Cited by 40Bipolar Disorder and TreatmentSuicide and Self-Harm StudiesPsychopathy, Forensic Psychiatry, Sexual Offending

Neurobiological aspects of suicide and suicide attempts in bipolar disorder

Open access
Mathews, Daniel, Richards, Erica, Niciu, Mark, Ionescu, Dawn, Rasimas, Joseph, Zarate, Carlos·2013·Translational Neuroscience

Abstract

Suicide and bipolar disorder (BD) are challenging, complex, and intertwined areas of study in contemporary psychiatry. Indeed, BD is associated with the highest lifetime risk for suicide attempt and completion of all the psychiatric conditions. Given that several clinical risk factors for both suicide and BD have been well noted in the literature, exploring the neurobiological aspects of suicide in BD may provide insights into both preventive measures and future novel treatments. This review synthesizes findings regarding the neurobiological aspects of suicide and, when applicable, their link to BD. Neurochemical findings, genes/epigenetics, and potential molecular targets for current or future treatments are discussed. The role of endophenotypes and related proximal and distal risk factors underlying suicidal behavior are also explored. Lastly, we discuss the manner in which preclinical work on aggression and impulsivity may provide additional insights for the future development of novel treatments.

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  • Depressed suicide decedents have fewer brain-projecting noradrenergic neurons in the rostral locus coeruleus and higher β-adrenergic receptor binding in the PFC, consistent with less noradrenergic activity.

    “Depressed suicide decedents have fewer brain-projecting noradrenergic neurons in the rostral locus coeruleus and higher β-adrenergic receptor binding in the PFC, both consistent with less noradrenergic activity.”

    From A brain-centric model of suicidal behavior (2020) · cites this paper as [126]

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Authors
Mathews, D., Richards, E., Niciu, M., Ionescu, D., Rasimas, J., & Zarate, C.
Affiliations
National Institutes of Health (US)
Venue
Translational Neuroscience
Published
2013-06-01
Volume
4
Issue
2
Pages
203-216
ISSN
  • 2081-3856 (ISSN-L)
  • 2081-6936
OpenAlex
W2046908495
Cited by
39
References
209
Citations by year
2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 4
FWCI
3.79
Type
journal article
Language
en
Open access
Locations
  • Translational Neuroscience (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (Z99 MH999999)
  • National Institute of Mental Health
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords
suicide, suicide attempts, bipolar disorder, neurobiology of suicide, neurochemistry, epigenetics, endophenotypes, suicide risk factors, aggression, impulsivity, suicide prevention, molecular targets

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