. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty.
Abstract
BACKGROUND: Older healthy and HIV-infected adults exhibit physiological similarities. Frailty is a clinical syndrome associated with aging that identifies a subset of older adults at high risk of mortality and other outcomes. We investigated whether HIV infection increases the prevalence of a frailty-related phenotype (FRP) that approximates a clinical definition of frailty. METHODS: We first defined the FRP and assessed its prevalence among HIV-uninfected men followed in the Multicenter AIDS Cohort Study (MACS) between 1994 and 2004. Using repeated measurements logistic regression models, we then assessed the association between FRP and HIV infection before the era of highly active antiretroviral therapies, adjusting for covariates among HIV-uninfected (N = 1905) and incident HIV cases (N = 245). RESULTS: HIV infection was strongly associated with FRP prevalence. Compared to HIV-uninfected men of similar age, ethnicity and education, HIV-infected men were more likely to have the FRP for all durations of infection: for < or =4 years, the adjusted odds ratio (OR) was 3.38, with 95% confidence interval (CI), 1.25-9.11, and for 4.01-8 years and 8.01-12 years the corresponding figures were (OR = 12.95, 95% CI, 6.60-25.40) and (OR = 14.68, 95% CI, 7.60-28.35), respectively. The FRP prevalence for 55-year-old men infected with HIV for < or =4 years (3.4%; 95% CI, 1.3-8.6) was similar to that of uninfected men > or =65 years old (3.4%; 95% CI, 1.5-7.6). CONCLUSION: In this cohort, HIV infection was associated with an earlier occurrence of a phenotype that resembles the phenotype of frailty in older adults without HIV infection. Studies of frailty in the setting of HIV infection may help to clarify the biological mechanism of frailty.
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Few middle aged individuals with HIV infection demonstrate the full frailty phenotype.
“While few middle aged individuals with HIV infection demonstrate the full frailty phenotype (66), there is a concern that those with HIV infection may have significantly decreased physiologic reserve at younger ages than those without HIV infection.”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [66]
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- Authors
- Desquilbet, L., Jacobson, L. P., Fried, L. P., Phair, J. P., Jamieson, B. D., Holloway, M., Margolick, J. B., & Study, F. T. M. A. C.
- Affiliations
- Johns Hopkins University (US)
- Northwestern University (US)
- University of California, Los Angeles (US)
- University of Pittsburgh (US)
- Corresponding author
- Desquilbet, L.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-11-01
- Volume
- 62
- Issue
- 11
- Pages
- 1279-1286
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2145677576
- Cited by
- 420
- References
- 75
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 19 · 2023: 25 · 2022: 33 · 2021: 27 · 2020: 16 · 2019: 30 · 2018: 32 · 2017: 20 · 2016: 31 · 2015: 19 · 2014: 25 · 2013: 36 · 2012: 25
- FWCI
- 11.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Northwestern University
- Johns Hopkins University
- University of Pittsburgh
- Deutsches Krebsforschungszentrum
- University of California, Los Angeles
- Johns Hopkins Bloomberg School of Public Health
- National Cancer Institute (UO1-AI-35039, UO1 AI35040, UO1-AI-35042, UO1 AI35041, UO1 AI35043, UO1-AI-37984, UO1-AI-37613, 5-MO1-RR-00722)
- National Institute of Allergy and Infectious Diseases (UO1-AI 35043, U01 AI 35039, UO1 AI37613, U01 AI 37613, U01-AI-35040, U01-AI-37984, UO1-AI35040, UO1‐AI‐35041, U01AI35042, U01AI035040, U01AI037984, UO1-AI35039, U01AI035041, U01AI035043, U01-AI-35041, UO1 AI37984, 5-MO1-RR-00722, U01AI037613, U01AI035039, UO1-AI35042, U01 AI-35043, U01AI035042)
- National Center for Research Resources (5M01 RR 00722, M01RR000722)
- Topics
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- HIV-1 infection, frailty, aging, older men, Multicenter AIDS Cohort Study, HIV incidence, mortality risk, antiretroviral therapy era
- MeSH terms
- Adult, Aged, Humans, Male, Middle Aged, Phenotype, HIV-1, HIV Infections, Prevalence, Frail Elderly
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