Cited by 1,011Gut microbiota and healthInfant Nutrition and HealthMaternal and Perinatal Health Interventions

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section

Open access

Jakobsson, Hedvig E, Abrahamsson, Thomas R, Jenmalm, Maria C, Harris, Keith, Quince, Christopher, Jernberg, Cecilia, Björkstén, Bengt, Engstrand, Lars, Andersson, Anders F·2014·Gut

DOI 10.1136/gutjnl-2012-303249

Open this paper in CoChat — free account

Abstract

OBJECTIVE: The early intestinal microbiota exerts important stimuli for immune development, and a reduced microbial exposure as well as caesarean section (CS) has been associated with the development of allergic disease. Here we address how microbiota development in infants is affected by mode of delivery, and relate differences in colonisation patterns to the maturation of a balanced Th1/Th2 immune response. DESIGN: The postnatal intestinal colonisation pattern was investigated in 24 infants, born vaginally (15) or by CS (nine). The intestinal microbiota were characterised using pyrosequencing of 16S rRNA genes at 1 week and 1, 3, 6, 12 and 24 months after birth. Venous blood levels of Th1- and Th2-associated chemokines were measured at 6, 12 and 24 months. RESULTS: Infants born through CS had lower total microbiota diversity during the first 2 years of life. CS delivered infants also had a lower abundance and diversity of the Bacteroidetes phylum and were less often colonised with the Bacteroidetes phylum. Infants born through CS had significantly lower levels of the Th1-associated chemokines CXCL10 and CXCL11 in blood. CONCLUSIONS: CS was associated with a lower total microbial diversity, delayed colonisation of the Bacteroidetes phylum and reduced Th1 responses during the first 2 years of life.

Integrity signals

Registry

Crossref · 10.1136/gutjnl-2012-303249

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies.
Klindworth, A., Pruesse, E., Schweer, T., Peplies, J., Quast, C., Horn, M., & Glöckner, F. O. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks808 · Cited by 8,850
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
The measurement of diversity in different types of biological collections
Pielou, E. C. (1966) · Journal of Theoretical Biology · doi:10.1016/0022-5193(66)90013-0 · Cited by 6,021
Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774
Nonparametric estimation of the number of classes in a population
Chao, A. (1984) · Scandinavian Journal of Statistics · Cited by 4,263
Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Transitions in bacterial communities along the 2000 km salinity gradient of the Baltic Sea
Herlemann, D. P. R., Labrenz, M., Jürgens, K., Bertilsson, S., Waniek, J. J., & Andersson, A. F. (2011) · The ISME Journal · doi:10.1038/ismej.2011.41 · Cited by 2,885

Show all 55 references

Sorted by citations

Items 201–300 of 1,000

Shaping Microbiota During the First 1000 Days of Life
Selma‐Royo, M., Tarrazó, M., García‐Mantrana, I., Gómez-Gallego, C., Salminen, S., & Collado, M. C. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_312 · Cited by 98
On the origin of species: Factors shaping the establishment of infant's gut microbiota
van Best, N., Hornef, M. W., Savelkoul, P. H. M., & Penders, J. (2015) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21113 · Cited by 96
Probiotic, Prebiotic, and Brain Development
Cerdó, T., Ruiz-Rodriguez, A., Suárez, A., & Campoy, C. (2017) · Nutrients · doi:10.3390/nu9111247 · Cited by 103
Microbiome and Asthma: Microbial Dysbiosis and the Origins, Phenotypes, Persistence, and Severity of Asthma
Valverde-Molina, J., & García-Marcos, L. (2023) · Nutrients · doi:10.3390/nu15030486 · Cited by 92
Mode of Delivery Shapes Gut Colonization Pattern and Modulates Regulatory Immunity in Mice
Hansen, C. H. F., Andersen, L. S. F., Krych, Ł., Metzdorff, S. B., Hasselby, J. P., Skov, S., Nielsen, D. S., Buschard, K., Hansen, L. H., & Hansen, A. K. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400085 · Cited by 95
The Neonatal Microbiome and Its Partial Role in Mediating the Association between Birth by Cesarean Section and Adverse Pediatric Outcomes
Montoya‐Williams, D., Lemas, D. J., Spiryda, L. B., Patel, K., Carney, O. O., Neu, J., & Carson, T. L. (2018) · Neonatology · doi:10.1159/000487102 · Cited by 94
Microbiota-gut-brain axis and toll-like receptors in Alzheimer’s disease
Lin, C., Zhao, S., Zhu, Y., Fan, Z., Wang, J., Zhang, B., & Chen, Y. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.09.008 · Cited by 94
The Potential Effects of Probiotics and ω-3 Fatty Acids on Chronic Low-Grade Inflammation
Hutchinson, A. N., Tingö, L., & Brummer, R. J. (2020) · Nutrients · doi:10.3390/nu12082402 · Cited by 92
Gut microbiota development across the lifespan: Disease links and health‐promoting interventions
Schoultz, I., Claesson, M. J., Domínguez-Bello, M. G., Hållenius, F. F., Konturek, P. C., Korpela, K., Laursen, M. F., Penders, J., Roager, H. M., Vatanen, T., et al. (2025) · Journal of Internal Medicine · doi:10.1111/joim.20089 · Cited by 108
Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy
Yasmin, F., Tun, H. M., Konya, T., Guttman, D. S., Chari, R. S., Field, C. J., Becker, A. B., Mandhane, P. J., Turvey, S. E., Subbarao, P., et al. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00200 · Cited by 89
Delayed Establishment of Gut Microbiota in Infants Delivered by Cesarean Section
Kim, G., Bae, J., Kim, M. J., Kwon, H., Park, G., Kim, S., Choe, Y. H., Kim, J., Park, S.-H., Choe, B., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.02099 · Cited by 95
Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation
Chua, L. L., Rajasuriar, R., Azanan, M. S., Abdullah, N. K., Tang, M. S., Lee, S. C., Woo, Y. L., Lim, Y. A. L., Ariffin, H., & Loke, P. (2017) · Microbiome · doi:10.1186/s40168-017-0250-1 · Cited by 94
Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease
Mohammadkhah, A. I., Simpson, E. B., Patterson, S. G., & Ferguson, J. F. (2018) · Children · doi:10.3390/children5120160 · Cited by 90
Inflammatory Bowel Disease: A Potential Result from the Collusion between Gut Microbiota and Mucosal Immune System
Yue, B., Luo, X., Yu, Z., Mani, S., Wang, Z., & Dou, W. (2019) · Microorganisms · doi:10.3390/microorganisms7100440 · Cited by 86
Probiotic Supplementation during the Perinatal and Infant Period: Effects on gut Dysbiosis and Disease
Navarro‐Tapia, E., Sebastiani, G., Sailer, S., Almeida-Toledano, L., Serra-Delgado, M., García‐Algar, Ó., & Andreu-Férnández, V. (2020) · Nutrients · doi:10.3390/nu12082243 · Cited by 86
Impact of Delivery Mode on Infant Gut Microbiota
Korpela, K. (2021) · Annals of Nutrition and Metabolism · doi:10.1159/000518498 · Cited by 87
The microbiome during pregnancy and early postnatal life
Neu, J. (2016) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2016.05.001 · Cited by 88
Gut Microbiota in Celiac Disease: Is There Any Role for Probiotics?
Pecora, F., Persico, F., Gismondi, P., Fornaroli, F., Iuliano, S., de’Angelis, G. L., & Esposito, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00957 · Cited by 88
Fecal Microbiome and Food Allergy in Pediatric Atopic Dermatitis: A Cross-Sectional Pilot Study
Fieten, K. B., Totté, J. E. E., Levin, E., Reyman, M., Meijer, Y., Knulst, A. C., Schuren, F. H. J., & Pasmans, S. G. M. A. (2018) · International Archives of Allergy and Immunology · doi:10.1159/000484897 · Cited by 87
Immaculate conceptions: Micro-CT analysis of diagenesis in Romano-British infant skeletons
Booth, T. J., Redfern, R. C., & Gowland, R. L. (2016) · Journal of Archaeological Science · doi:10.1016/j.jas.2016.08.007 · Cited by 84
Common skin bacteria protect their host from oxidative stress through secreted antioxidant RoxP
Andersson, T., Ertürk Bergdahl, G., Saleh, K., Magnúsdóttir, H., Stødkilde, K., Andersen, C. B. F., Lundqvist, K., Jensen, A., Brüggemann, H., & Lood, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-40471-3 · Cited by 82
Current evidence linking diet to gut microbiota and brain development and function
Ceppa, F., Mancini, A., & Tuohy, K. M. (2018) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2018.1462309 · Cited by 83
Gut Microbiome and the Development of Food Allergy and Allergic Disease
Prince, B. T., Mandel, M. J., Nadeau, K. C., & Singh, A. M. (2015) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2015.07.007 · Cited by 83
Gut Microbiota Influence in Hematological Malignancies: From Genesis to Cure
Uribe‐Herranz, M., Klein-González, N., Rodríguez‐Lobato, L. G., Juan, M., & de Larrea, C. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031026 · Cited by 84
Analysis of matched skin and gut microbiome of patients with vitiligo reveals deep skin dysbiosis: link with mitochondrial and immune changes
Bzioueche, H., Simonyté Sjödin, K., West, C. E., Khemis, A., Rocchi, S., Passeron, T., & Tulic, M. K. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.01.036 · Cited by 77
Role of the Microbiome in Food Allergy
Ho, H.-E., & Bunyavanich, S. (2018) · Current Allergy and Asthma Reports · doi:10.1007/s11882-018-0780-z · Cited by 88
Acquisition, transmission and strain diversity of human gut-colonizing crAss-like phages
Siranosian, B. A., Tamburini, F. B., Sherlock, G., & Bhatt, A. S. (2020) · Nature Communications · doi:10.1038/s41467-019-14103-3 · Cited by 74
Interactions of probiotics and prebiotics with the gut microbiota
Ballan, R., Battistini, C., Xavier-Santos, D., & Saad, S. M. I. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.03.008 · Cited by 84
Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant
Vongbhavit, K., & Underwood, M. A. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.01.006 · Cited by 79
Composition of gut microbiota in infants in China and global comparison
Kuang, Y., Li, S., Guo, Y. G., Lu, J., He, J., Luo, B.-J., Jiang, F.-J., Shen, H., Papasian, C. J., Pang, H., et al. (2016) · Scientific Reports · doi:10.1038/srep36666 · Cited by 79
Development of Microbiota in Infants and its Role in Maturation of Gut Mucosa and Immune System
Ximénez, C., & Torres, J. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.11.007 · Cited by 88
A good start in life is important—perinatal factors dictate early microbiota development and longer term maturation
Wang, S., Egan, M., Ryan, C. A., Boyaval, P., Dempsey, E. M., Ross, R. P., & Stanton, C. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa030 · Cited by 80
Comparative Analysis of the Gut Microbial Communities in Forest and Alpine Musk Deer Using High-Throughput Sequencing
Hu, X., Liu, G., Shafer, A. B. A., Wei, Y., Zhou, J., Lin, S., Wu, H., Zhou, M., Hu, D., & Liu, S. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00572 · Cited by 78
Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD
Jiang, X., Zheng, J., Zhang, S., Wang, B., Wu, C., & Guo, X. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00361 · Cited by 80
Role of cesarean section in the development of neonatal gut microbiota: A systematic review
Shaterian, N., Abdi, F., Ghavidel, N., & Alidost, F. (2021) · Open Medicine · doi:10.1515/med-2021-0270 · Cited by 85
Identification of early environmental risk factors for irritable bowel syndrome and dyspepsia
Koloski, N. A., Jones, M., Weltman, M., Kalantar, J. S., Bone, C., Gowryshankar, A., Walker, M. M., & Talley, N. J. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12626 · Cited by 78
Susceptibility to Campylobacter Infection Is Associated with the Species Composition of the Human Fecal Microbiota
Dicksved, J., Ellström, P., Engstrand, L. G., & Rautelin, H. I. K. (2014) · mBio · doi:10.1128/mbio.01212-14 · Cited by 77
Pre‐ and probiotics for allergy prevention: time to revisit recommendations?
Forsberg, A., West, C. E., Prescott, S. L., & Jenmalm, M. C. (2016) · Clinical & Experimental Allergy · doi:10.1111/cea.12838 · Cited by 79
Dysbiosis of gut microbiota in inflammatory bowel disease: Current therapies and potential for microbiota-modulating therapeutic approaches
Alshehri, D., Saadah, O. I., Mosli, M. H., Edris, S., Al-Hindi, R. R., & Bahieldin, A. (2020) · Biomolecules and Biomedicine · doi:10.17305/bjbms.2020.5016 · Cited by 82
The role of the microbiome in gastrointestinal inflammation
Sanders, D. J., Inniss, S., Sebepos‐Rogers, G., Rahman, F. Z., & Smith, A. M. (2021) · Bioscience Reports · doi:10.1042/bsr20203850 · Cited by 82
Establishment of the early-life microbiome: a DOHaD perspective
Stinson, L. F. (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174419000588 · Cited by 77
Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes
Nielsen, D. S., Krych, Ł., Buschard, K., Hansen, C. H. F., & Hansen, A. K. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.010 · Cited by 79
Sex hormones, intestinal inflammation, and the gut microbiome: Major influencers of the sexual dimorphisms in obesity
Brettle, H., Tran, V., Drummond, G. R., Franks, A. E., Petrovski, S., Vinh, A., & Jelinic, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.971048 · Cited by 81
A Review of the Relationship between Gut Microbiome and Obesity
Zsálig, D., Berta, A., Tóth, V., Szabó, Z., Klara, S. M., Figler, M., Pusztafalvi, H., & Polyák, É. (2023) · Applied Sciences · doi:10.3390/app13010610 · Cited by 79
Birthmode and environment-dependent microbiota transmission dynamics are complemented by breastfeeding during the first year
Selma‐Royo, M., Dubois, L., Manara, S., Armanini, F., Cabrera‐Rubio, R., Valles‐Colomer, M., González, S., Llorca, A. P., Escuriet, R., Bode, L., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.05.005 · Cited by 76
New insights into the hygiene hypothesis in allergic diseases
Penders, J., Gerhold, K., Thijs, C. T., Zimmermann, K., Wahn, U., Lau, S., & Hamelmann, E. H. (2014) · Gut Microbes · doi:10.4161/gmic.27905 · Cited by 84
Microbiome Diversity and Asthma and Allergy Risk
Legatzki, A., Rösler, B., & von Mutius, E. (2014) · Current Allergy and Asthma Reports · doi:10.1007/s11882-014-0466-0 · Cited by 75
Maternal and early life exposures and their potential to influence development of the microbiome
Bolte, E., Moorshead, D., & Aagaard, K. M. (2022) · Genome Medicine · doi:10.1186/s13073-021-01005-7 · Cited by 78
Early-life gut microbiome and cow’s milk allergy- a prospective case - control 6-month follow-up study
Dong, P., Feng, J., Yan, D., Lyu, Y., & Xu, X. (2017) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.11.051 · Cited by 73
Microbiota and Neurodevelopmental Trajectories: Role of Maternal and Early-Life Nutrition
Codagnone, M. G., Stanton, C., O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2019) · Annals of Nutrition and Metabolism · doi:10.1159/000499144 · Cited by 74
Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator
Salazar, J., Durán, P., Díaz, M. P., Chacín, M., Santeliz, R., Mengual, E., Gutiérrez, E., León, X., Díaz, A., Bernal, M., et al. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20105845 · Cited by 71
Gut bacterial dysbiosis in children with intractable epilepsy
Lee, K., Kim, N., Shim, J. O., & Kim, G.-H. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm10010005 · Cited by 70
Antibiotics at birth and later antibiotic courses: effects on gut microbiota
Ainonen, S., Tejesvi, M. V., Mahmud, M. R., Paalanne, N., Pokka, T. M.-L., Li, W., Nelson, K. E., Salo, J., Renko, M., Vänni, P., et al. (2021) · Pediatric Research · doi:10.1038/s41390-021-01494-7 · Cited by 71
Minimally Invasive Sampling Method Identifies Differences in Taxonomic Richness of Nasal Microbiomes in Young Infants Associated with Mode of Delivery
Shilts, M. H., Rosas‐Salazar, C., Tovchigrechko, A., Larkin, E. K., Torralba, M., Akopov, A., Halpin, R., Peebles, R. S., Moore, M. L., Anderson, L. J., et al. (2015) · Microbial Ecology · doi:10.1007/s00248-015-0663-y · Cited by 70
Extracellular Membrane Vesicles from Lactobacilli Dampen IFN-γ Responses in a Monocyte-Dependent Manner
Forsberg, M. M., Björkander, S., Pang, Y., Lundqvist, L., Ndi, M., Ott, M., Escribá, I. B., Jaeger, M.-C., Roos, S., & Sverremark‐Ekström, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-53576-6 · Cited by 74
High-Throughput Analysis Reveals Seasonal Variation of the Gut Microbiota Composition Within Forest Musk Deer (Moschus berezovskii)
Hu, X., Liu, G., Li, Y., Wei, Y., Lin, S., Liu, S., Zheng, Y., & Hu, D. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01674 · Cited by 69
Ethnic diversity in infant gut microbiota is apparent before the introduction of complementary diets
Xu, J. Y., Lawley, B., Wong, G., Otal, A., Chen, L., Ying, T. J., Lin, X., Pang, W. W., Yap, F. K. P., Chong, Y. S., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1756150 · Cited by 68
The Potential Link between Gut Microbiota and IgE-Mediated Food Allergy in Early Life
Molloy, J., Allen, K. J., Collier, F., Tang, M. L. K., Ward, A. C., & Vuillermin, P. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10127235 · Cited by 69
The impact of Caesarean section on the infant gut microbiome
Hoang, D. M., Levy, E. I., & Vandenplas, Y. (2020) · Acta Paediatrica · doi:10.1111/apa.15501 · Cited by 70
Impact of the mother's gut microbiota on infant microbiome and brain development
Mady, E. A., Doghish, A. S., El‐Dakroury, W. A., Elkhawaga, S. Y., Ismail, A., El‐Mahdy, H. A., Elsakka, E. G. E., & El‐Husseiny, H. M. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105195 · Cited by 73
Early exposure to agricultural soil accelerates the maturation of the early-life pig gut microbiota
Vo, N., Tsai, T.-C., Maxwell, C., & Carbonero, F. G. (2017) · Anaerobe · doi:10.1016/j.anaerobe.2017.02.022 · Cited by 67
Role of the intestinal microbiota in the immunomodulation of influenza virus infection
Chen, C.-J., Wu, G.-H., Kuo, R.-L., & Shih, S.-R. (2017) · Microbes and Infection · doi:10.1016/j.micinf.2017.09.002 · Cited by 67
MAMI: a birth cohort focused on maternal-infant microbiota during early life
on behalf of MAMI team, García‐Mantrana, I., Alcántara, C., Selma‐Royo, M., Boix-Amorós, A., Dzidic, M., Gimeno-Alcañiz, J. V., Úbeda-Sansano, I., Sorribes‐Monrabal, I., Escuriet, R., et al. (2019) · BMC Pediatrics · doi:10.1186/s12887-019-1502-y · Cited by 67
Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges
Ailioaie, L. M., & Litscher, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094942 · Cited by 70
Associations of Birth Factors and Socio-Economic Status with Indicators of Early Emotional Development and Mental Health in Childhood: A Population-Based Linkage Study
Guhn, M., Emerson, S. D., Mahdaviani, D., & Gadermann, A. (2019) · Child Psychiatry & Human Development · doi:10.1007/s10578-019-00912-6 · Cited by 67
Obesity and overweight: Impact on maternal and milk microbiome and their role for infant health and nutrition
García‐Mantrana, I., & Collado, M. C. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201501018 · Cited by 65
Factors Influencing the Intestinal Microbiome During the First Year of Life
Zimmermann, P., & Curtis, N. C. (2018) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000002103 · Cited by 69
Intestinal microbiome as a risk factor for urinary tract infections in children
Paalanne, N., Husso, A., Salo, J., Pieviläinen, O., Tejesvi, M. V., Koivusaari, P., Pirttilä, A. M., Pokka, T. M.-L., Mattila, S., Jyrkäs, J., et al. (2018) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-018-3322-7 · Cited by 66
Early life gut microbiome and its impact on childhood health and chronic conditions
Núñez, H., Nieto, P. A., Mars, R. A. T., Ghavami, M., Hoy, C. S., & Sukhum, K. V. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2463567 · Cited by 80
The Microbiome and Sustainable Healthcare
Dietert, R. R., & Dietert, J. M. (2015) · Healthcare · doi:10.3390/healthcare3010100 · Cited by 71
Microbiome and its impact on gastrointestinal atopy
Muir, A. B., Benitez, A., Dods, K. K., Spergel, J. M., & Fillon, S. (2016) · Allergy · doi:10.1111/all.12943 · Cited by 66
Current understanding of the role of gut dysbiosis in type 1 diabetes
Abdellatif, A. M., & Sarvetnick, N. (2019) · Journal of Diabetes · doi:10.1111/1753-0407.12915 · Cited by 65
The Role of Microbiomes in Pregnant Women and Offspring: Research Progress of Recent Years
Yao, Y., Cai, X. T., Chen, C., Fang, H., Zhao, Y., Fei, W., Chen, F., & Zheng, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00643 · Cited by 62
Does allergy begin in utero?
Lockett, G. A., Huoman, J., & Holloway, J. W. (2015) · Pediatric Allergy and Immunology · doi:10.1111/pai.12408 · Cited by 64
Neonatal outcomes of waterbirth: a systematic review and meta-analysis
Taylor, H. M., Kleine, I., Bewley, S., Loucaides, E., & Sutcliffe, A. G. (2016) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2015-309600 · Cited by 63
Maternal influence on the fetal microbiome in a population-based study of the first-pass meconium
Tapiainen, T., Paalanne, N., Tejesvi, M. V., Koivusaari, P., Korpela, K., Pokka, T. M.-L., Salo, J., Kaukola, T., Pirttilä, A. M., Uhari, M. K., et al. (2018) · Pediatric Research · doi:10.1038/pr.2018.29 · Cited by 69
Probiotics on Pediatric Functional Gastrointestinal Disorders
Pärtty, A., Rautava, S., & Kalliomäki, M. A. (2018) · Nutrients · doi:10.3390/nu10121836 · Cited by 65
Immune recognition and response to the intestinal microbiome in type 1 diabetes
Paun, A., Yau, C., & Danska, J. S. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.02.004 · Cited by 67
Cesarean or Vaginal Birth Does Not Impact the Longitudinal Development of the Gut Microbiome in a Cohort of Exclusively Preterm Infants
Stewart, C. J., Embleton, N. D., Clements, E., Luna, P. N., Smith, D. P., Fofanova, T. Y., Nelson, A., Taylor, G., Orr, C. H., Petrosino, J. F., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01008 · Cited by 62
Allergy development is associated with consumption of breastmilk with a reduced microbial richness in the first month of life
Dzidic, M., Mira, Á., Artacho, A., Abrahamsson, T., Jenmalm, M. C., & Collado, M. C. (2019) · Pediatric Allergy and Immunology · doi:10.1111/pai.13176 · Cited by 62
Different dietary protein sources influence growth performance, antioxidant capacity, immunity, fecal microbiota and metabolites in weaned piglets
Zhang, L., & Piao, X. (2021) · Animal nutrition · doi:10.1016/j.aninu.2021.06.013 · Cited by 61
Probiotics for treatment and primary prevention of allergic diseases and asthma: looking back and moving forward
West, C. E., Jenmalm, M. C., Kozyrskyj, A. L., & Prescott, S. L. (2016) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2016.1147955 · Cited by 61
Mediation Analysis as a Means of Identifying Dietary Components That Differentially Affect the Fecal Microbiota of Infants Weaned by Modified Baby-Led and Traditional Approaches
Leong, C. S.-F., Haszard, J. J., Lawley, B., Otal, A., Taylor, R. W., Szymlek‐Gay, E. A., Fleming, E., Daniels, L., Fangupo, L. J., Tannock, G. W., et al. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.00914-18 · Cited by 64
Microbiota and Derived Parameters in Fecal Samples of Infants with Non-IgE Cow’s Milk Protein Allergy under a Restricted Diet
Díaz, M., Guadamuro, L., Espinosa‐Martos, I., Mancabelli, L., Jiménez, S., Norniella, C. M., Solís, D. P., Milani, C., Rodríguez, J. M., Ventura, M., et al. (2018) · Nutrients · doi:10.3390/nu10101481 · Cited by 60
Effect of Formula Containing Lactobacillus reuteri DSM 17938 on Fecal Microbiota of Infants Born by Cesarean‐Section
García‐Ródenas, C. L., Lepage, M., Ngom‐Bru, C., Fotiou, A., Papagaroufalis, K., & Berger, B. W. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001198 · Cited by 62
Altering the gut microbiome to potentially modulate behavioral manifestations in autism spectrum disorders: A systematic review
Davies, C., Mishra, D., Eshraghi, R. S., Mittal, J., Sinha, R., Bulut, E., Mittal, R., & Eshraghi, A. A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.001 · Cited by 61
Asthma and the risk of gastrointestinal disorders: a Mendelian randomization study
Freuer, D., Linseisen, J., & Meisinger, C. (2022) · BMC Medicine · doi:10.1186/s12916-022-02283-7 · Cited by 61
Our gut microbiota: a long walk to homeostasis
Dicks, L. M. T., Geldenhuys, J., Mikkelsen, L. S., Brandsborg, E., & Marcotte, H. (2017) · Beneficial Microbes · doi:10.3920/bm2017.0066 · Cited by 61
From Short- to Long-Term Effects of C-Section Delivery on Microbiome Establishment and Host Health
Ríos-Covián, D., Langella, P., & Martín, R. (2021) · Microorganisms · doi:10.3390/microorganisms9102122 · Cited by 63
Immunoglobulin E response in health and disease beyond allergic disorders
Colas, L., Magnan, A., & Brouard, S. (2022) · Allergy · doi:10.1111/all.15230 · Cited by 57
Mode of Delivery and Asthma at School Age in 9 European Birth Cohorts
Rusconi, F., Zugna, D., Annesi‐Maesano, I., Baïz, N., Barros, H., Correia, S., Duijts, L., Forastiere, F., Inskip, H. M., Kelleher, C. C., et al. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx021 · Cited by 57
Characterizing the Composition of the Pediatric Gut Microbiome: A Systematic Review
Deering, K., Devine, A., O’Sullivan, T. A., Lo, J., Boyce, M. C., & Christophersen, C. T. (2019) · Nutrients · doi:10.3390/nu12010016 · Cited by 59
Lactobacillus-derived indole-3-lactic acid ameliorates colitis in cesarean-born offspring via activation of aryl hydrocarbon receptor
Xia, Y., Liu, C., Li, R., Zheng, M., Feng, B., Gao, J., Long, X., Li, L., Li, S., Zuo, X., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108279 · Cited by 60
Mode of Delivery Determines Neonatal Pharyngeal Bacterial Composition and Early Intestinal Colonization
Brumbaugh, D. E., Arruda, J., Robbins, K., Ir, D., Santorico, S. A., Robertson, C. E., & Frank, D. N. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001124 · Cited by 55
Preterm neonatal immunology at the intestinal interface
Belkum, M. V., Alvarez, L. M., & Neu, J. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03316-w · Cited by 59
Association of birth mode of delivery with infant faecal microbiota, potential pathobionts, and short chain fatty acids: a longitudinal study over the first year of life
Mueller, N., Differding, M. K., Østbye, T., Hoyo, C., & Benjamin‐Neelon, S. (2020) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.16633 · Cited by 61
Probiotics Function in Preventing Atopic Dermatitis in Children
Anania, C., Brindisi, G., Martinelli, I., Bonucci, E., D’Orsi, M., Ialongo, S., Nyffenegger, A., Raso, T., Spatuzzo, M., Castro, G. D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105409 · Cited by 63
Perinatal risk factors for type 1 diabetes revisited: a population-based register study
Waernbaum, I., Dahlquist, G. G., & Lind, T. (2019) · Diabetologia · doi:10.1007/s00125-019-4874-5 · Cited by 57
The Pathophysiology of Labor Dystocia: Theme with Variations
Kissler, K. J., & Hurt, K. J. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-01018-6 · Cited by 63
Mucin–Microbiota Interaction During Postnatal Maturation of the Intestinal Ecosystem: Clinical Implications
Rokhsefat, S., Lin, A., & Comelli, E. M. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4032-6 · Cited by 54

Authors: Jakobsson, H. E., Abrahamsson, T. R., Jenmalm, M. C., Harris, K., Quince, C., Jernberg, C., Björkstén, B., Engstrand, L., & Andersson, A. F.
Affiliations: Swedish Institute (SE)
Linköping University (SE)
University of Glasgow (GB)
Örebro University (SE)
Karolinska Institutet (SE)
Science for Life Laboratory (SE)
Corresponding author: Andersson, Anders F
ORCID: Jakobsson, Hedvig E
Abrahamsson, Thomas R
Jenmalm, Maria C
Quince, Christopher
Jernberg, Cecilia
Engstrand, Lars
Andersson, Anders F
Venue: Gut
Publisher: BMJ
Published: 2013-08-07
Volume: 63
Issue: 4
Pages: 559-566
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gutjnl-2012-303249
OpenAlex: W2167562610
Cited by: 1,011
References: 55
Citations by year: 2026: 39 · 2025: 43 · 2024: 59 · 2023: 71 · 2022: 100 · 2021: 121 · 2020: 114 · 2019: 87 · 2018: 100 · 2017: 71 · 2016: 91 · 2015: 66 · 2014: 42 · 2013: 2
FWCI: 29.99
Type: journal article
Language: en
Open access: green
urn.kb.se
Licence: other-oa
Locations: Gut (publishedVersion)
PubMed (publishedVersion)
KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
UEA Digital Repository (University of East Anglia) (submittedVersion)
Funders: Engineering and Physical Sciences Research Council (EP/H003851/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
Keywords: cesarean section, mode of delivery, infant gut microbiota, microbial diversity, Th1/Th2 immune response, chemokines, CXCL10, CXCL11, allergy risk, immune system development, early life
MeSH terms: Age Factors, Cesarean Section, DNA, Bacterial, Feces, Female, Humans, Immunity, Cellular, Infant, Infant, Newborn, Intestines, Male, RNA, Ribosomal, 16S, Th1 Cells, Bacteroidetes, Chemokine CXCL10, Chemokine CXCL11, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks