cigarette smoking during pregnancy is associated with downregulation ofmiR-16,miR-21, andmiR-146ain the placenta
Maccani, M. A., Avissar-Whiting, M., Banister, C. E., McGonnigal, B., Padbury, J. F., & Marsit, C. J. (2010) · Epigenetics · doi:10.4161/epi.5.7.12762 · Cited by 206
Nicotine and Carbonyl Emissions From Popular Electronic Cigarette Products: Correlation to Liquid Composition and Design Characteristics
Hellani, A. E., Salman, R., El-Hage, R., Talih, S., Malek, N., Baalbaki, R., Karaoghlanian, N. V., Nakkash, R. T., Shihadeh, A., & Saliba, N. A. (2016) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntw280 · Cited by 206
Excess mortality among cigarette smokers: changes in a 20-year interval.
Thun, M. J., Day-Lally, C. A., Calle, E. E., Flanders, W. D., & Heath, C. W. (1995) · American Journal of Public Health · doi:10.2105/ajph.85.9.1223 · Cited by 203
Nicotine Yield From Machine-Smoked Cigarettes and Nicotine Intakes in Smokers: Evidence From a Representative Population Survey
Jarvis, M. J., Boreham, R., Primatesta, P., Feyerabend, C., & Bryant, A. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.2.134 · Cited by 203
Self-citation
Nicotine and Cotinine Modulate Cerebral Microvascular Permeability and Protein Expression of ZO-1 through Nicotinic Acetylcholine Receptors Expressed on Brain Endothelial Cells
Abbruscato, T. J., Lopez, S. P., Mark, K. S., Hawkins, B. T., & Davis, T. P. (2002) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10256 · Cited by 182
Receptor‐mediated tobacco toxicity: cooperation of the Ras/Raf‐1/MEK1/ERK and JAK‐2/STAT‐3 pathways downstream of a7 nicotinic receptor in oral keratinocytes
Arredondo, J., Chernyavsky, A. I., Jolkovsky, D. L., Pinkerton, K. E., & Grando, S. A. (2006) · The FASEB Journal · doi:10.1096/fj.06-6191com · Cited by 183
Gender differences in tobacco use.
Grunberg, N. E., Winders, S. E., & Wewers, M. E. (1991) · Health Psychology · doi:10.1037/0278-6133.10.2.143 · Cited by 181
Neuronal nicotinic receptors in non-neuronal cells: new mediators of tobacco toxicity?
Conti‐Fine, B. M., Navaneetham, D., Lei, S., & Maus, A. D. J. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00036-4 · Cited by 174
Self-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects
Dawkins, L., Kimber, C., Doig, M. V., Feyerabend, C., & Corcoran, O. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4338-2 · Cited by 168
Self-citation
Nicotine pharmacokinetics and its application to intake from smoking.
Feyerabend, C., Ings, R., & Russel, M. A. (1985) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1985.tb02637.x · Cited by 167
Self-citation
Role of training dose in discrimination of nicotine and related compounds by rats
Stolerman, I. P., Garcha, H. S., Pratt, J. A., & Kumar, R. C. (1984) · Psychopharmacology · doi:10.1007/bf00555223 · Cited by 164
Nicotine and cotinine concentrations in serum and milk of nursing smokers.
Luck, W., & Nau, H. (1984) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1984.tb05014.x · Cited by 161
Nicotine induced changes in gene expression by human coronary artery endothelial cells
Zhang, S., Day, I. N. M., & Ye, S. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00475-5 · Cited by 161
Nicotine: Carcinogenicity and Effects on Response to Cancer Treatment – A Review
Sanner, T., & Grimsrud, T. K. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00196 · Cited by 156
Stimulation of [3H]Dopamine Release by Nicotine in Rat Nucleus Accumbens
Rowell, P. P., Carr, L. A., & Garner, A. C. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb01013.x · Cited by 154
Smoking and reproduction: The oviduct as a target of cigarette smoke
Talbot, P., & Riveles, K. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-52 · Cited by 146
Cigarette Filter Ventilation and its Relationship to Increasing Rates of Lung Adenocarcinoma
Song, M., Benowitz, N. L., Berman, M. L., Brasky, T. M., Cummings, K. M., Hatsukami, D. K., Marian, C., O’Connor, R. J., Rees, V. W., Woroszyło, C., et al. (2017) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djx075 · Cited by 146
Smoking cessation increases gingival blood flow and gingival crevicular fluid
Morozumi, T., Kubota, T., Sato, T., Okuda, K., & Yoshie, H. (2004) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2004.00476.x · Cited by 146
Firsthand cigarette smoke alters fibroblast migration and survival: Implications for impaired healing
Wong, L. S., & Martins‐Green, M. (2004) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2004.12403.x · Cited by 135
Nicotine concentrations in urine and saliva of smokers and non-smokers.
Feyerabend, C., Higenbottam, T., & Russell, M. A. (1982) · BMJ · doi:10.1136/bmj.284.6321.1002 · Cited by 133
Self-citation
Ambulatory 24-h blood pressure monitoring in healthy, middle-aged smokeless tobacco users, smokers, and nontobacco users☆
Bolinder, G., & DeFaire, U. (1998) · American Journal of Hypertension · doi:10.1016/s0895-7061(98)00137-x · Cited by 132
Differential Effects of Nicotine and Smoke Condensate on Bone Cell Metabolic Activity
Gullihorn, L., Karpman, R. R., & Lippiello, L. (2005) · Journal of Orthopaedic Trauma · doi:10.1097/00005131-200501000-00004 · Cited by 131
Association between leukocyte count and the presence and extent of coronary atherosclerosis as determined by coronary arteriography
Kostis, J. B., Turkevich, D., & Sharp, J. (1984) · The American Journal of Cardiology · doi:10.1016/0002-9149(84)90624-6 · Cited by 129
Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-κB
Iho, S., Tanaka, Y., Takauji, R., Kobayashi, C., Muramatsu, I., Iwasaki, H., Nakamura, K., Sasaki, Y., Nakao, K., & Takahashi, T. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.1202626 · Cited by 128
Carboxyhemoglobin and thiocyanate as biomarkers of exposure to carbon monoxide and hydrogen cyanide in tobacco smoke
Scherer, G. (2006) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2006.07.001 · Cited by 127
Gender differences in the pharmacology of nicotine addiction
Benowitz, N. L., & Hatsukami, D. K. (1998) · Addiction Biology · doi:10.1080/13556219871930 · Cited by 125
Effect of Birth Weight and Maternal Smoking on Cord Blood Leptin Concentrations of Full-Term and Preterm Newborns
Mantzoros, C. S., Varvarigou, A. A., Kaklamani, V., Beratis, N. G., & Flier, J. S. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.9.4248 · Cited by 124
Clinical use of nicotine chewing-gum.
Russell, M. A., Raw, M., & Jarvis, M. J. (1980) · BMJ · doi:10.1136/bmj.280.6231.1599 · Cited by 123
Self-citation
Nicotine Persistently Activates Ventral Tegmental Area Dopaminergic Neurons via Nicotinic Acetylcholine Receptors Containing α4 and α6 Subunits
Liu, L., Zhao-Shea, R., McIntosh, J. M., Gardner, P. D., & Tapper, A. R. (2012) · Molecular Pharmacology · doi:10.1124/mol.111.076661 · Cited by 125
Nicotine Is a Potent Blocker of the Cardiac A-Type K+Channels
Wang, H., Shi, H., Zhang, L., Pourrier, M., Yang, B., Nattel, S., & Wang, Z. (2000) · Circulation · doi:10.1161/01.cir.102.10.1165 · Cited by 121
Discriminative stimulus properties of nicotine: Further evidence for mediation at a cholinergic receptor
Pratt, J. A., Stolerman, I. P., Garcha, H. S., Giardini, V., & Feyerabend, C. (1983) · Psychopharmacology · doi:10.1007/bf00439274 · Cited by 121
Self-citation
(S)-(−)-cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H]dopamine release from rat striatal slices in a calcium-dependent manner
Dwoskin, L. P., Teng, L., Buxton, S. T., & Crooks, P. A. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38040-1 · Cited by 120
Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking
Crooks, P. A., & Dwoskin, L. P. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00117-2 · Cited by 118
Nicotine's role in smoking: An analysis of nicotine regulation.
McMorrow, M. J., & Foxx, R. M. (1983) · Psychological Bulletin · doi:10.1037/0033-2909.93.2.302 · Cited by 118
Cigarette Advertising and Media Coverage of Smoking and Health
Warner, K. E. (1985) · New England Journal of Medicine · doi:10.1056/nejm198502073120627 · Cited by 116
Cigarette smoke inhibits oocyte cumulus complex pick-up by the oviduct in vitro independent of ciliary beat frequency
Knoll, M. F., & Talbot, P. (1998) · Reproductive Toxicology · doi:10.1016/s0890-6238(97)00100-7 · Cited by 115
Degeneration of intervertebral discs due to smoking: experimental assessment in a rat-smoking model
Oda, H., Matsuzaki, H., Tokuhashi, Y., Wakabayashi, K., Uematsu, Y., & Iwahashi, M. (2004) · Journal of Orthopaedic Science · doi:10.1007/s00776-003-0759-y · Cited by 115
Cigarette smoke elicits leukocyte adhesion to endothelium in hamsters: Inhibition by CuZn-SOD
Lehr, H., Kress, E., Menger, M. D., Friedl, H. P., Hübner, C., Arfors, K. E., & Meßmer, K. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90138-k · Cited by 115
Nicotine-Mediated Activation of Dopaminergic Neurons in Distinct Regions of the Ventral Tegmental Area
Zhao-Shea, R., Liu, L., Soll, L. G., Improgo, M. R., Meyers, E. E., McIntosh, J. M., Grady, S. R., Marks, M. J., Gardner, P. D., & Tapper, A. R. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.240 · Cited by 123
Cotinine validation of self-reported smoking in commercially run community surveys
Pierce, J. P., Dwyer, T., Digiusto, E., Carpenter, T., Hannam, C. D., Amin, A., Yong, C., Sarfaty, G. A., Shaw, J., & Burke, N. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90105-6 · Cited by 112
Nicotine and apoptosis
Zeidler, R., Albermann, K., & Lang, S. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0102-8 · Cited by 107
Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFκB activation and cyclin D1 up-regulation
Ho, Y., CHEN, C., Wang, Y., Pestell, R. G., ALBANESE, C., Chen, R., Chang, M., Jeng, J., Lin, S., & Liang, Y. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.09.019 · Cited by 107
Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells
Carlisle, D. L., Liu, X., Hopkins, T. M., Swick, M. C., Dhir, R., & Siegfried, J. M. (2006) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2006.07.001 · Cited by 106
In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation
Cormier, A., Morin, C., Zini, R., Tillement, J. P., & Lagrue, G. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02254-5 · Cited by 106
Upregulation of nicotinic receptors following continuous infusion of nicotine is brain-region-specific
Sanderson, E. M., Drasdo, A. L., McCrea, K. E., & Wonnacott, S. (1993) · Brain Research · doi:10.1016/0006-8993(93)91104-z · Cited by 106
Nicotine and Addiction
SLADE, J. D. (1995) · JAMA · doi:10.1001/jama.1995.03530030045033 · Cited by 105
Nicotine and Carbon Monoxide Content of Cigarette Smoke and the Risk of Myocardial Infarction in Young Men
Kaufman, D. W., Helmrich, S. P., Rosenberg, L. A., Miettinen, O. S., & Shapiro, S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198302243080801 · Cited by 105
β-Carotene Supplementation and Lung Cancer Incidence in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: The Role of Tar and Nicotine
Middha, P., Weinstein, S. J., Männistö, S., Albanes, D., & Mondul, A. M. (2019) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty115 · Cited by 104
Central Role of Fibroblast α3 Nicotinic Acetylcholine Receptor in Mediating Cutaneous Effects of Nicotine
Arredondo, J., Hall, L. L., Ndoye, A., Nguyen, V. T., Chernyavsky, A. I., Bercovich, D., Orr‐Urtreger, A., Beaudet, A. L., & Grando, S. A. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000053917.46614.12 · Cited by 104
Genotoxic and Antiapoptotic Effect of Nicotine on Human Gingival Fibroblasts
Argentin, G. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh061 · Cited by 104
Validation of smoking status in clinical research into inflammatory periodontal disease
Scott, D. A., Palmer, R. M. J., & Stapleton, J. (2001) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2001.280801.x · Cited by 104
Analytical cigarette yields as predictors of smoke bioavailability
Gori, G. B., & Lynch, C. J. (1985) · Regulatory Toxicology and Pharmacology · doi:10.1016/0273-2300(85)90045-5 · Cited by 103
Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H2O2 and entailing Glyoxalase 1-dependent MG-H1 accumulation leading to TG2-mediated NF-kB desensitization: Implication for smokers-related osteoporosis
Marinucci, L., Balloni, S., Fettucciari, K., Bodo, M., Talesa, V. N., & Antognelli, C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.017 · Cited by 101
Nicotine Induces Tumor Growth and Chemoresistance through Activation of the PI3K/Akt/mTOR Pathway in Bladder Cancer
Yuge, K., Kikuchi, E., Hagiwara, M., Yasumizu, Y., Tanaka, N., Kosaka, T., Miyajima, A., & Oya, M. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0140 · Cited by 99
Mechanisms Underlying Cerebrovascular Effects of Cigarette Smoking in Rats In Vivo
Iida, M., Iida, H., Dohi, S., Takenaka, M., & Fujiwara, H. (1998) · Stroke · doi:10.1161/01.str.29.8.1656 · Cited by 98
An Ethyl Acetate Fraction of Moringa oleifera Lam. Inhibits Human Macrophage Cytokine Production Induced by Cigarette Smoke
Kooltheat, N., Sranujit, R. P., Chumark, P., Potup, P., Laytragoon‐Lewin, N., & Usuwanthim, K. (2014) · Nutrients · doi:10.3390/nu6020697 · Cited by 102
Potential mechanisms of susceptibility to periodontitis in tobacco smokers
Palmer, R. M. J., Scott, D. A., Meekin, T. N., Poston, R. N., Odell, E. W., & Wilson, R. F. (1999) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1999.tb02267.x · Cited by 95
Effects of prenatal nicotine exposure on rat striatal dopaminergic and nicotinic systems
Fung, Y. K., & Lau, Y. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90419-x · Cited by 95
Hyperaemic response to cigarette smoking in healthy gingiva
Mavropoulos, A., Aars, H., & Brodin, P. (2003) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2003.10284.x · Cited by 94
Chronic exposure to e-cig aerosols during early development causes vascular dysfunction and offspring growth deficits
Orzabal, M. R., Lunde-Young, E. R., Ramirez, J. I., Howe, S. Y. F., Naik, V. D., Lee, J., Heaps, C. L., Threadgill, D. W., & Ramadoss, J. (2019) · Translational Research · doi:10.1016/j.trsl.2019.01.001 · Cited by 91
Opposing Actions of Ethanol and Nicotine on Micro RNA s are Mediated by Nicotinic Acetylcholine Receptors in Fetal Cerebral Cortical–Derived Neural Progenitor Cells
Balaraman, S., Winzer‐Serhan, U. H., & Miranda, R. C. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01793.x · Cited by 90
Chronic exposure to nicotine alters endothelium-dependent arteriolar dilatation: effect of superoxide dismutase
Mayhan, W. G., & Sharpe, G. M. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.4.1126 · Cited by 88
A Receptor-Mediated Mechanism of Nicotine Toxicity in Oral Keratinocytes
Arredondo, J., Nguyen, V. T., Chernyavsky, A. I., Jolkovsky, D. L., Pinkerton, K. E., & Grando, S. A. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780379 · Cited by 88
Interactions between arbuscular mycorrhizal fungi, rhizobacteria, soil phosphorus and plant cytokinin deficiency change the root morphology, yield and quality of tobacco
Cosme, M., & Wurst, S. (2012) · Soil Biology and Biochemistry · doi:10.1016/j.soilbio.2012.09.024 · Cited by 86
Ciliary Beat Frequency of Hamster Oviducts is Decreased in Vitro by Exposure to Solutions of Mainstream and Sidestream Cigarette Smoke1
Knoll, M. F., Shaoulian, R., Magers, T., & Talbot, P. (1995) · Biology of Reproduction · doi:10.1095/biolreprod53.1.29 · Cited by 86
Cigarette Smoke Enhances Ethanol-Induced Pancreatic Injury
Hartwig, W., Werner, J., Ryschich, E., Mayer, H., Schmidt, J., Gebhard, M. M., Herfarth, C. H., & Klar, E. (2000) · Pancreas · doi:10.1097/00006676-200010000-00009 · Cited by 86
Changes in Mortality from Smoking in Two American Cancer Society Prospective Studies since 1959
Thun, M. J., & Heath, C. W. (1997) · Preventive Medicine · doi:10.1006/pmed.1997.0182 · Cited by 85
Behavioral Pharmacology of Cigarette Smoking
Henningfield, J. E. (1984) · Advances in behavioral pharmacology · doi:10.1016/b978-0-12-004704-8.50011-0 · Cited by 85
Receptor-Mediated Tobacco Toxicity
Arredondo, J., Chernyavsky, A. I., Marubio, L. M., Beaudet, A. L., Jolkovsky, D. L., Pinkerton, K. E., & Grando, S. A. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62281-x · Cited by 84
Relationship between cigarette yields, puffing patterns, and smoke intake: evidence for tar compensation?
Sutton, S. R., Russell, M. A., Iyer, R., Feyerabend, C., & Saloojee, Y. (1982) · BMJ · doi:10.1136/bmj.285.6342.600 · Cited by 84
Self-citation
Estimating the Yield to Smokers of Tar, Nicotine, and Carbon Monoxide from the ‘Lowest Yield’Ventilated Filter‐Cigarettes
Kozlowski, L. T., Rickert, W. S., Pope, M. A., Robinson, J. C., & Frecker, R. C. (1982) · British Journal of Addiction · doi:10.1111/j.1360-0443.1982.tb01417.x · Cited by 84
A role for the basal ganglia in nicotinic modulation of the blink reflex
Evinger, C. L., Basso, M., Manning, K., Sibony, P. A., Pellegrini, J., & Horn, A. E. (1993) · Experimental Brain Research · doi:10.1007/bf00229040 · Cited by 83
Nicotine and cotinine concentrations in the milk of smoking mothers: influence of cigarette consumption and diurnal variation
Luck, W., & Nau, H. (1987) · European Journal of Pediatrics · doi:10.1007/bf00647276 · Cited by 82
Absorption of nicotine and carbon monoxide from passive smoking under natural conditions of exposure.
Jarvis, M. J., Russell, M. A., & Feyerabend, C. (1983) · Thorax · doi:10.1136/thx.38.11.829 · Cited by 82
Self-citation
Oral administration of nicotine: Its uptake and distribution after chronic administration to mice
Rowell, P. P., Hurst, H. E., Marlowe, C., & Bennett, B. D. (1983) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(83)90064-5 · Cited by 81
Tobacco extract but not nicotine impairs the mechanical strength of fracture healing in rats
Skott, M., Andreassen, T. T., Ulrich‐Vinther, M., Chen, X., Keyler, D. E., LeSage, M. G., Pentel, P. R., Bechtold, J. E., & Søballé, K. (2006) · Journal of Orthopaedic Research® · doi:10.1002/jor.20187 · Cited by 80
Puffing topography as a determinant of smoke exposure
Bridges, R. B., Combs, J. G., Humble, J. W., Turbek, J. A., Rehm, S. R., & Haley, N. J. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90037-i · Cited by 79
Nicotine induces fibrogenic changes in human liver via nicotinic acetylcholine receptors expressed on hepatic stellate cells
Soeda, J., Morgan, M. L., McKee, C. M., Mouralidarane, A., Lin, C., Roskams, T., & Oben, J. A. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.151 · Cited by 78
Nicotine, resorption and fate
Schievelbein, H. (1982) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(82)90068-7 · Cited by 78
Role of α7-nicotinic acetylcholine receptor in nicotine-induced invasion and epithelial-to-mesenchymal transition in human non-small cell lung cancer cells
Zhang, C., Ding, X., Zhao, Q., Yang, X., An, S.-M., Wang, H., Xu, L., Zhu, L., & Chen, H. (2016) · Oncotarget · doi:10.18632/oncotarget.10498 · Cited by 78
Nicotine prolongs neutrophil survival by suppressing apoptosis
Aoshiba, K., Nagai, A., Yasui, S., & Konno, K. (1996) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(96)90077-3 · Cited by 77
Genetic dissociation of two behaviors associated with nicotine addiction: Beta-2 containing nicotinic receptors are involved in nicotine reinforcement but not in withdrawal syndrome
Besson, M., David, V., Suarez, S., Cormier, A., Cazala, P., Changeux, J.-P., & Granon, S. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0418-z · Cited by 73
Effects of a restricted work-site smoking policy on employees who smoke.
Brigham, J., Gross, J., Stitzer, M. L., & Felch, L. J. (1994) · American Journal of Public Health · doi:10.2105/ajph.84.5.773 · Cited by 73
Histological changes in intervertebral discs after smoking cessation: experimental study using a rat passive smoking model
Nemoto, Y., Matsuzaki, H., Tokuhasi, Y., Okawa, A., Uematu, Y., Nishimura, T., & Oda, H. (2006) · Journal of Orthopaedic Science · doi:10.1007/s00776-005-0987-4 · Cited by 72

Authors: Russell, M. A., Jarvis, M., Iyer, R., & Feyerabend, C.
Affiliations: Maudsley Hospital (GB)
ORCID: Russell, M A
Jarvis, M
Venue: BMJ
Publisher: BMJ
Published: 1980-04-05
Volume: 280
Issue: 6219
Pages: 972-976
ISSN: 0007-1447 (ISSN-L)
1468-5833
DOI: 10.1136/bmj.280.6219.972
OpenAlex: W2013217130
Cited by: 465
References: 31
Citations by year: 2026: 4 · 2025: 9 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 13 · 2015: 7 · 2014: 13 · 2013: 11 · 2012: 16
FWCI: 22.12
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
Locations: BMJ (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords: nicotine yield, carboxyhemoglobin, cigarette smoking, cigarette filters, cigarette consumption, tobacco tar, sex differences
MeSH terms: Carboxyhemoglobin, Female, Humans, Male, Nicotine, Plants, Toxic, Sex Factors, Smoking, Tars, Nicotiana

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks