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Cited by 590Infant Nutrition and HealthProbiotics and Fermented FoodsNeonatal and Maternal Infections

Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Neonates

Bin-Nun, Alona, Bromiker, Ruben, Wilschanski, Michael, Kaplan, Michael, Rudensky, Bernard, Caplan, Michael, Hammerman, Cathy·2005·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2005.03.054
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Abstract

Objective To test the hypothesis that normalizing the intestinal flora by administration of prophylactic probiotics would provide a natural defense, thereby reducing both the incidence and severity of necrotizing enterocolitis (NEC) in preterm neonates. Study design Neonates < or =1500 g birth weight were randomized to either receive a daily feeding supplementation with a probiotic mixture (Bifidobacteria infantis, Streptococcus thermophilus, and Bifidobacteria bifidus; Solgar, Israel) of 10(9) colony forming units (CFU)/day or to not receive feed supplements. NEC was graded according to Bell's criteria. Results For 72 study and 73 control infants, respectively, birth weight (1152 +/- 262 g vs 1111 +/- 278 g), gestational age (30 +/- 3 weeks vs 29 +/- 4 weeks), and time to reach full feeds (14.6 +/- 8.7 days vs 17.5 +/- 13.6 days) were not different. The incidence of NEC was reduced in the study group (4% vs 16.4%; P=.03). NEC was less severe in the probiotic-supplemented infants (Bell's criteria 2.3 +/- 0.5 vs 1.3 +/- 0.5; P=.005). Three of 15 babies who developed NEC died, and all NEC-related deaths occurred in control infants. Conclusion Probiotic supplementation reduced both the incidence and severity of NEC in our premature neonatal population.

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Crossref · 10.1016/j.jpeds.2005.03.054

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  • Different bifidobacteria species, mostly combined with St. thermophilus and/or Lb. acidophilus, have been shown to be effective in the prevention of necrotizing enterocolitis in children.

    “as well as in the prevention of necrotizing enterocolitis in children [138,145,146]”

    From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [146]

  • Randomised controlled trials support a protective role of probiotics against necrotising enterocolitis.

    “randomised controlled trials support a protective role of probiotics.162,163”

    From The microbiome and critical illness (2016) · cites this paper as [162]

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Authors
Bin-Nun, A., Bromiker, R., Wilschanski, M., Kaplan, M., Rudensky, B., Caplan, M., & Hammerman, C.
Affiliations
Ben-Gurion University of the Negev (IL)
Corresponding author
Hammerman, Cathy
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2005-08
Volume
147
Issue
2
Pages
192-196
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2005.03.054
OpenAlex
W2100119754
Cited by
590
References
28
Citations by year
2026: 7 · 2025: 6 · 2024: 14 · 2023: 20 · 2022: 8 · 2021: 16 · 2020: 11 · 2019: 18 · 2018: 12 · 2017: 24 · 2016: 60 · 2015: 36 · 2014: 34 · 2013: 41 · 2012: 45
FWCI
33.33
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords
necrotizing enterocolitis, probiotics, very low birth weight infants, preterm infants, Bifidobacterium infantis, Streptococcus thermophilus, Bifidobacterium bifidum, probiotic supplementation, gut microbiota, NEC incidence, NEC severity, NEC mortality
MeSH terms
Administration, Oral, Apgar Score, Bifidobacterium, Female, Gestational Age, Humans, Infant, Newborn, Male, Severity of Illness Index, Infant, Very Low Birth Weight, Probiotics, Enterocolitis, Necrotizing, Streptococcus thermophilus

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