Cited by 189Cognitive Abilities and TestingHealth disparities and outcomesGenetic Associations and Epidemiology

Childhood intelligence in relation to major causes of death in 68 year follow-up: prospective population study

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Calvin, Catherine M, Batty, G David, Der, Geoff, Brett, Caroline E, Taylor, Adele, Pattie, Alison, Čukić, Iva, Deary, Ian J·2017·BMJ

Abstract

Objectives To examine the association between intelligence measured in childhood and leading causes of death in men and women over the life course. Design Prospective cohort study based on a whole population of participants born in Scotland in 1936 and linked to mortality data across 68 years of follow-up. Setting Scotland. Participants 33 536 men and 32 229 women who were participants in the Scottish Mental Survey of 1947 (SMS1947) and who could be linked to cause of death data up to December 2015. Main outcome measures Cause specific mortality, including from coronary heart disease, stroke, specific cancer types, respiratory disease, digestive disease, external causes, and dementia. Results Childhood intelligence was inversely associated with all major causes of death. The age and sex adjusted hazard ratios (and 95% confidence intervals) per 1 SD (about 15 points) advantage in intelligence test score were strongest for respiratory disease (0.72, 0.70 to 0.74), coronary heart disease (0.75, 0.73 to 0.77), and stroke (0.76, 0.73 to 0.79). Other notable associations (all P<0.001) were observed for deaths from injury (0.81, 0.75 to 0.86), smoking related cancers (0.82, 0.80 to 0.84), digestive disease (0.82, 0.79 to 0.86), and dementia (0.84, 0.78 to 0.90). Weak associations were apparent for suicide (0.87, 0.74 to 1.02) and deaths from cancer not related to smoking (0.96, 0.93 to 1.00), and their confidence intervals included unity. There was a suggestion that childhood intelligence was somewhat more strongly related to coronary heart disease, smoking related cancers, respiratory disease, and dementia in women than men (P value for interactions <0.001, 0.02, <0.001, and 0.02, respectively).Childhood intelligence was related to selected cancer presentations, including lung (0.75, 0.72 to 0.77), stomach (0.77, 0.69 to 0.85), bladder (0.81, 0.71 to 0.91), oesophageal (0.85, 0.78 to 0.94), liver (0.85, 0.74 to 0.97), colorectal (0.89, 0.83 to 0.95), and haematopoietic (0.91, 0.83 to 0.98). Sensitivity analyses on a representative subsample of the cohort observed only small attenuation of the estimated effect of intelligence (by 10-26%) after adjustment for potential confounders, including three indicators of childhood socioeconomic status. In a replication sample from Scotland, in a similar birth year cohort and follow-up period, smoking and adult socioeconomic status partially attenuated (by 16-58%) the association of intelligence with outcome rates. Conclusions In a whole national population year of birth cohort followed over the life course from age 11 to age 79, higher scores on a well validated childhood intelligence test were associated with lower risk of mortality ascribed to coronary heart disease and stroke, cancers related to smoking (particularly lung and stomach), respiratory diseases, digestive diseases, injury, and dementia.

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  • There is strong evidence from industrial and organizational psychology and cognitive epidemiology studies that IQ is associated with occupational, health, and other outcomes.

    “There is strong evidence from industrial and organizational psychology and cognitive epidemiology studies that IQ is associated with occupational, health, and other outcomes (e.g., Calvin et al., 2017)”

    From How Much Does Education Improve Intelligence? A Meta-Analysis (2018) · cites this paper as Calvin et al., 2017

    The Discussion reports associations between childhood intelligence and multiple causes of death, supporting the health-outcomes portion of the claim. It also mentions occupational status as a possible mediator, but does not establish an association between IQ and occupational outcomes or provide industrial and organizational psychology evidence. The indexed passages have no page numbers. (LLM, conf=0.87)

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  1. [2]Čukić I, Brett CE, Calvin CM, Batty GD, Deary IJ. Childhood IQ is associated with all-cause mortality in a full year-of-birth cohort: 68-year follow-up of 66 616 members of the Scottish Mental Survey 1947. Intelligence 2017; 63: 45- 50. 28713184 PMC5491698
  2. [32]Deary IJ, Whiteman MC, Starr JM, Whalley LJ, Fox HC. The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947. J Pers Soc Psychol 2004; 86: 130- 47. 10.1037/0022-3514.86.1.130 pmid:14717632. 14717632 · DOI · Paper page

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Authors
Calvin, C. M., Batty, G. D., Der, G., Brett, C. E., Taylor, A., Pattie, A., Čukić, I., & Deary, I. J.
Affiliations
  • Warneford Hospital (GB)
  • University College London (GB)
  • MRC/CSO Social and Public Health Sciences Unit (GB)
  • Liverpool John Moores University (GB)
  • University of Edinburgh (GB)
Corresponding author
  • Calvin, Catherine M
  • Deary, Ian J
Venue
BMJ
Publisher
BMJ
Published
2017-06-28
Volume
357
Pages
j2708
ISSN
  • 1756-1833 (ISSN-L)
  • 0959-8138
OpenAlex
W2620649070
Cited by
189
References
79
Citations by year
2026: 10 · 2025: 27 · 2024: 20 · 2023: 29 · 2022: 17 · 2021: 21 · 2020: 15 · 2019: 22 · 2018: 23 · 2017: 5
FWCI
23.15
Type
journal article
Language
en
Open access
Locations
  • BMJ (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Liverpool John Moores University (acceptedVersion, cc-by)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
Funders
  • Medical Research Charities Group
  • University of Edinburgh (MR/K026992/1)
  • Centre for Cognitive Ageing and Cognitive Epidemiology (MR/K026992/1)
  • Dementias Platform UK (MR/L023784/2)
  • Directorate for Biological Sciences
  • Medical Research Council (MR/L023784/2, MR/K026992/1, MR/M013111/1, MR/L023784/1)
  • Biotechnology and Biological Sciences Research Council (MR/K026992/1)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Social Sciences › Health › Health disparities and outcomes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
child intelligence, intelligence test scores, mortality, cause-specific mortality, coronary artery disease, stroke, respiratory diseases, cancer, dementia, suicide, sex differences, life course, birth cohort, tobacco-related cancer, lung cancer, gastric cancer, bladder cancer, sex differences in mortality, educational disadvantage
MeSH terms
Adolescent, Adult, Aged, Cause of Death, Child, Female, Follow-Up Studies, Health Surveys, Humans, Intelligence, Longevity, Male, Middle Aged, Psychosocial Deprivation, Scotland, Socioeconomic Factors, Survival Analysis, Risk Assessment

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