Cited by 2,213Sodium Intake and HealthBlood Pressure and Hypertension StudiesRenin-Angiotensin System Studies

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. Intersalt Cooperative Research Group.

Open access
Scally, Gabriel·1988·BMJ

Abstract

The relations between 24 hour urinary electrolyte excretion and blood pressure were studied in 10,079 men and women aged 20-59 sampled from 52 centres around the world based on a highly standardised protocol with central training of observers, a central laboratory, and extensive quality control. Relations between electrolyte excretion and blood pressure were studied in individual subjects within each centre and the results of these regression analyses pooled for all 52 centres. Relations between population median electrolyte values and population blood pressure values were also analysed across the 52 centres. Sodium excretion ranged from 0.2 mmol/24 h (Yanomamo Indians, Brazil) to 242 mmol/24 h (north China). In individual subjects (within centres) it was significantly related to blood pressure. Four centres found very low sodium excretion, low blood pressure, and little or no upward slope of blood pressure with age. Across the other 48 centres sodium was significantly related to the slope of blood pressure with age but not to median blood pressure or prevalence of high blood pressure. Potassium excretion was negatively correlated with blood pressure in individual subjects after adjustment for confounding variables. Across centres there was no consistent association. The relation of sodium to potassium ratio to blood pressure followed a pattern similar to that of sodium. Body mass index and heavy alcohol intake had strong, significant independent relations with blood pressure in individual subjects.

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Crossref · 10.1136/bmj.297.6644.319

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Citations

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Research works printed but not linked: 11

  1. Elliott P, Forrest RD, Jackson CA, Yudkin IS. Sodium and blood pressure: positive associations in a north London population with consideration of the methodological problems of within-population surveys. J7ournal of Human Hliperiensioln (in press).
  2. Grobbee DE, Hofman A. Does sodium restriction lower blood pressure? BrMed,7 1986;293:27-9.
  3. Dahl L. Possible role of salt intake in the development of hypertension. In: Cottier P, Bock KD, eds. Essential hypertension-an international symposium. Berlin: Springer Verlag, 1960:53-65.
  4. Froment A, Milon H, Gravier C. Relationship of sodium intake and arterial hypertension. Contribution of geographical epidemiology. Rev Epidemiol Sante Publique 1979;27:437-54.
  5. Joossens JV. Relation entre l'epidemiologie des accidents cerebrovasculaires et celle du cancer de l'estomac. Evolution Medicale 1968;234:381-5.
  6. Elliott 1P, Stamler R. Manual of operations for INTERSALT. Controlled Clin Trials 1988;9:1-118S.
  7. Wright BM, Dore CF. A randoni zero sphygmomanometer. Lancet 1970;i: 337-8.
  8. American Association of Clinical Chemists. Standard methods of clinical chemisov. Vol 3. New York: Academic Press, 1961.
  9. Jaffe M. Uber den Niederschlag welchen Pikrinsaure in normalen Harn erzeugt und uber eine neue Reaction des Kreatinins. Zeitschrift fur Ph-siologische Chemie 1886;10: 391-400.
  10. Fleiss JL. The design and analysts ofclinical expertments. New York: John Wiley and Sons, 1986:1-32.
  11. Kaelber CT, Barboriak J, guest eds. Symposium on alcohol and cardiovascular diseases. Circulatltion 1981;64(suppl III):III 1-84.

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Metadata

Authors
Scally, G.
Corresponding author
Scally, Gabriel
Venue
BMJ
Publisher
BMJ
Published
1988-07-30
Volume
297
Issue
6644
Pages
319-328
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
OpenAlex
W1481480932
Cited by
2,213
References
19
Citations by year
2026: 30 · 2025: 66 · 2024: 71 · 2023: 56 · 2022: 76 · 2021: 101 · 2020: 90 · 2019: 73 · 2018: 77 · 2017: 94 · 2016: 87 · 2015: 91 · 2014: 106 · 2013: 95 · 2012: 90
FWCI
40.12
Type
journal article
Language
en
Open access
Locations
  • BMJ (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • UWE Research Repository (UWE Bristol) (submittedVersion, cc-by)
Funders
Wellcome Trust
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
sodium excretion, potassium excretion, blood pressure, salt sensitivity, Na+/K+ ratio, age-related blood pressure increase, body mass index, alcohol consumption, hypertension prevalence
MeSH terms
Adult, Age Factors, Alcohol Drinking, Blood Pressure, Body Height, Body Weight, Cross-Cultural Comparison, Female, Humans, Hypertension, Male, Middle Aged, Potassium, Regression Analysis, Sex Factors, Sodium, Statistics as Topic

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