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Cited by 33Clinical Nutrition and GastroenterologyChronic Obstructive Pulmonary Disease (COPD) ResearchNutrition and Health in Aging

Oral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trial

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Ingadottir, Arora Ros, Beck, Anne Marie, Baldwin, Christine, Weekes, Christine Elizabeth, Geirsdottir, Olof Gudny, Ramel, Alfons, Gislason, Thorarinn, Gunnarsdottir, Ingibjorg·2019·BMJ Open Respiratory Research
DOI 10.1136/bmjresp-2018-000349PMC PMC6326325
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Abstract

Introduction: Intervention studies have mainly used oral nutritional supplements (ONS) for the management of patients with chronic obstructive pulmonary disease (COPD) identified as at nutritional risk. In this 12-month randomised feasibility trial, we assessed the (1) feasibility of the recruitment, retention and provision of two interventions: ONS and between-meal snacks (snacks) and (2) the potential impact of the provision of snacks and ONS on body weight and quality of life in patients with COPD. Methods: Hospitalised patients with COPD, at nutritional risk, were randomised to ONS (n=19) or snacks (n=15) providing 600 kcal and 22 g protein a day in addition to regular daily diet. The intervention started in hospital and was continued for 12 months after discharge from the hospital. Results: Study recruitment rate was n=34 (45%) and retention rate at 12 months was similar for both groups: n=13 (68%) in the ONS group and n=10 (67%) in the Snacks group. Both groups gained weight from baseline to 12 months (2.3±4.6 kg (p=0.060) in the ONS group and 4.4±6.4 kg (p=0.030) in the Snacks group). The St George’s Respiratory Questionnaire total score improved from baseline to 12 months in both groups (score 3.9±11.0 (p=0.176) in the ONS group and score 8.9±14.1 (p=0.041) in the Snacks group). Discussion: In patients with COPD who are at nutritional risk snacks are at least as feasible and effective as ONS, however, adequately powered trials that take account of the difficulties in recruiting this patient group are required to confirm this effect.

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  • Correa-Arruda et al. showed that muscular function was impaired after overnight fasting of adult patients hospitalized for medical treatment, especially for those with low ingestion, malnourished and elderly.

    “Correa-Arruda et al. showed the impact of overnight fasting on muscular function. The 614 muscular function was impaired after overnight fasting of adult patients hospitalized for 615 medical treatment, especially for those with low ingestion, malnourished and elderly [48].”

    From ESPEN guideline on hospital nutrition (2021) · cites this paper as [48]

    The Methods (Outcomes) and Results (Energy and protein intake) describe a COPD nutrition trial that measured functional performance and muscle strength over time; the Results say these measures remained stable from baseline to 12 months. Searches for overnight fasting and Correa-Arruda found no passage addressing whether fasting impaired muscle function in hospitalized adults or the specified subgroups. Page numbers were not available in our copy. (LLM, conf=0.76)

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Cited by

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Authors
Ingadottir, A. R., Beck, A. M., Baldwin, C., Weekes, C. E., Geirsdottir, O. G., Ramel, A., Gislason, T., & Gunnarsdottir, I.
Affiliations
  • Unit for Nutrition Research, Landspitali University Hospital and Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland
  • University of Copenhagen (DK)
  • King's College London (GB)
  • University of Iceland (IS)
  • Faculty of Medicine, University of Iceland, Reykjavik, Iceland
ORCID
Venue
BMJ Open Respiratory Research
Publisher
BMJ
Published
2019-01
Volume
6
Issue
1
Pages
e000349
ISSN
2052-4439 (ISSN-L)
DOI
10.1136/bmjresp-2018-000349
PMC
PMC6326325
OpenAlex
W2907327259
Cited by
33
References
5
Citations by year
2026: 3 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 1 · 2019: 3
FWCI
2.47
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • BMJ Open Respiratory Research (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Hirsla (Landspítali University Hospital) (submittedVersion, other-oa)
Funders
  • Eimskip University Fund (HI17040070)
  • MS Iceland Dairies
  • Nutricia
  • Icelandic Research Fund of the Icelandic Centre for Research (141216-051)
  • Landspitali University Hospital Research Fund
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
chronic obstructive pulmonary disease, nutritional risk, oral nutritional supplements, nutritional therapy, weight gain, quality of life, St George's Respiratory Questionnaire, hospitalized patients, post-discharge follow-up, trial feasibility
MeSH terms
Aged, Aged, 80 and over, Body Weight, Energy Intake, Feasibility Studies, Female, Humans, Male, Middle Aged, Nutritional Status, Quality of Life, Treatment Outcome, Dietary Supplements, Pulmonary Disease, Chronic Obstructive, Malnutrition, Nutrition Therapy, Snacks

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