In vivo glucose sensing for diabetes management: progress towards non-invasive monitoring
Open accessAbstract
A device for continuous in vivo monitoring of glucose concentration in people with diabetes has been a clinical and research priority for many years but now has an urgency which is probably unquestioned in diabetes care. The purpose of this article is to explain recent advances in technology that are bringing glucose sensors closer to routine use and to highlight some of the remaining problems. Important new technologies include artificial receptors for glucose, tissue fluid sampling techniques, and new approaches to non-invasive sensing, such as fluorescence lifetime measurements.
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Near-infrared spectroscopy allows 90-95% of light to pass through the stratum corneum and epidermis into subcutaneous space with minimal tissue adsorption independent of skin pigmentation.
“Optical detection of glucose via near infrared (NIR) spectroscopy enables 90–95% of the light to pass through the human stratum corneum and epidermis into subcutaneous space with minimal tissue adsorption independent of skin pigmentation.19,40–41”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [40]
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- Authors
- Pickup, J., McCartney, L., Rolinski, O., & Birch, D.
- Affiliations
- Guy's Hospital (GB)
- University of Strathclyde (GB)
- Corresponding author
- Pickup, J.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1999-11-13
- Volume
- 319
- Issue
- 7220
- Pages
- 1289-1289
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC1129067
- OpenAlex
- W2055123658
- Cited by
- 66
- References
- 48
- Citations by year
- 2026: 1 · 2024: 1 · 2018: 1 · 2016: 1 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Strathprints: The University of Strathclyde institutional repository (University of Strathclyde) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Keywords
- glucose detection, diabetes management, continuous glucose monitoring, non-invasive monitoring, fluorescence lifetime measurement
- MeSH terms
- Diabetes Mellitus, Type 1, Humans, Blood Glucose Self-Monitoring, Biosensing Techniques
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