Gastric motility dysfunction in patients with multiple sclerosis assessed by gastric emptying scintigraphy
Open accessAbstract
BACKGROUND: Gastrointestinal tract symptoms are common in patients with multiple sclerosis (MS), especially constipation and/or fecal incontinence. AIMS: To assess gastric emptying in patients with MS to detect the severity of autonomic disturbances in the gastrointestinal tract, and to find the relationship between lower bowel disturbances and the rate of gastric emptying. METHODS: Forty-nine patients with definite MS and 20 control subjects were included in the study. All patients underwent full neurological examination and magnetic resonance imaging of the brain and spinal cord. The labelled meal for gastric emptying scintigraphy consisted of cooked eggs mixed with 3 mCi of technetium-99m colloid, and was followed by serial images at 15 min intervals for 2 h. RESULTS: Five studies were excluded due to technical artifacts. Twenty-one patients (47.7%) demonstrated slow emptying, 15 (34.1%) demonstrated normal and eight (18.2%) demonstrated fast clearance curves. The mean half-time of gastric emptying in MS patients was 96.6±22.4 min and the controls showed a mean half-time of 41.3±18.7 min ( P<0.05). The half-time was longer in patients with constipation; nevertheless, it showed no significant difference compared with patients without constipation (P=0.197). Moreover, although half-time was shorter in patients with fecal incontinence, there was not a significant difference compared with those without fecal incontinence (P=0.654). CONCLUSIONS: The gastric emptying rate is slow in MS patients. As for lower bowel disturbances, the gastric emptying rate was obviously affected in patients complaining of constipation and fecal incontinence, although statistical significance was not reached.
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In a scintigraphic study, multiple sclerosis patients demonstrated delayed gastric emptying compared with controls.
“In a scintigraphic study, MS patients demonstrated delayed gastric emptying compared with controls (el-Maghraby et al., 2005).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as el-Maghraby et al., 2005
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Cites
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011 · see citing works
New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
Poser, C. M., Paty, D. W., Scheinberg, L., McDonald, W. I., Davis, F. A., Ebers, G. C., Johnson, K. P., Sibley, W. A., Silberberg, D. H., & Tourtellotte, W. W. (1983) · Annals of Neurology · doi:10.1002/ana.410130302 · Cited by 7,384 · see citing works
Defining the clinical course of multiple sclerosis
LUBLIN, F. D., & Reingold, S. C. (1996) · Neurology · doi:10.1212/wnl.46.4.907 · Cited by 3,687 · see citing works
A Population-Based Study of Multiple Sclerosis in Twins
Ebers, G. C., Bulman, D. E., Sadovnick, A. D., Paty, D. W., Warren, S., Hader, W. J., Murray, T. J., Seland, T. P., Duquette, P., Grey, T., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152603 · Cited by 637 · see citing works
Fundamentals of neurogastroenterology
Wood, J. D., Alpers, D. H., & Andrews, P. L. R. (1999) · Gut · doi:10.1136/gut.45.2008.ii6 · Cited by 311 · see citing works
MULTIPLE SCLEROSIS AND THE UROLOGIST
Litwiller, S. E., Frohman, E. M., & Zimmern, P. E. (1999) · The Journal of Urology · doi:10.1016/s0022-5347(01)61760-9 · Cited by 281 · see citing works
Sexual dysfunction in multiple sderosis: a case-control study. 1. Frequency and comparison of groups
Zorzon, M., Zivadinov, R., Bosco, A., Bragadin, L. M., Moretti, R., Bonfigli, L., Morassi, P., Iona, L., & Cazzato, G. (1999) · Multiple Sclerosis Journal · doi:10.1177/135245859900500i609 · Cited by 265 · see citing works
Prevalence of bowel dysfunction in multiple sclerosis
Hinds, J. P., Eidelman, B. H., & Wald, A. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)91087-m · Cited by 226 · see citing works
The epidemiology of multiple sclerosis: A general overview
Poser, C. M. (1994) · Annals of Neurology · doi:10.1002/ana.410360805 · Cited by 222 · see citing works
Urinary, faecal and sexual dysfunction in patients with multiple sclerosis
Hennessey, A., Robertson, N. P., Swingler, R. J., & Compston, D. A. S. (1999) · Journal of Neurology · doi:10.1007/s004150050508 · Cited by 222 · see citing works
Prevalence of bowel dysfunction in patients with multiple sclerosis and bladder dysfunction
Chia, Y. W., Fowler, C. J., Kamm, M. A., Henry, M. M., Lemieux, M., & Swash, M. (1995) · Journal of Neurology · doi:10.1007/bf00887825 · Cited by 147 · see citing works
Disturbed gastric and small bowel transit in severe idiopathic constipation
van der Sijp, J. R. M., Kamm, M. A., Nightingale, J. M. D., Britton, K. E., Granowska, M., Mather, S. J., Akkermans, L. M. A., & Lennard-Jones, J. E. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01295909 · Cited by 117 · see citing works
Zorzon, M., Zivadinov, R., Bosco, A., Bragadin, L. M., Moretti, R., Bonfigli, L., Morassi, P., Lg, I., & Cazzato, G. (1999) · Multiple Sclerosis Journal · doi:10.1191/135245899678846456 · Cited by 110 · see citing works
Cardiovascular dysfunction inmultiple sclerosis
Acevedo, A., Nava, C., Arriada, N., Violante, A., & Corona, T. (2000) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2000.101002085.x · Cited by 107 · see citing works
Chronic severe constipation. Prospective motility studies in 25 consecutive patients.
Reynolds, J. C., Ouyang, A., Lee, C. A., Baker, L., Sunshine, A. G., & Cohen, S. (1987) · PubMed · Cited by 106 · see citing works
Sexual disturbances arising from multiple sclerosis
Minderhoud, J. M., Leemhuis, J. G., Kremer, J., Laban, E., & Smits, P. M. L. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1984.tb00827.x · Cited by 105 · see citing works
Bladder, bowel and sexual dysfunction in patients with multiple sclerosis--a cohort study.
Bakke, Å., Myhr, K. M., Grønning, M., & Nyland, H. (1996) · PubMed · Cited by 95 · see citing works
Colonic Dysfunction in Multiple Sclerosis
Glick, M., Meshkinpour, H., Haldeman, S., Bhatia, N. N., & Bradley, W. E. (1982) · Gastroenterology · doi:10.1016/s0016-5085(82)80066-8 · Cited by 92 · see citing works
Cardiovascular Dysfunction in Multiple Sclerosis
Kaplan, T., Berkowitz, A. L., & Samuels, M. A. (2015) · The Neurologist · doi:10.1097/nrl.0000000000000064 · Cited by 87 · see citing works
Disturbances of ano-rectal function in multiple sclerosis
Nordenbo, A. M., Andersen, J. R., & Andersen, J. T. (1996) · Journal of Neurology · doi:10.1007/bf00900497 · Cited by 73 · see citing works
Chia, Y. W., Gill, K. P., Jameson, J. S., Forti, A. D., Henry, M. M., Swash, M., & Shorvon, P. J. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.60.1.31 · Cited by 61 · see citing works
Waldron, D. J., Horgan, P. G., Patel, F., Maguire, R., & Given, H. E. (1993) · International Journal of Colorectal Disease · doi:10.1007/bf00290311 · Cited by 49 · see citing works
Parity as a Factor in Incontinence in Multiple Sclerosis
Swash, M., Snooks, S. J., & Chalmers, D. H. K. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520170034018 · Cited by 45 · see citing works
Genetics and multiple sclerosis: An overview
Ebers, G. C. (1994) · Annals of Neurology · doi:10.1002/ana.410360705 · Cited by 39 · see citing works
Gastrointestinal dysfunction in multiple sclerosis
Sullivan, S., & Ebers, G. C. (1983) · Gastroenterology · doi:10.1016/0016-5085(83)90414-6 · Cited by 32 · see citing works
Bladder, bowel, and sexual dysfunction in multiple sclerosis
Hawker, K., & Frohman, E. M. (2001) · Current Treatment Options in Neurology · doi:10.1007/s11940-001-0002-0 · Cited by 21 · see citing works
Sensory-motor and genito-sphincter dysfunctions in multiple sclerosis
Gallien, P., & Robineau, S. (1999) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(99)80109-7 · Cited by 19 · see citing works
Gastroparesis with multiple sclerosis.
Gupta, Y. K. (1984) · PubMed · Cited by 17 · see citing works
Gastric emptying of mixed solid-liquid meal in patients with intestinal pseudoobstruction
Mayer, E. A., ELASHOFF, J. D., Hawkins, R. A., Berquist, W. E., & Taylor, I. L. (1988) · Digestive Diseases and Sciences · doi:10.1007/bf01536624 · Cited by 17 · see citing works
Gastrointestinal Dysfunction in Multiple Sclerosis
Fowler, C., & Henry, M. M. (1996) · Seminars in Neurology · doi:10.1055/s-2008-1040985 · Cited by 15 · see citing works
Gastroparesis With Multiple Sclerosis
Gupta, Y. K. (1984) · JAMA · doi:10.1001/jama.1984.03350010022007 · Cited by 13 · see citing works
Gastric outlet obstruction in a patient with multiple sclerosis
Graves, M. C. (1981) · Annals of Neurology · doi:10.1002/ana.410100419 · Cited by 13 · see citing works
Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Frontoni M, Giubilei F. Autonomic dysfunction in MS. Int MS J 2000;6:79-87.
- Camilleri M. Autonomic regulation of gastrointestinal motility. In: Low P, ed. Clinical Autonomic Disorders: Evaluation and Management, 2nd edn. Philadelphia: Lippincott-Raven, 1997:135-45.
Cited by
Sorted by citations
Autonomic dysfunction in multiple sclerosis
Haensch, C., & Jörg, J. (2006) · Journal of Neurology · doi:10.1007/s00415-006-1102-2 · Cited by 131 · see citing works
van Amerongen, G., Kanhai, K., Baakman, A. C., Heuberger, J., Klaassen, E., Beumer, T. L., Strijers, R. L. M., Killestein, J., van Gerven, J., Cohen, A., et al. (2018) · Clinical Therapeutics · doi:10.1016/j.clinthera.2017.01.016 · Cited by 86 · see citing works
Awad, R. A. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i46.5035 · Cited by 81 · see citing works
Autonomic dysfunction in multiple sclerosis
Adamec, I., & Habek, M. (2013) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2013.09.026 · Cited by 68 · see citing works
Bishop, E. S., Holt, E. A., Joyce, E. J., Haag, M. M., Mawe, S., Hennig, G. W., Lavoie, B. A., Applebee, A., Teuscher, C., & Mawe, G. M. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13349 · Cited by 65 · see citing works
Autonomic dysfunction in multiple sclerosis
Racosta, J. M., Kimpinski, K., Morrow, S. A., & Kremenchutzky, M. (2015) · Autonomic Neuroscience · doi:10.1016/j.autneu.2015.06.001 · Cited by 65 · see citing works
Bhargava, P., Steele, S. U., Waubant, E. L., Revirajan, N., Marcus, J. F., Dembele, M., Cassard, S. D., Hollis, B. W., Crainiceanu, C. M., & Mowry, E. M. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458515600248 · Cited by 64 · see citing works
Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review
Nusrat, S., Gulick, E. E., Levinthal, D. J., & Bielefeldt, K. (2012) · ISRN Neurology · doi:10.5402/2012/376023 · Cited by 53 · see citing works
Autonomic Dysregulation in Multiple Sclerosis
Pintér, A., Cseh, D., Sárközi, A., Illigens, B. M. W., & Siepmann, T. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160816920 · Cited by 50 · see citing works
Cardiovascular autonomic dysfunction in multiple sclerosis: A meta-analysis
Racosta, J. M., Sposato, L. A., Morrow, S. A., Cipriano, L. E., Kimpiski, K., & Kremenchutzky, M. (2015) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2015.02.002 · Cited by 47 · see citing works
Progressive Impairment of Autonomic Control of Heart Rate in Patients with Multiple Sclerosis
Mahović, D., & Lakušić, N. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.11.009 · Cited by 46 · see citing works
Gastrointestinal Dysmotility in the Elderly
Gidwaney, N. G., Bajpai, M., & Chokhavatia, S. (2016) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000650 · Cited by 29 · see citing works
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Foschi, M., Giannini, G., Merli, E., Mancinelli, L., Zenesini, C., Viti, B., Guaraldi, P., Cortelli, P., & Lugaresi, A. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04620-1 · Cited by 23 · see citing works
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Zhang, Y., Liu, G., Duan, Y., Han, X., Dong, H., & Geng, J. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.11.004 · Cited by 15 · see citing works
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Sakakibara, R. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102795 · Cited by 11 · see citing works
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Duffey, K. (2020) · Annals of Gastroenterology · doi:10.20524/aog.2020.0475 · Cited by 6 · see citing works
Macronutrients Intake in Iranian Multiple Sclerosis Patients
S, M. M., Taleban, F. A., & Ghafarpoor, M. (2007) · Journal of Medical Sciences(Faisalabad) · doi:10.3923/jms.2007.422.426 · Cited by 6 · see citing works
Current understanding of cardiovascular autonomic dysfunction in multiple sclerosis
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- Authors
- El-Maghraby, T. A., Shalby, N. M., Al-Tawdy, M. H., & Salem, S. S.
- Affiliations
- Cairo University (EG)
- Venue
- Canadian Journal of Gastroenterology
- Publisher
- Wiley
- Published
- 2005
- Volume
- 19
- Issue
- 3
- Pages
- 141-145
- ISSN
- 0835-7900 (ISSN-L)
- OpenAlex
- W1960582838
- Cited by
- 35
- References
- 33
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 3 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 6 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Canadian Journal of Gastroenterology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- multiple sclerosis, gastric emptying, constipation, fecal incontinence, autonomic dysfunction, gastrointestinal symptoms
- MeSH terms
- Adolescent, Adult, Female, Gastric Emptying, Humans, Male, Middle Aged, Multiple Sclerosis, Radionuclide Imaging, Severity of Illness Index, Stomach
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