Cited by 279Stress Responses and CortisolAdrenal Hormones and DisordersTreatment of Major Depression

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Resistance to Suppression by Dexamethasone of Plasma 11-O.H.C.S. Levels in Severe Depressive Illness

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Carroll, B. J., Martin, F. I. R., Davies, Brian·1968·BMJ

DOI 10.1136/bmj.3.5613.285PMC PMC1986248

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Abstract

Use of the midnight dexamethasone suppression test showed that the plasma 11-hydroxycorticosteroid (11-O.H.C.S.) level did not undergo its normal reduction in 14 out of 27 patients with severe depression. Resistance to dexamethasone suppression correlated with the clinical rating of the severity of depression, while recovery from depression was associated with return of normal responsiveness to dexamethasone. The explanation of these findings is unknown.

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Authors: Carroll, B. J., Martin, F. I. R., & Davies, B.
Affiliations: The Royal Melbourne Hospital (AU)
ORCID: Carroll, B. J.
Venue: BMJ
Publisher: BMJ
Published: 1968-08-03
Volume: 3
Issue: 5613
Pages: 285-287
ISSN: 0007-1447 (ISSN-L)
1468-5833
DOI: 10.1136/bmj.3.5613.285
PMC: PMC1986248
OpenAlex: W2055891857
Cited by: 279
References: 10
Citations by year: 2026: 1 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 4 · 2013: 14 · 2012: 5
FWCI: 5.84
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
Locations: BMJ (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: dexamethasone suppression test, 11-hydroxycorticosteroids, plasma corticosteroid levels, depression, severe depression, hypothalamic-pituitary-adrenal axis, depression severity, recovery from depression, glucocorticoid resistance
MeSH terms: Adolescent, Adult, Aged, Anorexia Nervosa, Anxiety, Circadian Rhythm, Depression, Dexamethasone, Fatigue, Mental Fatigue, Female, Fluorometry, Glucocorticoids, Humans, Male, Middle Aged, Pituitary-Adrenal Function Tests, Time Factors

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Resistance to Suppression by Dexamethasone of Plasma 11-O.H.C.S. Levels in Severe Depressive Illness

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