Rapid Response to Cognitive Behavior Therapy Predicts Treatment Outcome in Patients With Irritable Bowel Syndrome

Lackner, Jeffrey M.; Gudleski, Gregory D.; Keefer, Laurie; Krasner, Susan S.; Powell, Cathrine; Katz, Leonard A.

doi:10.1016/j.cgh.2010.02.007

Cited by 76Gastrointestinal motility and disordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesInfant Health and Development

Rapid Response to Cognitive Behavior Therapy Predicts Treatment Outcome in Patients With Irritable Bowel Syndrome

Open access

Lackner, Jeffrey M., Gudleski, Gregory D., Keefer, Laurie, Krasner, Susan S., Powell, Cathrine, Katz, Leonard A.·2010·Clinical Gastroenterology and Hepatology

DOI 10.1016/j.cgh.2010.02.007PMC PMC3144205

Open this paper in CoChat — free account Open PDF

Abstract

Background We sought to determine whether the therapeutic phenomenon of rapid response characterizes patients undergoing CBT for irritable bowel syndrome (IBS). If RR is operating in IBS treatment, a significant proportion of CBT treated patients should achieve a positive response early in treatment (by week 4). We also hypothesized that rapid responders (RR) would be more likely to maintain treatment gains than non rapid responders (NRR). Our secondary goal was to characterize the psychosocial profile of RRs on clinically relevant demographic and clinical variables (e.g., health status, baseline level of IBS symptom severity, distress). Methods 71 individuals ages 18–70 years with a Rome II IBS diagnosis and symptoms of at least moderate severity were randomized to one of 2 CBT treatments: either 10 weekly, one hour sessions (Standard-CBT) or four, one hour sessions over 10 weeks (Minimal Contact-CBT). RRs were classified as patients who 1) reported adequate relief of pain; 2), adequate relief of GI symptoms and 3) a decrease in total IBSSS scores of ≥50 by week 4. Results 30% of CBT treated patients achieved RR by week 4 of treatment. 90–95% of RRs maintained gains at immediate and 3 month follow-up. While RR reported more severe IBS symptoms at baseline, they achieved more substantial and sustained gains (e.g. IBS symptom reduction) than NRRs. Standard- and MC CBT yielded comparable RR rates even though MC CBT patients received 50% less clinic treatment by week 4. Conclusions Rapid response is a potentially important prognostic outcome indicator that has important implications for developing step care approaches for IBS treatment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cgh.2010.02.007

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sudden improvements for 40 to 60% of clients following brief interventions and initial therapy sessions are a well-observed effect in the cognitive behavioural therapies.
“For example, sudden improvements for 40 to 60% of clients following brief interventions and initial therapy sessions are a well-observed effect in the cognitive behavioural therapies [41,42,43,44].”
From Brief and Telehealth Acceptance and Commitment Therapy (ACT) Interventions for Stress in Inflammatory Bowel Disease (IBD): A Series of Single Case Experimental Design (SCED) Studies (2022) · cites this paper as [44]
The paper says that rapid, substantial improvement early in CBT has been observed across a variety of conditions (introductory discussion; page unavailable). Its Results report rapid response in 21 of 71 IBS patients (29.6%) by week four, not the claimed 40–60%; it also does not establish that rate for CBT clients generally or specifically following brief interventions. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Improvements in openness to experience, awareness, and particularly stress and valued action are broadly congruent with the existing literature on brief interventions and improvements early in therapy.
“Improvements in openness to experience, awareness, and particularly stress and valued action are broadly congruent with the existing literature on brief interventions and improvements early in therapy.”
From Brief and Telehealth Acceptance and Commitment Therapy (ACT) Interventions for Stress in Inflammatory Bowel Disease (IBD): A Series of Single Case Experimental Design (SCED) Studies (2022) · cites this paper as [44]
The Discussion (page unavailable in our copy) links early CBT gains in patients with IBS to self-monitoring and suggests it may foster awareness; the paper also describes rapid improvement early in therapy. It does not establish improvements in openness to experience, stress, or valued action, so it supports only part of the claimed congruence. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Little is known about which risk and protective factors matter for any particular therapy.
“More importantly the specific risk and protective factors associated with any specific therapy remain poorly delineated in the literature(34).”
From Randomised clinical trial: Symptoms of the irritable bowel syndrome are improved by a psycho-education group intervention (2013) · cites this paper as [34]
Similar rapid gains are observed in CBT for post-traumatic stress disorder, adolescent depression, binge eating, and irritable bowel syndrome.
“Similar gains are observed in CBT for post-traumatic stress disorder (PTSD; 53 percent of clients), adolescent depression, binge eating (62 percent of clients), and irritable bowel syndrome (30 percent of clients) [41,42,43,44].”
From Brief and Telehealth Acceptance and Commitment Therapy (ACT) Interventions for Stress in Inflammatory Bowel Disease (IBD): A Series of Single Case Experimental Design (SCED) Studies (2022) · cites this paper as [44]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Perceived locus of causality and internalization: Examining reasons for acting in two domains.
Ryan, R. M., & Connell, J. P. (1989) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.57.5.749 · Cited by 3,311 · see citing works
The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress
FRANCIS, C. Y., MORRIS, J., & WHORWELL, P. J. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.142318000.x · Cited by 1,708 · see citing works
The dose-effect relationship in psychotherapy.
Howard, K. I., Kopta, S. M., Krause, M. S., & Orlinsky, D. E. (1986) · American Psychologist · doi:10.1037/0003-066x.41.2.159 · Cited by 1,339 · see citing works
Strategy of outcome research in psychotherapy.
Paul, G. L. (1967) · Journal of Consulting Psychology · doi:10.1037/h0024436 · Cited by 1,043 · see citing works
Brief Symptom Inventory
Derogatis, L. R. (1982) · PsycTESTS Dataset · doi:10.1037/t00789-000 · Cited by 854 · see citing works
Quality of Life in Persons with Irritable Bowel Syndrome (Development and Validation of a New Measure)
Patrick, D. L., Drossman, D. A., Frederick, I. O., Dicesare, J., & Puder, K. L. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018831127942 · Cited by 761 · see citing works
The role of the therapeutic alliance in psychotherapy and pharmacotherapy outcome: Findings in the National Institute of Mental Health Treatment of Depression Collaborative Research Program.
KRUPNICK, J. L., Sotsky, S. M., Simmens, S., Moyer, J., & al, E. (1996) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.64.3.532 · Cited by 732 · see citing works
A Multicenter Comparison of Cognitive-Behavioral Therapy and Interpersonal Psychotherapy for Bulimia Nervosa
Agras, W. S., Walsh, B. T., Fairburn, C. G., Wilson, G. T., & KRAEMER, H. C. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.5.459 · Cited by 712 · see citing works
An Evidence-Based Position Statement on the Management of Irritable Bowel Syndrome
American College of Gastroenterology IBS Task Force (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.122 · Cited by 694 · see citing works
Statistical Considerations in the Intent-to-Treat Principle
Lachin, J. M. (2000) · Controlled Clinical Trials · doi:10.1016/s0197-2456(00)00046-5 · Cited by 652 · see citing works
Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders 1 1This study was registered with ClinicalTrials.gov (trial registry no. NCT00006157).
Drossman, D. A., Toner, B. B., Whitehead, W. E., Diamant, N. E., Dalton, C. B., Duncan, S., Emmott, S., Proffitt, V., Akman, D., Frusciante, K., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00669-3 · Cited by 614 · see citing works
The role of the therapeutic alliance in psychotherapy and pharmacotherapy outcome: Findings in the National Institute of Mental Health Treatment of Depression Collaborative Research Program.
KRUPNICK, J. L., Sotsky, S. M., Simmens, S. J., Moyer, J., Elkin, I., Watkins, J., & Pilkonis, P. A. (1996) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.64.3.532 · Cited by 603 · see citing works
Design of Treatment Trials for Functional Gastrointestinal Disorders
Irvine, E. J., Tack, J., Crowell, M. D., Gwee, K. A., Ke, M., Schmulson, M. J., Whitehead, W. E., & Spiegel, B. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.010 · Cited by 550 · see citing works
Untitled work
(2006) · Cited by 534 · see citing works
The role of nonspecific factors in cognitive-behavior therapy for depression.
Ilardi, S. S., & Craighead, W. E. (1994) · Clinical Psychology: Science and Practice · doi:10.1111/j.1468-2850.1994.tb00016.x · Cited by 501 · see citing works
The Functional Gastrointestinal Disorders: Diagnosis, Pathophysiology, and Treatment : A Multinational Consensus
Drossman, D. A. (1994) · Medical Entomology and Zoology · Cited by 470 · see citing works
Clinical trial: lubiprostone in patients with constipation‐associated irritable bowel syndrome – results of two randomized, placebo‐controlled studies
DROSSMAN, D. A., CHEY, W. D., JOHANSON, J. F., FASS, R., SCOTT, C., PANAS, R., & UENO, R. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03881.x · Cited by 399 · see citing works
Gastrointestinal Illness and the Biopsychosocial Model
Drossman, D. A. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199805000-00007 · Cited by 388 · see citing works
Rome II: The functional gastrointestinal disorders
Mertz, H. (2001) · Gastroenterology · doi:10.1016/s0016-5085(01)83863-4 · Cited by 384 · see citing works
Gender, Age, Society, Culture, and the Patient’s Perspective in the Functional Gastrointestinal Disorders
Chang, L., Toner, B. B., Fukudo, S., Guthrie, E., Locke, G. R., Norton, N. J., & Sperber, A. D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.09.071 · Cited by 374 · see citing works
Fundamentals of neurogastroenterology
Wood, J. D., Alpers, D. H., & Andrews, P. L. R. (1999) · Gut · doi:10.1136/gut.45.2008.ii6 · Cited by 311 · see citing works
A Randomized Controlled Clinical Trial of the Serotonin Type 3 Receptor Antagonist Alosetron in Women With Diarrhea-Predominant Irritable Bowel Syndrome
Camilleri, M., Chey, W. Y., Mayer, E. A., Northcutt, A. R., Heath, A. T., Dukes, G. E., McSorley, D., & Mangel, A. W. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.14.1733 · Cited by 302 · see citing works
Psychological treatments for irritable bowel syndrome: a systematic review and meta-analysis
Lackner, J. M., Mesmer, C., Morley, S., Dowzer, C., & Hamilton, S. (2004) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.72.6.1100 · Cited by 295 · see citing works
Self-citation
Design of Treatment Trials for Functional Gastrointestinal Disorders
Irvine, E. J., Whitehead, W. E., Chey, W. D., Matsueda, K., Shaw, M., Talley, N. J., & Veldhuyzen van Zanten, S. J. O. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.058 · Cited by 286 · see citing works
Irritable Bowel Syndrome
Mayer, E. A. (2008) · New England Journal of Medicine · doi:10.1056/nejmcp0801447 · Cited by 243 · see citing works
Cognitive therapy for depression: Individual differences and the process of change
Fennell, M. J. V., & Teasdale, J. D. (1987) · Cognitive Therapy and Research · doi:10.1007/bf01183269 · Cited by 228 · see citing works
Alosetron controls bowel urgency and provides global symptom improvement in women with diarrhea-predominant irritable bowel syndrome
Lembo, T., Wright, R. A., Bagby, B., Decker, C., Gordon, S., Jhingran, P. M., & Carter, E. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.04128.x · Cited by 191 · see citing works
Self-Administered Cognitive Behavior Therapy for Moderate to Severe Irritable Bowel Syndrome: Clinical Efficacy, Tolerability, Feasibility
Lackner, J. M., Jaccard, J., Krasner, S. S., Katz, L. A., Gudleski, G. D., & Holroyd, K. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.03.004 · Cited by 176 · see citing works
Self-citation
How Does Cognitive Behavior Therapy for Irritable Bowel Syndrome Work? A Mediational Analysis of a Randomized Clinical Trial
Lackner, J. M., Jaccard, J., Krasner, S. S., Katz, L. A., Gudleski, G. D., & Blanchard, E. B. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.014 · Cited by 172 · see citing works
Self-citation
A Randomized Controlled Trial of Cognitive Behavior Therapy, Relaxation Training, and Routine Clinical Care for The Irritable Bowel Syndrome
Boyce, P. M., Talley, N. J., Balaam, B., Koloski, N. A., & Truman, G. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07716.x · Cited by 167 · see citing works
Irritable bowel syndrome: a model of the brain-gut interactions.
Mulak, A., & Bonaz, B. L. (2004) · PubMed · Cited by 161 · see citing works
Psychotherapy in two-plus-one sessions: Outcomes of a randomized controlled trial of cognitive-behavioral and psychodynamic-interpersonal therapy for subsyndromal depression.
Barkham, M., Shapiro, D. A., Hardy, G. E., & Rees, A. (1999) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.67.2.201 · Cited by 159 · see citing works
Treatment of the Seriously Obese Patient
Foreyt, J. P., & Goodrick, G. K. (1993) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199310000-00021 · Cited by 113 · see citing works
The Role of the Therapeutic Alliance in Psychotherapy and Pharmacotherapy Outcome: Findings in the National Institute of Mental Health Treatment of Depression Collaborative Research Program
Krupnick, J. L., Sotsky, S. M., Elkin, I., Simmens, S., Moyer, J., Watkins, J., & Pilkonis, P. A. (2006) · Focus · doi:10.1176/foc.4.2.269 · Cited by 111 · see citing works
The effects of relaxation response meditation on the symptoms of irritable bowel syndrome: results of a controlled treatment study
Keefer, L., & Blanchard, E. B. (2001) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(00)00078-4 · Cited by 104 · see citing works
Self-citation
Toward a stepped care approach to treating problem drinkers: the predictive utility of within‐treatment variables and therapist prognostic ratings
BRESLIN, F. C., SOBELL, M. B., SOBELL, L. C., BUCHAN, G., & CUNNINGHAM, J. A. (1997) · Addiction · doi:10.1111/j.1360-0443.1997.tb02869.x · Cited by 102 · see citing works
Irritable bowel syndrome: Psychosocial assessment and treatment.
Blanchard, E. B. (2001) · American Psychological Association eBooks · doi:10.1037/10393-000 · Cited by 87 · see citing works
Commentary. Rapid response to cognitive behavior therapy
Wilson, G. T. (1999) · Clinical Psychology Science and Practice · doi:10.1093/clipsy/6.3.289 · Cited by 81 · see citing works
Heterogeneity of clinical response during placebo treatment
Quitkin, F. M., Rabkin, J. G., Jw, S., McGrath, P. J., Harrison, W. M., Ross, D. C., TRICAMO, E., Fleiss, J. L., Markowitz, J., & Klein, D. F. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.2.193 · Cited by 78 · see citing works
Predictors of attrition and weight loss in patients treated by moderate and severe caloric restriction.
Wadden, T. A., & Letizia, K. A. (1992) · Cited by 70 · see citing works
Brief Symptom Inventory
Drobnjak, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-39903-0_3 · Cited by 67 · see citing works
Conceptual and methodological issues in comparative studies of psychotherapy and pharmacotherapy, II: Nature and timing of treatment effects
Elkin, I., Pilkonis, P. A., Docherty, J. P., & Sotsky, S. M. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.9.1070 · Cited by 64 · see citing works
A Critical Analysis of the Intent-to-Treat Principle in Prevention Research
Gross, D. A., & Fogg, L. (2004) · The Journal of Primary Prevention · doi:10.1023/b:jopp.0000048113.77939.44 · Cited by 60 · see citing works
TREATMENT FOR IRRITABLE BOWEL SYNDROME
Hadley, S. K., & Gaarder, S. M. (1980) · Inpharma Weekly · doi:10.1007/bf03290989 · Cited by 57 · see citing works
Prediction of treatment outcome among patients with irritable bowel syndrome treated with group cognitive therapy
Blanchard, E. B., Lackner, J. M., Gusmano, R., Gudleski, G. D., Sanders, K. A., Keefer, L., & Krasner, S. S. (2006) · Behaviour Research and Therapy · doi:10.1016/j.brat.2005.01.003 · Cited by 47 · see citing works
Self-citation
Consensus statement on depression, anxiety, and functional gastrointestinal disorders.
Ballenger, J. C., Davidson, J. R. T., Lecrubier, Y., Nutt, D., Lydiard, R. B., & Mayer, E. A. (2001) · PubMed · Cited by 36 · see citing works
Treatment of irritable bowel syndrome
Farthing, M. J. G. (2005) · BMJ · doi:10.1136/bmj.330.7489.429 · Cited by 19 · see citing works

Flagged first, then by citations

4 of the 51 references couldn’t be matched to a known paper.

Sorted by citations

The mucosal immune system: master regulator of bidirectional gut-brain communications
Powell, N., Walker, M. M., & Talley, N. J. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.191 · Cited by 379 · see citing works
A cognitive-behavioral treatment for irritable bowel syndrome using interoceptive exposure to visceral sensations
Craske, M. G., Wolitzky-Taylor, K. B., Labus, J., Wu, S., Frese, M., Mayer, E. A., & Naliboff, B. D. (2011) · Behaviour Research and Therapy · doi:10.1016/j.brat.2011.04.001 · Cited by 243 · see citing works
Psychological Interventions for Irritable Bowel Syndrome and Inflammatory Bowel Diseases
Ballou, S., & Keefer, L. (2017) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.69 · Cited by 167 · see citing works
Self-citation
Diagnosis and management of IBS
Khan, S. H., & Chang, L. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.137 · Cited by 132 · see citing works
Cognitive-behavioral therapy for patients with irritable bowel syndrome: current insights
Kinsinger, S. W. (2017) · Psychology Research and Behavior Management · doi:10.2147/prbm.s120817 · Cited by 119 · see citing works
Cognitive–behavioral therapy for irritable bowel syndrome: A meta-analysis
Li, L., Xiong, L., Zhang, S., Yu, Q., & Chen, M. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.03.006 · Cited by 82 · see citing works
Chronic Constipation in the United States: Results From a Population-Based Survey Assessing Healthcare Seeking and Use of Pharmacotherapy
Oh, S. J., Fuller, G., Patel, D. B., Khalil, C., Spalding, W. M., Nag, A., Spiegel, B. M. R., & Almario, C. V. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000614 · Cited by 79 · see citing works
Behavioural medicine and gastrointestinal disorders: the promise of positive psychology
Keefer, L. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0001-1 · Cited by 69 · see citing works
Self-citation
Randomised clinical trial: Symptoms of the irritable bowel syndrome are improved by a psycho-education group intervention
Labus, J., Gupta, A., Gill, H. K., Posserud, I., Mayer, M., Raeen, H., Bolus, R., Simren, M., Naliboff, B. D., & Mayer, E. A. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12171 · Cited by 64 · see citing works
Durability and Decay of Treatment Benefit of Cognitive Behavioral Therapy for Irritable Bowel Syndrome: 12-Month Follow-Up
Lackner, J. M., Jaccard, J., Radziwon, C. D., Firth, R. S., Gudleski, G. D., Hamilton, F., Katz, L. A., Keefer, L., Krasner, S. S., Ma, C.-X., et al. (2019) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0396-x · Cited by 61 · see citing works
“Missing data across time in all analyses were addressed using chained equation multiple imputation [24].”
Self-citation
Visceral sensitivity as a mediator of outcome in the treatment of irritable bowel syndrome
Wolitzky-Taylor, K. B., Craske, M. G., Labus, J. S., Mayer, E. A., & Naliboff, B. D. (2012) · Behaviour Research and Therapy · doi:10.1016/j.brat.2012.05.010 · Cited by 62 · see citing works
Understanding Gastrointestinal Distress: A Framework for Clinical Practice
Spiegel, B. M. R., Khanna, D., Bolus, R. R., Agarwal, N., Khanna, P. P., & Chang, L. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.383 · Cited by 50 · see citing works
Centrally Acting Therapies for Irritable Bowel Syndrome
Grover, M., & Drossman, D. A. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.003 · Cited by 49 · see citing works
The Irritable Bowel Syndrome Outcome Study (IBSOS): Rationale and design of a randomized, placebo-controlled trial with 12month follow up of self- versus clinician-administered CBT for moderate to severe irritable bowel syndrome
Lackner, J. M., Keefer, L., Jaccard, J. J., Firth, R. S., Brenner, D. M., Bratten, J. R., Dunlap, L. J., Ma, C., & Byroads, M. (2012) · Contemporary Clinical Trials · doi:10.1016/j.cct.2012.07.013 · Cited by 47 · see citing works
Self-citation
Psychological Therapies in Patients with Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Altayar, O., Sharma, V., Prokop, L. J., Sood, A., & Murad, M. H. (2015) · Gastroenterology Research and Practice · doi:10.1155/2015/549308 · Cited by 47 · see citing works
Factors Associated With Efficacy of Cognitive Behavior Therapy vs Education for Patients With Irritable Bowel Syndrome
Lackner, J. M., Jaccard, J. J., Firth, R. S., Krasner, S. S., Hamilton, F. A., Keefer, L., Ma, C., Radziwon, C. D., Sitrin, M. D., Brenner, D. M., et al. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.10.033 · Cited by 45 · see citing works
Self-citation
Does rapid response to two group psychotherapies for binge eating disorder predict abstinence?
Safer, D. L., & Joyce, E. E. (2011) · Behaviour Research and Therapy · doi:10.1016/j.brat.2011.03.001 · Cited by 44 · see citing works
Snapshot of an integrated psychosocial gastroenterology service
Kinsinger, S. W. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i6.1893 · Cited by 41 · see citing works
Prevalence and Characteristics of Abdominal Pain in the United States
Lakhoo, K., Almario, C. V., Khalil, C., & Spiegel, B. M. R. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.06.065 · Cited by 41 · see citing works
Cognitive-behavioral therapy for the management of irritable bowel syndrome
Tang, Q.-L. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i46.8605 · Cited by 37 · see citing works
Both early and late changes in psychological variables relate to treatment outcome for musculoskeletal pain patients at risk for disability
Bergbom, S., Boersma, K., & Linton, S. J. (2012) · Behaviour Research and Therapy · doi:10.1016/j.brat.2012.08.008 · Cited by 31 · see citing works
Early response in cognitive-behavior therapy for syndromes of medically unexplained symptoms
Kleinstäuber, M., Lambert, M. J., & Hiller, W. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1351-x · Cited by 29 · see citing works
Comparison of Laughter Yoga and Anti-Anxiety Medication on Anxiety and Gastrointestinal Symptoms of Patients with Irritable Bowel Syndrome
Tavakoli, T., Davoodi, N., Tabatabaee, T. S. J., Rostami, Z., Mollaei, H., Salmani, F., Ayati, S., & Tabrizi, S. (2019) · Middle East Journal of Digestive Diseases · doi:10.15171/mejdd.2019.151 · Cited by 29 · see citing works
Specific and common mediators of gastrointestinal symptom improvement in patients undergoing education/support vs. cognitive behavioral therapy for irritable bowel syndrome.
Lackner, J. M., & Jaccard, J. J. (2021) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000648 · Cited by 28 · see citing works
Self-citation
Meditation over Medication for Irritable Bowel Syndrome? On Exercise and Alternative Treatments for Irritable Bowel Syndrome
Asare, F., Störsrud, S., & Simrén, M. (2012) · Current Gastroenterology Reports · doi:10.1007/s11894-012-0268-2 · Cited by 28 · see citing works
Psychopharmacological Treatment and Psychological Interventions in Irritable Bowel Syndrome
Sinagra, E., Romano, C., & Cottone, M. (2012) · Gastroenterology Research and Practice · doi:10.1155/2012/486067 · Cited by 27 · see citing works
Brief and Telehealth Acceptance and Commitment Therapy (ACT) Interventions for Stress in Inflammatory Bowel Disease (IBD): A Series of Single Case Experimental Design (SCED) Studies
Lavelle, J., Storan, D., Eswara Murthy, V., De Dominicis, N., Mulcahy, H. E., & McHugh, L. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11102757 · Cited by 23 · see citing works
The Effectiveness of Emotional Schema Therapy on the Emotional Schemas and Emotional Regulation in Irritable Bowel Syndrome: Single Subject Design
Erfan, A., Noorbala, A. A., Amel, S. K., Mohammadi, A., & Adibi, P. (2018) · Advanced Biomedical Research · doi:10.4103/abr.abr_113_16 · Cited by 25 · see citing works
Prediction of symptomatic improvement after exposure-based treatment for irritable bowel syndrome
Ljótsson, B., Andersson, E., Lindfors, P., Lackner, J. M., Grönberg, K., Molin, K., Norén, J., Romberg, K., Andersson, E., Hursti, T. J., et al. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-160 · Cited by 25 · see citing works
Self-citation
The role of mind body interventions in the treatment of irritable bowel syndrome and fibromyalgia
Islam, Z., D’Silva, A., Raman, M., & Nasser, Y. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1076763 · Cited by 26 · see citing works
Nurse-Administered, Gut-Directed Hypnotherapy in IBS: Efficacy and Factors Predicting a Positive Response
Lövdahl, J., Ringström, G., Agerforz, P., Törnblom, H., & Simrén, M. (2015) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2015.1030492 · Cited by 24 · see citing works
Effect of Self-Management Intervention on Cortisol and Daily Stress Levels in Irritable Bowel Syndrome
Deechakawan, W., Cain, K. C., Jarrett, M. E., Burr, R. L., & Heitkemper, M. M. (2013) · Biological Research For Nursing · doi:10.1177/1099800411414047 · Cited by 20 · see citing works
“Over the last two decades, several nonpharmacological intervention studies have achieved improved GI symptoms, psychological distress, and QoL in patients with IBS (Drossman et al., 2003; Lackner et al., 2010; Whitehead et al., 2004), including a comprehensive self-management (CSM) program our team developed (Heitkemp…”
Background
Managing Irritable Bowel Syndrome
Anastasi, J. K., Capili, B., & Chang, M. (2013) · AJN American Journal of Nursing · doi:10.1097/01.naj.0000431911.65473.35 · Cited by 20 · see citing works
Behavioral Strategies for Irritable Bowel Syndrome
Jagielski, C. H., & Riehl, M. E. (2021) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2021.03.006 · Cited by 18 · see citing works
Behavioral avoidance moderates the effect of exposure therapy for irritable bowel syndrome: A secondary analysis of results from a randomized component trial.
Hesser, H., Hedman-Lagerlöf, E., Lindfors, P., Andersson, E., & Ljótsson, B. (2021) · Behaviour Research and Therapy · doi:10.1016/j.brat.2021.103862 · Cited by 19 · see citing works
The effects of cognitive behavioral therapy and drug therapy on quality of life and symptoms of patients with irritable bowel syndrome
Solati, K., & Dehkordi, A. H. (2017) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/japtr.japtr_170_16 · Cited by 17 · see citing works
Linaclotide Reduced Response Time for Irritable Bowel Syndrome With Constipation Symptoms: Analysis of 4 Randomized Controlled Trials
Brenner, D. M., Lacy, B. E., Ford, A. C., Bartolini, W. P., Wu, J. X., Shea, E. P., Bochenek, W. J., Boinpally, R., & Almansa, C. (2022) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002064 · Cited by 14 · see citing works
Skills over pills? A clinical gastroenterologist’s primer in cognitive behavioral therapy for irritable bowel syndrome
Lackner, J. M. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1780118 · Cited by 15 · see citing works
Self-citation
Latent structure of irritable bowel syndrome symptom severity
Jasper, F. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i1.292 · Cited by 12 · see citing works
Gastrointestinal and Hepatic Disease in Fibromyalgia
Schatz, R. A., & Moshiree, B. (2017) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2017.09.009 · Cited by 12 · see citing works
Does multidisciplinary assessment of long-term sickness absentees result in modification of sick-listing diagnoses?
Svedberg, P., Salmi, P., Hagberg, J., Lundh, G., Linder, J., & Alexanderson, K. A. E. (2010) · Scandinavian Journal of Public Health · doi:10.1177/1403494810373674 · Cited by 11 · see citing works
Minimal-Contact Versus Standard Cognitive Behavioral Therapy for Irritable Bowel Syndrome: Cost-Effectiveness Results of a Multisite Trial
Dunlap, L. J., Jaccard, J. J., & Lackner, J. M. (2021) · Annals of Behavioral Medicine · doi:10.1093/abm/kaaa119 · Cited by 11 · see citing works
Self-citation
Study protocol and methods for Easing Pelvic Pain Interventions Clinical Research Program (EPPIC): a randomized clinical trial of brief, low-intensity, transdiagnostic cognitive behavioral therapy vs education/support for urologic chronic pelvic pain syndrome (UCPPS)
Lackner, J. M., Jaccard, J. J., Quigley, B. M., Ablove, T. S., Danforth, T. L., Firth, R. S., Gudleski, G. D., Krasner, S. S., Radziwon, C. D., Vargovich, A. M., et al. (2022) · Trials · doi:10.1186/s13063-022-06554-9 · Cited by 10 · see citing works
Self-citation
Predictors of treatment outcome in cognitive behavioural therapy for chronic pain: a systematic review
Forden, G., Ronaghan, S., Williams, P. J., Fish, S., & Ford, C. E. L. (2023) · Disability and Rehabilitation · doi:10.1080/09638288.2023.2283113 · Cited by 10 · see citing works
Ambivalence over emotional expression and perceived social constraints as moderators of relaxation training and emotional awareness and expression training for irritable bowel syndrome
Holmes, H. J., Thakur, E. R., Carty, J. N., Ziadni, M. S., Doherty, H. K., Lockhart, N. A., Schubiner, H. H., & Lumley, M. A. (2018) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2018.05.002 · Cited by 10 · see citing works
Gastrointestinal Diseases
Keefer, L., Taft, T., & Kiebles, J. L. (2012) · Wiley eBooks · doi:10.1002/9781118133880.hop209016 · Cited by 10 · see citing works
Self-citation
Therapist effects on early change in psychotherapy in a naturalistic setting
Erekson, D. M., Clayson, R. A., Park, S. Y., & Tass, S. (2018) · Psychotherapy Research · doi:10.1080/10503307.2018.1556824 · Cited by 9 · see citing works
Irritable Bowel Syndrome
Beatty, J. A., & Varhabhatla, N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-75775-1.00003-9 · Cited by 9 · see citing works
Do I really have to do my homework? The role of homework compliance in cognitive behavioral therapy for irritable bowel syndrome
Radziwon, C. D., Quigley, B. M., Vargovich, A. M., Krasner, S. S., Gudleski, G. D., Mason, S. R., Borden, A. B., & Lackner, J. M. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104063 · Cited by 7 · see citing works
Self-citation
Influence of trauma on clinical outcomes, quality of life and healthcare resource utilization following psychogastroenterology intervention
Jagielski, C. H., Chey, W. D., & Riehl, M. E. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110481 · Cited by 6 · see citing works
A multidisciplinary approach to the management of disorders of gut-brain interaction: psychopharmacology, psychotherapy, and diet
Flores, F. J. B., Tamez, J. A. G., Winkelman, T., Flores, R. B., & Madva, E. N. (2025) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2025.1637172 · Cited by 5 · see citing works
Cognitive–behavioural therapy for IBS comes home: mapping a route for efficacy and efficiency in the digital age
Lackner, J. M., & Jaccard, J. J. (2019) · Gut · doi:10.1136/gutjnl-2019-318583 · Cited by 5 · see citing works
Self-citation
The timing and magnitude of improvements in depression, anxiety, disability, and pain intensity during an internet-delivered program for chronic pain
Bisby, M. A., Chandra, S. S., Scott, A. J., Dudeney, J., Titov, N., & Dear, B. F. (2023) · The Journal of Pain · doi:10.1016/j.jpain.2023.06.004 · Cited by 4 · see citing works
Abdominal Pain in Irritable Bowel Syndrome (IBS)
Dekel, R., Drossman, D. A., & Sperber, A. D. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1992-5_6 · Cited by 4 · see citing works
Psychological Treatment of Irritable Bowel Syndrome
Quinton, S., & Keefer, L. (2014) · Wiley eBooks · doi:10.1002/9781118453940.ch22 · Cited by 4 · see citing works
Self-citation
Innovative cognitive behavioral therapies for irritable bowel syndrome: processes, predictors, platforms, and outcomes
Lackner, J. M. (2024) · Pain · doi:10.1097/j.pain.0000000000003186 · Cited by 3 · see citing works
Self-citation
“The early bird catches the worm”—Prediction of early response and its importance for treatment outcome in a naturalistic setting of cognitive behaviour therapy
Röhrig, B., Witthöft, M., Herpertz, S., & Petrak, F. (2024) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2956 · Cited by 3 · see citing works
Efficacy and indication optimization of Chinese medicine (Tiao-Chang Ke-Min granules) for diarrhea-predominant irritable bowel syndrome: study protocol for a randomized controlled trial
Li, Q., Zhang, B., Huang, S., Ouyang, W., Xie, J., Wen, Z.-H., & Yang, X. (2018) · Trials · doi:10.1186/s13063-018-2754-9 · Cited by 3 · see citing works
Factors That Predict Magnitude, Timing, and Persistence of Placebo-Like Response in Patients With Irritable Bowel Syndrome
Lackner, J. M., Quigley, B. M., Zilcha‐Mano, S., Radziwon, C. D., Krasner, S. S., Gudleski, G. D., & Enck, P. (2023) · Gastro Hep Advances · doi:10.1016/j.gastha.2023.10.003 · Cited by 3 · see citing works
Self-citation
Predictors of Treatment Success of Psychotherapy in Functional Disorders: A Systematic Review of the Literature
Rometsch, C., Martin, A., & Cosci, F. (2025) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.70075 · Cited by 3 · see citing works
Attrition in parent-child interaction therapy
Liebsack, B. K. (2016) · doi:10.33915/etd.6085 · Cited by 3 · see citing works
Irritable Bowel Syndrome in Inflammatory Bowel Disease
Ryu, K.-H., & Huh, K. (2010) · Intestinal Research · doi:10.5217/ir.2010.8.2.95 · Cited by 2 · see citing works
Psychological Interventions for the Management of Irritable Bowel Syndrome: Understanding the Mind-gut Connection
Verma, N., Arora, A., Wal, A., Singh, C., Shankara, R. K., Singh, B., & Sharma, M. C. (2025) · Current Psychiatry Research and Reviews · doi:10.2174/0126660822325668241118073750 · Cited by 1 · see citing works
Obstáculos en la comunicación entre el cerebro y el intestino
Pletikosić, S., & Tkalčić, M. (2018) · Psihologijske teme · doi:10.31820/pt.27.1.6 · Cited by 2 · see citing works
Psychological Factors and Treatments in Irritable Bowel Syndrome
Weinland, S. R., & Drossman, D. A. (2013) · doi:10.1002/9781118444689.ch10 · Cited by 1 · see citing works
A psychosocial perspective on pediatric functional abdominal pain: risk factors and treatment
van der Veek, S. (2012) · UvA-DARE (University of Amsterdam)
A randomized controlled trial of lifestyle self-monitoring for irritable bowel syndrome in female nursing school students
Okami, Y., Nin, G., Harada, K., Iwasa, M., Kitaoka, K., Saruwatari, A., Aoi, W., Wada, S., Kimura, M., Asano, H., et al. (2013) · Open Journal of Gastroenterology · doi:10.4236/ojgas.2013.38058
Kognitiv beteendeterapi vid IBS (irritable bowel syndrome) : -Kan behandling med kognitiv beteendeterapi ge någon effekt hos personer med IBS?
Edlund, E. (2016) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Editorial Comment from Dr Stranne and Psychotherapist Stranne to Postoperative urinary incontinence exacerbates nocturia‐specific quality of life after robot‐assisted radical prostatectomy
Stranne, J., & Stranne, E. (2016) · International Journal of Urology · doi:10.1111/iju.13219
SVEUČILIŠTE U ZAGREBU MEDICINSKI FAKULTET SVEUČILIŠNI DIPLOMSKI STUDIJ SESTRINSTVA
Bukovina, G. (2014)
Uloga medicinske sestre u liječenju i skrbi bolesnika sa sindromom iritabilnog crijeva
Fakultet, M. (2015)
Irritable Bowel Syndrome-Strategies for Diagnosis and Management
Kassebaum-Ladewski, A. (2021) · Physician Assistant Clinics · doi:10.1016/j.cpha.2021.05.008
Gastrointestinal Conditions
Taft, T., & Riehl, M. E. (2014) · Springer eBooks · doi:10.1007/978-0-387-09817-3_18
The Psychology of Irritable Bowel Syndrome
Ballou, S., & Keefer, L. (2013) · Wiley eBooks · doi:10.1002/9781394260454.ch21
Self-citation
Brain Changes Underlying Irritable Bowel Syndrome Symptom Improvement in Response to Mindfulness‐Based Stress Reduction
Labus, J. S., Tun, G., Savoca, P. W., Delgadillo, D. R., Antony, K. M., Liu, C., Smith, S. R., Serpa, J. G., Stains, J., Naliboff, B. D., et al. (2026) · Neurogastroenterology & Motility · doi:10.1111/nmo.70315
A Review of Cognitive Behavioral Therapy in Irritable Bowel Syndrome
ladani, F. J., & Pourshams, A. (2013) · GOVARESH

Is cognitive behavior therapy an effective treatment for irritable bowel syndrome?
Everard, K. M., & Zoberi, K. S. (2014) · Evidence-Based Practice · doi:10.1097/01.ebp.0000540568.28194.ec
Durability and Decay of Treatment Benefit of Cognitive Behavioral Therapy for Irritable Bowel Syndrome: 12-Month Follow-Up
Lackner, J. M., Jaccard, J., Radziwon, C. D., Firth, R. S., Gudleski, G. D., Hamilton, F., Katz, L. A., Keefer, L., Krasner, S. S., Ma, C.-X., et al. (2019) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0396-x · Cited by 61 · see citing works
Self-citation
Improvement in Gastrointestinal Symptoms After Cognitive Behavior Therapy for Refractory Irritable Bowel Syndrome
Lackner, J. M., Jaccard, J., Keefer, L., Brenner, D. M., Firth, R. S., Gudleski, G. D., Hamilton, F. A., Katz, L. A., Krasner, S. S., Ma, C.-X., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.03.063 · Cited by 191 · see citing works
Self-citation
Self-Administered Cognitive Behavior Therapy for Moderate to Severe Irritable Bowel Syndrome: Clinical Efficacy, Tolerability, Feasibility
Lackner, J. M., Jaccard, J., Krasner, S. S., Katz, L. A., Gudleski, G. D., & Holroyd, K. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.03.004 · Cited by 176 · see citing works
Self-citation
Factors Associated With Efficacy of Cognitive Behavior Therapy vs Education for Patients With Irritable Bowel Syndrome
Lackner, J. M., Jaccard, J. J., Firth, R. S., Krasner, S. S., Hamilton, F. A., Keefer, L., Ma, C., Radziwon, C. D., Sitrin, M. D., Brenner, D. M., et al. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.10.033 · Cited by 45 · see citing works
Self-citation

Authors: Lackner, J. M., Gudleski, G. D., Keefer, L., Krasner, S. S., Powell, C., & Katz, L. A.
Affiliations: University at Buffalo, State University of New York (US)
Northwestern University (US)
Corresponding author: Lackner, Jeffrey M.
ORCID: Lackner, Jeffrey M.
Keefer, Laurie
Venue: Clinical Gastroenterology and Hepatology
Publisher: Elsevier BV
Published: 2010-05
Volume: 8
Issue: 5
Pages: 426-432
ISSN: 1542-3565 (ISSN-L)
DOI: 10.1016/j.cgh.2010.02.007
PMC: PMC3144205
OpenAlex: W2024448573
Semantic Scholar: 5b039f80ff857a20e09be8749ba433acdf529c0a
Cited by: 76
References: 51
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 8
FWCI: 7.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinical Gastroenterology and Hepatology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (77738)
U.S. Public Health Service (67878, 77738)
National Institute of Diabetes and Digestive and Kidney Diseases (U01DK077738, R03DK067878)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Health Professions › Pharmacy › Infant Health and Development
Keywords: irritable bowel syndrome, cognitive behavioral therapy, rapid response, treatment outcomes, symptom severity, maintenance of treatment gains, psychosocial profile, treatment dosage, analgesia, bowel symptoms
MeSH terms: Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Severity of Illness Index, Cognitive Behavioral Therapy, Treatment Outcome, Irritable Bowel Syndrome, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Rapid Response to Cognitive Behavior Therapy Predicts Treatment Outcome in Patients With Irritable Bowel Syndrome

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks