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A guide to systematic review and meta-analysis of prognostic factor studies
Open accessAbstract
Prognostic factors are associated with the risk of future health outcomes in individuals with a particular health condition or some clinical start point (eg, a particular diagnosis). Research to identify genuine prognostic factors is important because these factors can help improve risk stratification, treatment, and lifestyle decisions, and the design of randomised trials. Although thousands of prognostic factor studies are published each year, often they are of variable quality and the findings are inconsistent. Systematic reviews and meta-analyses are therefore needed that summarise the evidence about the prognostic value of particular factors. In this article, the key steps involved in this review process are described.
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Self-citationMeta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions
Sterne, J. A., Hernán, M. A., Reeves, B. C., Savović, J., Berkman, N. D., Viswanathan, M., Henry, D., Altman, D. G., Ansari, M. T., Boutron, I., et al. (2016) · BMJ · doi:10.1136/bmj.i4919 · Cited by 20,329
Self-citationBorenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2021) · doi:10.1002/9781119558378 · Cited by 9,799
Sterne, J. A. C., Sutton, A. J., Ioannidis, J. P. A., Terrin, N., Jones, D. R., Lau, J., Carpenter, J., Rucker, G., Harbord, R. M., Schmid, C. H., et al. (2011) · BMJ · doi:10.1136/bmj.d4002 · Cited by 7,709
Self-citationPearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401
Moons, K. G. M., Altman, D. G., Reitsma, J. B., Ioannidis, J. P. A., Macaskill, P., Steyerberg, E. W., Vickers, A. J., Ransohoff, D. F., & Collins, G. S. (2015) · Annals of Internal Medicine · doi:10.7326/m14-0698 · Cited by 5,147
Self-citationAssessing Bias in Studies of Prognostic Factors
Hayden, J. A., van der Windt, D. A., Cartwright, J. L., Côté, P., & Bombardier, C. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-158-4-201302190-00009 · Cited by 3,287
Self-citationInterpretation of random effects meta-analyses
Riley, R. D., Higgins, J. P. T., & Deeks, J. J. (2011) · BMJ · doi:10.1136/bmj.d549 · Cited by 2,884
Self-citationA Re-Evaluation of Random-Effects Meta-Analysis
Higgins, J. P. T., Thompson, S. G., & Spiegelhalter, D. J. (2009) · Journal of the Royal Statistical Society Series A: Statistics in Society · doi:10.1111/j.1467-985x.2008.00552.x · Cited by 2,569
Methods for Trend Estimation from Summarized Dose-Response Data, with Applications to Meta-Analysis
Greenland, S., & Longnecker, M. P. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116237 · Cited by 2,353
Moons, K. G. M., de Groot, J. A. H., Bouwmeester, W., Vergouwe, Y., Mallett, S., Altman, D. G., Reitsma, J. B., & Collins, G. S. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001744 · Cited by 2,018
Self-citationMeta-analysis of individual participant data: rationale, conduct, and reporting
Riley, R. D., Lambert, P. C., & Abo-Zaid, G. (2010) · BMJ · doi:10.1136/bmj.c221 · Cited by 1,701
Self-citationPrognosis Research Strategy (PROGRESS) 3: Prognostic Model Research
Steyerberg, E. W., Moons, K. G. M., van der Windt, D. A., Hayden, J. A., Perel, P., Schroter, S., Riley, R. D., Hemingway, H., Altman, D. G., & for the PROGRESS Group (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001381 · Cited by 1,508
Self-citationREporting recommendations for tumour MARKer prognostic studies (REMARK).
for the Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics, McShane, L. M., Altman, D. G., Sauerbrei, W., Taube, S. E., Gion, M., & Clark, G. M. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602678 · Cited by 1,394
Self-citationEgger, M., Jüni, P., Bartlett, C., Holenstein, F., & Sterne, J. (2003) · Health Technology Assessment · doi:10.3310/hta7010 · Cited by 1,181
Vickers, A. J., Van Calster, B., & Steyerberg, E. W. (2016) · BMJ · doi:10.1136/bmj.i6 · Cited by 1,163
Prognosis Research Strategy (PROGRESS) 2: Prognostic Factor Research
Riley, R. D., Hayden, J. A., Steyerberg, E. W., Moons, K. G. M., Abrams, K., Kyzas, P. A., Malats, N., Briggs, A., Schroter, S., Altman, D. G., et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001380 · Cited by 823
Self-citationA refined method for the meta-analysis of controlled clinical trials with binary outcome
Hartung, J., & Knapp, G. (2001) · Statistics in Medicine · doi:10.1002/sim.1009 · Cited by 775
Collins, G. S., de Groot, J. A., Dutton, S., Omar, O., Shanyinde, M., Tajar, A., Voysey, M., Wharton, R., Yu, L.-M., Moons, K. G., et al. (2014) · BMC Medical Research Methodology · doi:10.1186/1471-2288-14-40 · Cited by 729
Self-citationA guide to systematic review and meta-analysis of prediction model performance
Debray, T. P. A., Damen, J. A. A. G., Snell, K. I. E., Ensor, J., Hooft, L., Reitsma, J. B., Riley, R. D., & Moons, K. G. M. (2017) · BMJ · doi:10.1136/bmj.i6460 · Cited by 657
Self-citationReporting and Methods in Clinical Prediction Research: A Systematic Review
Bouwmeester, W., Zuithoff, N. P. A., Mallett, S., Geerlings, M. I., Vergouwe, Y., Steyerberg, E. W., Altman, D. G., & Moons, K. G. M. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001221 · Cited by 600
Self-citationHuguet, A., Hayden, J. A., Stinson, J., McGrath, P. J., Chambers, C. T., Tougas, M. E., & Wozney, L. (2013) · Systematic Reviews · doi:10.1186/2046-4053-2-71 · Cited by 531
Self-citationCollins, G. S., Mallett, S., Omar, O., & Yu, L.-M. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-103 · Cited by 484
Random-Effects Meta-analysis of Inconsistent Effects: A Time for Change
Cornell, J. E., Mulrow, C. D., Localio, R., Stack, C. B., Meibohm, A. R., Guallar, E., & Goodman, S. N. (2014) · Annals of Internal Medicine · doi:10.7326/m13-2886 · Cited by 453
A new measure of prognostic separation in survival data
Royston, P., & Sauerbrei, W. (2004) · Statistics in Medicine · doi:10.1002/sim.1621 · Cited by 450
Geersing, G.-J., Bouwmeester, W., Zuithoff, P., Spijker, R., Leeflang, M., & Moons, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032844 · Cited by 350
Self-citationPartlett, C., & Riley, R. D. (2017) · Statistics in Medicine · doi:10.1002/sim.7140 · Cited by 240
Self-citationBurton, A., & Altman, D. G. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601907 · Cited by 219
Debray, T. P. A., Moons, K. G. M., & Riley, R. D. (2018) · Research Synthesis Methods · doi:10.1002/jrsm.1266 · Cited by 212
Self-citationReporting methods in studies developing prognostic models in cancer: a review
Mallett, S., Royston, P., Dutton, S., Waters, R., & Altman, D. G. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-20 · Cited by 206
Self-citationReporting performance of prognostic models in cancer: a review.
Mallett, S., Royston, P., Waters, R., Dutton, S., & Altman, D. G. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-21 · Cited by 195
Empirical evidence of the importance of comparative studies of diagnostic test accuracy
Takwoingi, Y., Leeflang, M. M. G., & Deeks, J. J. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-158-7-201304020-00006 · Cited by 187
Research works printed but not linked: 46
- 10.7326/0003-4819-149-12-200812160-00008 · DOI · Paper page
- 10.1136/bmj.e5595 · DOI · Paper page
- 10.1136/bmj.e5793 · DOI · Paper page
- 10.1136/bmj.323.7306.224 · DOI · Paper page
- 10.1038/ncponc0287 · DOI
- 10.1038/sj.bjc.6604999 · DOI
- 10.3310/hta7050 · DOI · Paper page
- 10.1371/journal.pmed.1000286 · DOI
- Royston, 2006, Explained variation for survival models, Stata J, 6, 83, 10.1177/1536867X0600600105 · DOI · Paper page
- 10.1002/sim.2929 · DOI · Paper page
- 10.1093/aje/kwt298 · DOI
- 10.1002/sim.7653 · DOI
- 10.1136/jamia.2001.0080391 · DOI · Paper page
- 10.1136/bmj.38446.498542.8F · DOI · Paper page
- Wong, 2003, Developing optimal search strategies for detecting sound clinical prediction studies in MEDLINE, AMIA Annu Symp Proc, 728
- 10.1002/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8 · DOI
- 10.1186/1745-6215-8-16 · DOI · Paper page
- 10.1016/j.cct.2008.06.002 · DOI
- 10.1016/j.jclinepi.2017.12.017 · DOI
- 10.1038/sj.bjc.6600886 · DOI
- 10.1002/9780470743386.ch7 · DOI · Paper page
- 10.1002/jrsm.1201 · DOI
- Nieminen, 2013, Standardised regression coefficient as an effect size index in summarising the reported findings between quantitative exposure and response variables in epidemiological studies, Epidemiol Biostatistics Public Health, 10, e8854
- 10.1016/j.ejca.2007.08.030 · DOI
- 10.1093/jnci/djk032 · DOI
- 10.1093/jnci/dji184 · DOI
- 10.1016/j.jclinepi.2012.06.020 · DOI · Paper page
- 10.1371/journal.pmed.1001216 · DOI · Paper page
- 10.1002/jrsm.1140 · DOI
- 10.1097/00001648-199305000-00005 · DOI · Paper page
- 10.1093/aje/kwj141 · DOI · Paper page
- 10.1002/sim.1595 · DOI
- 10.1093/aje/kwr265 · DOI · Paper page
- 10.1002/sim.6493 · DOI
- 10.1002/sim.3540 · DOI
- 10.1136/bmj.j3932 · DOI
- 10.1186/1471-2288-8-79 · DOI · Paper page
- 10.1002/sim.4780140406 · DOI · Paper page
- 10.1001/jama.295.6.676 · DOI · Paper page
- 10.1093/biomet/80.1.27 · DOI · Paper page
- 10.1136/bmj.h870 · DOI · Paper page
- 10.1080/03610920600629666 · DOI
- 10.1371/journal.pmed.1001671 · DOI
- Moons, 2018, Implementing systematic reviews of prognosis studies in Cochrane, Cochrane Database Syst Rev, 10, ED000129
- Altman, 2006, Advances in statistical methods for the health sciences., 3
- 10.1186/1471-2288-12-56 · DOI
Cited by
Calculating the sample size required for developing a clinical prediction model
Riley, R. D., Ensor, J., Snell, K. I. E., Harrell, F. E., Martin, G. P., Reitsma, J. B., Moons, K. G. M., Collins, G., & van Smeden, M. (2020) · BMJ · doi:10.1136/bmj.m441 · Cited by 2,917
Barker, T. H., Migliavaca, C. B., Stein, C., Colpani, V., Falavigna, M., Aromataris, E., & Munn, Z. (2021) · BMC Medical Research Methodology · doi:10.1186/s12874-021-01381-z · Cited by 738
Application of standardized regression coefficient in meta-analysis
Nieminen, P. (2022) · BioMedInformatics · doi:10.3390/biomedinformatics2030028 · Cited by 230
Notarte, K. I., de Oliveira, M. H. S., Peligro, P. J., Velasco, J. V., Macaranas, I., Ver, A. T., Pangilinan, F. C., Pastrana, A., Goldrich, N., Kavteladze, D., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11247314 · Cited by 209
Cai, Y., Cai, Y.-Q., Tang, L.-Y., Wang, Y.-H., Gong, M., Jing, T.-C., Li, H.-J., Li-Ling, J., Hu, W., Yin, Z., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03273-7 · Cited by 122
Metadata
- Authors
- Riley, R. D., Moons, K. G. M., Snell, K. I. E., Ensor, J., Hooft, L., Altman, D. G., Hayden, J., Collins, G. S., & Debray, T. P. A.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2019-01-30
- Volume
- 364
- Pages
- k4597
- ISSN
- 1756-1833 (ISSN-L)
- 0959-8138
- OpenAlex
- W2914356810
- Cited by
- 742
- References
- 34
- FWCI
- 14.81
- Type
- journal article
- Language
- en
- Open access
- green
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
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