Randomized placebo‐controlled trial assessing the effect of bifidobacteria‐fermented milk on active ulcerative colitis

Kato, K.; Mizuno, S.; Umesaki, Y.; Ishii, Y.; Sugitani, M.; Imaoka, A.; Otsuka, M.; Hasunuma, O.; Kurihara, R.; Iwasaki, A.; Arakawa, Y.

doi:10.1111/j.1365-2036.2004.02268.x

Cited by 397Probiotics and Fermented FoodsInflammatory Bowel DiseaseGut microbiota and health

Randomized placebo‐controlled trial assessing the effect of bifidobacteria‐fermented milk on active ulcerative colitis

Kato, K., Mizuno, S., Umesaki, Y., Ishii, Y., Sugitani, M., Imaoka, A., Otsuka, M., Hasunuma, O. +3 more·2004·Alimentary Pharmacology & Therapeutics

DOI 10.1111/j.1365-2036.2004.02268.x

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Abstract

Summary: Background : Probiotics are efficacious for treating and maintaining remission of ulcerative colitis. Aim : To conduct a randomized placebo‐controlled trial of bifidobacteria‐fermented milk supplementation as a dietary adjunct in treating active ulcerative colitis. Methods : Twenty patients with mild to moderate, active, ulcerative colitis randomly received 100 mL/day of bifidobacteria‐fermented milk or placebo for 12 weeks with conventional treatment. Results : Clinical and endoscopic activity indices and histological scores were similar in the two groups before treatment. Although improvements were significant in both groups, the clinical activity index was significantly lower in the bifidobacteria‐fermented milk than in the placebo group after treatment. The post‐treatment endoscopic activity index and histological score were significantly reduced in the bifidobacteria‐fermented milk, but not the placebo group. Increases in faecal butyrate, propionate and short‐chain fatty acid concentrations were significant in the bifidobacteria‐fermented milk, but not the placebo group. No adverse effects were observed in either group. Conclusion : Supplementation with this bifidobacteria‐fermented milk product is safe and more effective than conventional treatment alone, suggesting possible beneficial effects in managing active ulcerative colitis. This is a pilot study and further larger studies are required to confirm the result these preliminary results.

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Bifidobacteria-fermented milk increased fecal butyrate, propionate and short-chain fatty acid concentrations but ameliorated symptoms in patients affected by UC.
“bifidobacteriafermented milk increased fecal butyrate, propionate and short-chain fatty acid concentrations but ameliorated symptoms in patients affects by UC [242]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [242]

Probiotics in man and animals
AFRC, R. F. (1989) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1989.tb05105.x · Cited by 4,831 · see citing works
Cortisone in Ulcerative Colitis
Truelove, S. C., & Witts, L. J. (1955) · BMJ · doi:10.1136/bmj.2.4947.1041 · Cited by 2,793 · see citing works
Cyclosporine in Severe Ulcerative Colitis Refractory to Steroid Therapy
Lichtiger, S., Present, D. H., Kornbluth, A. A., Gelernt, I. M., Bauer, J. J., Galler, G. W., Michelassi, F., & Hanauer, S. B. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406303302601 · Cited by 1,715 · see citing works
Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial
Gionchetti, P., Rizzello, F., Venturi, A., Brigidi, P., Matteuzzi, D., Bazzocchi, G., Poggioli, G., Miglioli, M., & Campieri, M. (2000) · Gastroenterology · doi:10.1053/gast.2000.9370 · Cited by 1,485 · see citing works
Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial
Gionchetti, P., Rizzello, F., Helwig, U., Venturi, A., Lammers, K. M., Brigidi, P., Vitali, B., Poggioli, G., Miglioli, M., & Campieri, M. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00171-9 · Cited by 1,147 · see citing works
Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial
Rembacken, B., Snelling, A. M., Hawkey, P. M., Chalmers, D. M., & Axon, A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)06343-0 · Cited by 1,100 · see citing works
Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics
Sartor, R. B. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.024 · Cited by 1,053 · see citing works
Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus
Saavedra, J. M., Bauman, N. A., Perman, J. A., Yolken, R. H., Saavedra, J. M., Bauman, N. A., & Oung, I. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91708-6 · Cited by 958 · see citing works
Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis
Mimura, T., Rizzello, F., Helwig, U., Poggioli, G., Schreiber, S., Talbot, I. C., Nicholls, R. J., Gionchetti, P., Campieri, M., & Kamm, M. A. (2003) · Gut · doi:10.1136/gut.53.1.108 · Cited by 912 · see citing works
Double‐blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis
Kruis, W., SCHÜTZ, E., Fric, P., Fixa, B., Judmaier, G., & Stolte, M. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.00225.x · Cited by 774 · see citing works
Lactobacillus species prevents colitis in interleukin 10 gene–deficient mice
Madsen, K. L., Doyle, J. S. G., Jewell, L. D., Tavernini, M. M., & Fedorak, R. N. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70013-2 · Cited by 761 · see citing works
Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation
Harig, J. M., Soergel, K. H., KOMOROWSKI, R. A., & Wood, C. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200105 · Cited by 748 · see citing works
Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis
Scheppach, W. M., Sommer, H., Kirchner, T., Paganelli, G.-M., Bartram, P., Christl, S. U., Richter, F., Dusel, G., & Kasper, H. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91094-k · Cited by 740 · see citing works
Ecological control of the gastrointestinal tract. The role of probiotic flora
Bengmark, S. (1998) · Gut · doi:10.1136/gut.42.1.2 · Cited by 505 · see citing works
Quantitative PCR with 16S rRNA-Gene-Targeted Species-Specific Primers for Analysis of Human Intestinal Bifidobacteria
Matsuki, T., Watanabe, K., Fujimoto, J., Kado, Y., Takada, T., Matsumoto, K., & Tanaka, R. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.1.167-173.2004 · Cited by 498 · see citing works
Inflammatory bowel disease: Immunodiagnostics, immunotherapeutics, and ecotherapeutics
Shanahan, F. (2001) · Gastroenterology · doi:10.1053/gast.2001.22122 · Cited by 371 · see citing works
Randomized Controlled Trial of the Effect of Bifidobacteria-Fermented Milk on Ulcerative Colitis
Ishikawa, H., Akedo, I., Umesaki, Y., Tanaka, R., Imaoka, A., & Otani, T. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719276 · Cited by 369 · see citing works
Self-citation
Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial
Kitajima, H., Sumida, Y., Tanaka, R., Yuki, N., Takayama, H., & Fujimura, M. (1997) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.76.2.f101 · Cited by 315 · see citing works
Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis
Ohkusa, T., Okayasu, I., Ogihara, T., Morita, K., Ogawa, M., & Sato, N. (2002) · Gut · doi:10.1136/gut.52.1.79 · Cited by 300 · see citing works
The effects of Lactobacillus strains and oat fiber on methotrexate- induced enterocolitis in rats
Mao, Y., Nobaek, S., Kasravi, F. B., Adawi, D., Stenram, U., Molin, G., & Jeppsson, B. W. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8690198 · Cited by 296 · see citing works
Butyrate Suppression of Colonocyte NF-κB Activation and Cellular Proteasome Activity
Yin, L., Laevsky, G. S., & Giardina, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105170200 · Cited by 267 · see citing works
Pouchitis: result of microbial imbalance?
Embden, J. G. R.-V., Schouten, W. R., & van Lieshout, L. M. (1994) · Gut · doi:10.1136/gut.35.5.658 · Cited by 255 · see citing works
Butyrate oxidation is impaired in the colonic mucosa of sufferers of quiescent ulcerative colitis.
Chapman, M., Grahn, M. F., Boyle, M. A., Hutton, M. R. E., Rogers, J. E., & Williams, N. S. (1994) · Gut · doi:10.1136/gut.35.1.73 · Cited by 241 · see citing works
Treatment of distal ulcerative colitis with short-chain fatty acid enemas a placebo-controlled trial
Scheppach, W. M., & German-Austrian Scfa Study Group (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02071409 · Cited by 204 · see citing works
The Effect of Exogenous Administration ofLactobacillus reuteriR2LC and Oat Fiber on Acetic Acid-Induced Colitis in the Rat
Fabia, R. B., Ar'Rajab, A., Johansson, M. L., Wïllén, R., Andersson, R. E., Molin, G., & Bengmark, S. (1993) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529309096063 · Cited by 194 · see citing works
Identification, Detection, and Enumeration of Human Bifidobacterium Species by PCR Targeting the Transaldolase Gene
Requena, T., Burton, J. P., Matsuki, T., Munro, K., Simon, M. A., Tanaka, R., Watanabe, K., & Tannock, G. W. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.5.2420-2427.2002 · Cited by 188 · see citing works
Probiotics in inflammatory bowel disease—therapeutic rationale and role
Shanahan, F. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.11.003 · Cited by 133 · see citing works
Characterization of antibody responses against rectal mucosa‐associated bacterial flora in patients with ulcerative colitis
Matsuda, H., Fujiyama, Y., Andoh, A., Ushijima, T., Kajinami, T., & Bamba, T. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02045.x · Cited by 133 · see citing works
Mucosa-associated bacterial flora of the human colon
Poxton, I. R., Brown, R. L., Sawyerr, A. M., & Ferguson, A. (1997) · Journal of Medical Microbiology · doi:10.1099/00222615-46-1-85 · Cited by 114 · see citing works
Treatment of ulcerative colitis with germinated barley foodstuff feeding: a pilot study
Mitsuyama, Saiki, Kanauchi, Iwanaga, Tomiyasu, Nishiyama, Tateishi, Shirachi, Ide, Suzuki, ※., et al. (1998) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1998.00432.x · Cited by 112 · see citing works
Influences of probiotic bacteria on organic acid production by pig caecal bacteriain vitro
Sakata, T., Kojima, T., Fujieda, M., Takahashi, M. P., & Michibata, T. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2002211 · Cited by 108 · see citing works
Prevention of gut inflammation by Bifidobacterium in dextran sulfate-treated gnotobiotic mice associated with Bacteroides strains isolated from ulcerative colitis patients
Setoyama, H., Imaoka, A., Ishikawa, H., & Umesaki, Y. (2003) · Microbes and Infection · doi:10.1016/s1286-4579(02)00080-1 · Cited by 106 · see citing works
Self-citation
Comparison of Bacteroides vulgatus strains in the enhancement of experimental ulcerative colitis
Onderdonk, A. B., Bronson, R. T., & Cisneros, R. L. (1987) · Infection and Immunity · doi:10.1128/iai.55.3.835-836.1987 · Cited by 45 · see citing works
Distribution Analysis of Six PredominantBacteroidesSpecies in Normal Human Feces Using 16S rDNA-Targeted Species-Specific Primers
Miyamoto, Y., Watanabe, K., Tanaka, R., et al. (2002) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v14i3.8239 · Cited by 11 · see citing works
Distribution Analysis of Six Predominant Bacteroides Species in Normal Human Feces Using 16S rDNA-Targeted Species-Specific Primers
Miyamoto, Y., Watanabe, K., Tanaka, R., et al. (2002) · Microbial Ecology in Health and Disease · doi:10.1080/089106002320644302 · Cited by 10 · see citing works

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Goldenberg, J. Z., Ma, S. S., Saxton, J. D., Martzen, M. R., Vandvik, P. O., Thorlund, K., Guyatt, G. H., & Johnston, B. C. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006095.pub3 · Cited by 741 · see citing works
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Authors: Kato, K., Mizuno, S., Umesaki, Y., Ishii, Y., Sugitani, M., Imaoka, A., Otsuka, M., Hasunuma, O., Kurihara, R., Iwasaki, A., & Arakawa, Y.
Affiliations: Nihon University (JP)
Yakult Central Institute (JP)
Corresponding author: Kato, K.
ORCID: Umesaki, Y.
Sugitani, M.
Venue: Alimentary Pharmacology & Therapeutics
Publisher: Wiley
Published: 2004-11
Volume: 20
Issue: 10
Pages: 1133-1141
ISSN: 0269-2813 (ISSN-L)
1365-2036
DOI: 10.1111/j.1365-2036.2004.02268.x
OpenAlex: W2046776539
Cited by: 397
References: 35
Citations by year: 2026: 8 · 2025: 11 · 2024: 20 · 2023: 17 · 2022: 21 · 2021: 23 · 2020: 16 · 2019: 21 · 2018: 16 · 2017: 16 · 2016: 19 · 2015: 16 · 2014: 26 · 2013: 18 · 2012: 18
FWCI: 23.08
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 28 d)
Locations: Alimentary Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: ulcerative colitis, Bifidobacterium, fermented milk, probiotics, dietary supplementation, short-chain fatty acids, butyrate, propionate, endoscopic activity, histological score, clinical activity index, inflammatory bowel disease
MeSH terms: Adult, Bifidobacterium, Colitis, Ulcerative, Colonoscopy, Double-Blind Method, Feces, Female, Humans, Male, Probiotics, Cultured Milk Products

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Randomized placebo‐controlled trial assessing the effect of bifidobacteria‐fermented milk on active ulcerative colitis

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