The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Glioblastoma: clinical presentation, diagnosis, and management
Open accessAbstract
What you need to know Early symptoms of brain tumours in adults are non-specific, and patients may present multiple times to primary care services before they are referred for investigation. Look for symptoms of raised intracranial pressure (such as headaches exacerbated by lying down, triggered by the Valsalva manoeuvre, or associated with vomiting or visual disturbance), combinations of symptoms (such as headache plus cognitive impairment, headache plus weakness, headache plus personality change), and symptoms that progress over time. New onset focal or generalised seizures in adulthood also warrant investigation for a brain tumour. In patients with symptoms or signs suggestive of a brain tumour, arrange urgent magnetic resonance imaging of the head with and without contrast through a rapid access “suspected cancer” pathway, when available. In patients with suspicion of raised intracranial pressure, arrange a same day clinical assessment and contrast enhanced computed tomography of the head. Glioblastoma is the most common primary brain cancer. Standard treatment includes maximal safe resection followed by concomitant radiotherapy and temozolomide chemotherapy and then adjuvant temozolomide. Disease progression is expected in all cases and consideration of further treatment should take into account the patient’s performance status, tumour size, tumour location, and time since first treatment. Key supportive medications may include corticosteroids for vasogenic oedema and antiepileptic medication if seizures occur. Because of the incurable and rapidly progressive nature of glioblastoma, close collaboration between multidisciplinary teams in tertiary care hospitals and primary care services is recommended. Early involvement of general practitioners and specialist community palliative care teams can assist patients and caregivers with advance care planning as well as management of symptoms, physical and cognitive impairment, communication difficulties, and the innate uncertainties about disease progression.
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Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Stupp, R., Mason, W. P., van den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J. B., Belanger, K., Brandes, A. A., Marosi, C., Bogdahn, U., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043330 · Cited by 21,807
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
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IDH1 and IDH2 Mutations in Gliomas
Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847
The epidemiology of glioma in adults: a "state of the science" review
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Ostrom, Q. T., Gittleman, H., Truitt, G., Boscia, A., Kruchko, C., & Barnholtz-Sloan, J. S. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy131 · Cited by 2,138
EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood
Weller, M., van den Bent, M., Preusser, M., Le Rhun, E., Tonn, J. C., Minniti, G., Bendszus, M., Balana, C., Chinot, O., Dirven, L., et al. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00447-z · Cited by 2,048
Management of glioblastoma: State of the art and future directions
Tan, A. C., Ashley, D. M., López, G. Y., Malinzak, M., Friedman, H. S., & Khasraw, M. (2020) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21613 · Cited by 1,972
Epidemiologic and Molecular Prognostic Review of Glioblastoma
Thakkar, J. P., Dolecek, T. A., Horbinski, C., Ostrom, Q. T., Lightner, D. D., Barnholtz-Sloan, J. S., & Villano, J. L. (2014) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-0275 · Cited by 1,390
Cited by
Unraveling the impact of miR-21 on apoptosis regulation in glioblastoma
Shaikh, M. A. J., Altamimi, A. S. A., Afzal, M., Gupta, G., Singla, N., Gilhotra, R., almalki, W. H., Kazmi, I., Alzarea, S. I., Prasher, P., et al. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155121 · Cited by 37
MiR-128-3p – a gray eminence of the human central nervous system
Kiel, K., Król, S. K., Bronisz, A., & Godlewski, J. (2024) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2024.102141 · Cited by 15
Advances of MR imaging in glioma: What the neurosurgeon needs to know
Falk Delgado, A. (2025) · Acta Neurochirurgica · doi:10.1007/s00701-025-06593-6 · Cited by 14
Metadata
- Authors
- McKinnon, C., Nandhabalan, M., Murray, S. A., & Plaha, P.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2021-07-14
- Volume
- 374
- Pages
- n1560
- ISSN
- 1756-1833 (ISSN-L)
- OpenAlex
- W3178127564
- Cited by
- 391
- References
- 55
- FWCI
- 28.06
- Type
- journal article
- Language
- en
- Open access
- green
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