Cited by 118Gastrointestinal motility and disordersPain Mechanisms and TreatmentsUrinary Bladder and Prostate Research

Alteration of the spinal modulation of nociceptive processing in patients with irritable bowel syndrome

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Coffin, B, Bouhassira, D, Sabaté, J-M, Barbe, L, Jian, R·2004·Gut

Abstract

BACKGROUND: Visceral hypersensitivity has been evidenced in patients with irritable bowel syndrome (IBS) but its mechanisms remain poorly elucidated. We investigated the spinal transmission of nociceptive signals in IBS patients by analysing the effects of rectal distensions on electromyographic recordings of the somatic nociceptive flexion (RIII) reflex, an objective index of spinal nociceptive processes. METHODS: Fourteen IBS and 10 healthy volunteers were included in the study. Slow ramp (40 ml/min) and rapid phasic (900 ml/min, 10, 20, 30, and 40 mm Hg) rectal distensions were randomly performed while the RIII reflex evoked by electrical stimulation of the sural nerve at the ankle was continuously recorded from the ipsilateral biceps femoris. RESULTS: In healthy volunteers, significant progressive inhibition of the RIII reflex was observed during slow ramp distension (61 (13)% of control values) while biphasic effects (facilitation and inhibition) were observed during rapid distensions. In contrast, in IBS patients, the RIII reflex was significantly facilitated during slow ramp distension (139 (15)% of control values) and inhibitions induced by rapid distensions were significantly reduced. Volumes of distension and rectal compliance were similar in both groups. CONCLUSIONS: Our results provide direct evidence that a hyperexcitability of spinal nociceptive processes is present in a large subgroup of IBS patients.

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Crossref · 10.1136/gut.2003.031310

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Research works printed but not linked: 2

  1. Skljarevski V, Ramadan NM. The nociceptive flexion reflex in humans. Pain 2002;96:3-8.
  2. Drossman DA, Grant-Thompson W, Talley NJ, et al. Identification of sub- groups of functionnal gastrointestinal disorders. Gastroenterol Int 1990;3:159-72.

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Authors
Coffin, B., Bouhassira, D., Sabaté, J.-M., Barbe, L., & Jian, R.
Affiliations
  • Hôpital Louis-Mourier (FR)
  • Inserm (FR)
  • Assistance Publique – Hôpitaux de Paris (FR)
Corresponding author
Coffin, B
Venue
Gut
Publisher
BMJ
Published
2004-09-10
Volume
53
Issue
10
Pages
1465-1470
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
OpenAlex
W2076464902
Cited by
117
References
30
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 11
FWCI
6.97
Type
journal article
Language
en
Open access
Locations
  • Gut (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords
irritable bowel syndrome, visceral hypersensitivity, spinal nociceptive processing, rectal distension, RIII reflex, sural nerve stimulation, rectal compliance
MeSH terms
Adult, Aged, Dilatation, Electric Stimulation, Electromyography, Female, Humans, Male, Middle Aged, Nociceptors, Pain Measurement, Rectum, Reflex, Sensation, Spinal Cord, Sural Nerve, Irritable Bowel Syndrome

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