Cancer expert doubts claims about prostate cancer trial
Abstract
A leading clinical oncologist has raised questions about claims that a new drug could treat as many as 80% of men diagnosed as having the most aggressive and previously drug resistant form of prostate cancer. The results of the phase I clinical trial by the Institute of Cancer Research and the Royal Marsden Hospital, showed significant tumour shrinkage and big falls in prostate specific antigen (PSA) concentrations in most of the 21 men with advanced prostate cancer who received the drug abiraterone acetate ( Journal of Clinical Oncology 2008 Jul 21; doi: 10.1200/JCO.2007.15.9749). But Nick James, professor of clinical oncology at Birmingham University, said that it was far …
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Implementation strategies are inherently complex social interventions, as they address multifaceted and complicated processes within interpersonal, organizational, and community contexts.
“Implementation strategies are inherently complex social interventions, as they address multifaceted and complicated processes within interpersonal, organizational, and community contexts [12,56-58].”
From Implementation strategies: recommendations for specifying and reporting (2013) · cites this paper as [56]
Important frameworks for intervention design and evaluation stress that theory should inform design and that interventions should be specified by component techniques.
“Key frameworks for designing and evaluating behaviour change interventions (Collins et al., 2011;Craig et al., 2008) emphasise the importance of using theory to inform intervention design as well as specifying interventions in terms of component BCTs.”
From Theories and techniques of behaviour change: Developing a cumulative science of behaviour change (2012) · cites this paper as Craig et al., 2008
Behaviour change interventions are typically complex and consist of multiple interacting components.
“Behaviour change interventions are usually complex, comprising many interacting components (Craig et al., 2008).”
From Theories and techniques of behaviour change: Developing a cumulative science of behaviour change (2012) · cites this paper as Craig et al., 2008
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MacMillan, F., Fitzsimons, C. F., Black, K., Granat, M. H., Grant, M., Grealy, M., Macdonald, H., McConnachie, A., Rowe, D. A., Shaw, R., et al. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-120 · Cited by 28 · see citing works
Repetitive arm functional tasks after stroke (RAFTAS): a pilot randomised controlled trial
Brkic, L., Shaw, L. C., van Wijck, F., Francis, R. P., Price, C., Förster, A., Langhorne, P., Watkins, C. L., & Rodgers, H. (2016) · Pilot and Feasibility Studies · doi:10.1186/s40814-016-0088-5 · Cited by 28 · see citing works
- Authors
- Cole, A.
- Corresponding author
- Cole, A.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2008-07-24
- Volume
- 337
- Issue
- jul24 3
- Pages
- a979-a979
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2005294651
- Cited by
- 255
- References
- 0
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 9 · 2022: 12 · 2021: 19 · 2020: 12 · 2019: 6 · 2018: 14 · 2017: 17 · 2016: 23 · 2015: 19 · 2014: 20 · 2013: 33 · 2012: 20
- Type
- other
- Language
- en
- Open access
- closed
- Locations
- BMJ (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Keywords
- abiraterone, prostate cancer, advanced prostate cancer, drug resistance, prostate-specific antigen, tumor shrinkage
- MeSH terms
- Androstenes, Androstenols, Antineoplastic Agents, Humans, Male, Prostatic Neoplasms, Clinical Trials, Phase I as Topic
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