Cited by 1,011Gut microbiota and healthInfant Nutrition and HealthMaternal and Perinatal Health Interventions

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section

Open access

Jakobsson, Hedvig E, Abrahamsson, Thomas R, Jenmalm, Maria C, Harris, Keith, Quince, Christopher, Jernberg, Cecilia, Björkstén, Bengt, Engstrand, Lars, Andersson, Anders F·2014·Gut

DOI 10.1136/gutjnl-2012-303249

Open this paper in CoChat — free account

Abstract

OBJECTIVE: The early intestinal microbiota exerts important stimuli for immune development, and a reduced microbial exposure as well as caesarean section (CS) has been associated with the development of allergic disease. Here we address how microbiota development in infants is affected by mode of delivery, and relate differences in colonisation patterns to the maturation of a balanced Th1/Th2 immune response. DESIGN: The postnatal intestinal colonisation pattern was investigated in 24 infants, born vaginally (15) or by CS (nine). The intestinal microbiota were characterised using pyrosequencing of 16S rRNA genes at 1 week and 1, 3, 6, 12 and 24 months after birth. Venous blood levels of Th1- and Th2-associated chemokines were measured at 6, 12 and 24 months. RESULTS: Infants born through CS had lower total microbiota diversity during the first 2 years of life. CS delivered infants also had a lower abundance and diversity of the Bacteroidetes phylum and were less often colonised with the Bacteroidetes phylum. Infants born through CS had significantly lower levels of the Th1-associated chemokines CXCL10 and CXCL11 in blood. CONCLUSIONS: CS was associated with a lower total microbial diversity, delayed colonisation of the Bacteroidetes phylum and reduced Th1 responses during the first 2 years of life.

Integrity signals

Registry

Crossref · 10.1136/gutjnl-2012-303249

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies.
Klindworth, A., Pruesse, E., Schweer, T., Peplies, J., Quast, C., Horn, M., & Glöckner, F. O. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks808 · Cited by 8,850
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
The measurement of diversity in different types of biological collections
Pielou, E. C. (1966) · Journal of Theoretical Biology · doi:10.1016/0022-5193(66)90013-0 · Cited by 6,021
Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774
Nonparametric estimation of the number of classes in a population
Chao, A. (1984) · Scandinavian Journal of Statistics · Cited by 4,263
Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Transitions in bacterial communities along the 2000 km salinity gradient of the Baltic Sea
Herlemann, D. P. R., Labrenz, M., Jürgens, K., Bertilsson, S., Waniek, J. J., & Andersson, A. F. (2011) · The ISME Journal · doi:10.1038/ismej.2011.41 · Cited by 2,885

Show all 55 references

Sorted by citations

The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Gut microbiota in human metabolic health and disease
Fan, Y., & Pedersen, O. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0433-9 · Cited by 4,724
Proteobacteria: Microbial signature of dysbiosis in gut microbiota
Shin, N.-R., Whon, T. W., & Bae, J.-W. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.06.011 · Cited by 3,954
Introduction to the human gut microbiota
Thursby, E., & Juge, N. (2017) · Biochemical Journal · doi:10.1042/bcj20160510 · Cited by 3,600
The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950
Antibiotics, birth mode, and diet shape microbiome maturation during early life
Bokulich, N. A., Chung, J., Battaglia, T., Henderson, N., Jay, M., Li, H., D. Lieber, A., Wu, F., Perez-Perez, G. I., Chen, Y., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7121 · Cited by 1,469
Short-term and long-term effects of caesarean section on the health of women and children
Sandall, J., Tribe, R. M., Avery, L., Mola, G., Visser, G. H., Homer, C. S., Gibbons, D., Kelly, N. M., Kennedy, H. P., Kidanto, H., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31930-5 · Cited by 1,394
The composition of the gut microbiota throughout life, with an emphasis on early life
Rodríguez, J. M., Murphy, K., Stanton, C., Ross, R. P., Kober, O. I., Juge, N., Avershina, E., Rudi, K., Narbad, A., Jenmalm, M. C., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26050 · Cited by 1,414
The microbiome in early life: Implications for health outcomes
Tamburini, S., Shen, N., Wu, H. C., & Clemente, J. C. (2016) · Nature Medicine · doi:10.1038/nm.4142 · Cited by 1,213
Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth
Shao, Y., Forster, S. C., Tsaliki, E., Vervier, K., Strang, A., Simpson, N., Kumar, N., Stares, M. D., Rodger, A., Brocklehurst, P., et al. (2019) · Nature · doi:10.1038/s41586-019-1560-1 · Cited by 1,088
Microbiota and neurodevelopmental windows: implications for brain disorders
Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089
Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability
Yassour, M., Vatanen, T., Siljander, H., Hämäläinen, A.-M., Härkönen, T., Ryhänen, S. J., Franzosa, E. A., Vlamakis, H., Huttenhower, C., Gevers, D., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad0917 · Cited by 1,043
The Intestinal Microbiome in Early Life: Health and Disease
Arrieta, M.-C., Stiemsma, L. T., Amenyogbe, N., Brown, E. M., & Finlay, B. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00427 · Cited by 1,024
Microbial genes and pathways in inflammatory bowel disease
Schirmer, M., Garner, A., Vlamakis, H. C., & Xavier, R. J. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0213-6 · Cited by 979
The gut microbiome: Relationships with disease and opportunities for therapy
Durack, J., & Lynch, S. V. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180448 · Cited by 979
The infant microbiome development: Mom matters
Mueller, N. T., Bakacs, E., Combellick, J., Grigoryan, Z., & Dominguez-Bello, M. G. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.12.002 · Cited by 943
Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body
Cristofori, F., Dargenio, V. N., Dargenio, C., Miniello, V. L., Barone, M., & Francavilla, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.578386 · Cited by 991
Microbiota-Brain-Gut Axis and Neurodegenerative Diseases
Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804
The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review
Rutayisire, E., Huang, K., Liu, Y., & Tao, F. (2016) · BMC Gastroenterology · doi:10.1186/s12876-016-0498-0 · Cited by 708
The Gut–Lung Axis in Respiratory Disease
Marsland, B. J., Trompette, A., & Gollwitzer, E. S. (2015) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201503-133aw · Cited by 658
Microbial Changes during Pregnancy, Birth, and Infancy
Nuriel‐Ohayon, M., Neuman, H., & Koren, O. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01031 · Cited by 647
Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study
Azad, M. B., Konya, T., Persaud, R. R., Guttman, D. S., Chari, R., Field, C. J., Sears, M., Mandhane, P., Turvey, S., Subbarao, P., et al. (2015) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.13601 · Cited by 619
Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?
Mosca, A., Leclerc, M., & Hugot, J. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00455 · Cited by 612
Normalization of host intestinal mucus layers requires long-term microbial colonization
Johansson, M. E. V., Jakobsson, H. E., Holmén-Larsson, J., Schütte, A., Ermund, A., Rodríguez-Piñeiro, A. M., Arike, L., Wising, C., Svensson, F., Bäckhed, F., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.10.007 · Cited by 549
The Gut–Brain Axis and the Microbiome: Mechanisms and Clinical Implications
Osadchiy, V., Martin, C. R., & Mayer, E. A. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.10.002 · Cited by 555
Gut microbiota, obesity and diabetes
Patterson, E., Ryan, P. M., Cryan, J. F., Dinan, T. G., Ross, R. P., Fitzgerald, G. F., & Stanton, C. (2016) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2015-133285 · Cited by 552
Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study
El-Salhy, M., Hatlebakk, J. G., Gilja, O. H., Bråthen Kristoffersen, A., & Hausken, T. (2020) · Gut · doi:10.1136/gutjnl-2019-319630 · Cited by 498
Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity
Mueller, N. T., Whyatt, R. M., Hoepner, L., Oberfield, S. E., Domínguez-Bello, M. G., Widen, E. M., Hassoun, A. A., Perera, F. P., & Rundle, A. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.180 · Cited by 501
DegePrime, a Program for Degenerate Primer Design for Broad-Taxonomic-Range PCR in Microbial Ecology Studies
Hugerth, L. W., Wefer, H. A., Lundin, S., Jakobsson, H. E., Lindberg, M., Rodin, S., Engstrand, L. G., & Andersson, A. F. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.01403-14 · Cited by 481
Infant gut microbiota and food sensitization: associations in the first year of life
Azad, M. B., Konya, T., Guttman, D. S., Field, C. J., Sears, M. R., HayGlass, K. T., Mandhane, P. J., Turvey, S. E., Subbarao, P., Becker, A. B., et al. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12487 · Cited by 517
Developmental trajectory of the healthy human gut microbiota during the first 5 years of life
Roswall, J., Olsson, L. M., Kovatcheva‐Datchary, P., Nilsson, S., Tremaroli, V., Simon, M., Kiilerich, P., Akrami, R., Kramer, M. M., Uhlén, M., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.02.021 · Cited by 487
Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life
Yassour, M., Jason, E., Hogstrom, L. J., Arthur, T. D., Tripathi, S., Siljander, H., Selvenius, J., Oikarinen, S., Hyöty, H., Virtanen, S. M., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.06.007 · Cited by 455
Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents
Gilbert, S. F., Bosch, T. C. G., & Ledón‐Rettig, C. C. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3982 · Cited by 461
Early-Life Events, Including Mode of Delivery and Type of Feeding, Siblings and Gender, Shape the Developing Gut Microbiota
Martín, R., Makino, H., Cetinyurek‐Yavuz, A., Amor, K. B., Roelofs, M., Ishikawa, E., Kubota, H., Willemsen‐Swinkels, S. H. N., Sakai, T., Oishi, K., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158498 · Cited by 462
Intestinal Microbiota Development in Preterm Neonates and Effect of Perinatal Antibiotics
Arboleya, S., Sánchez, B., Milani, C., Duranti, S., Sánchez, G. S., Fernández, N., Reyes‐Gavilán, C. G. D. L., Ventura, M., Margollés, A., & Gueimonde, M. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.09.041 · Cited by 434
The role of the intestinal microbiota in type 1 diabetes mellitus
Knip, M., & Siljander, H. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.218 · Cited by 444
Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction
Bouter, K. E. C., van Raalte, D. H., Groen, A. K., & Nieuwdorp, M. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.12.048 · Cited by 443
Role of priority effects in the early-life assembly of the gut microbiota
Sprockett, D., Fukami, T., & Relman, D. A. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.173 · Cited by 419
Gut Microbiome
Cresci, G., & Bawden, E. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615609899 · Cited by 459
Intestinal flora and disease mutually shape the regional immune system in the intestinal tract
Zhou, B., Yuan, Y., Zhang, S., Guo, C., Li, X., Li, G., Xiong, W., & Zeng, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00575 · Cited by 396
The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems
Flandroy, L., Poutahidis, T., Berg, G., Clarke, G. A., Dao, M. C., Decaestecker, E., Furman, E., Haahtela, T., Massart, S., Plovier, H., et al. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.01.288 · Cited by 417
Diet as a Trigger or Therapy for Inflammatory Bowel Diseases
Lewis, J. D., & Abreu, M. T. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.019 · Cited by 396
Altered Fecal Microbiota Composition Associated with Food Allergy in Infants
Ling, Z., Li, Z., Liu, X., Cheng, Y., Luo, Y., Tong, X., Li, Y., Wang, Y., Sun, J., Li, L., et al. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00003-14 · Cited by 385
Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study
Korpela, K., Helve, O., Kolho, K.-L., Saisto, T., Skogberg, K., Dikareva, E., Stefanović, V., Salonen, A., Andersson, S., & de Vos, W. M. (2020) · Cell · doi:10.1016/j.cell.2020.08.047 · Cited by 358
Why Is Initial Bacterial Colonization of the Intestine Important to Infants' and Children's Health?
Houghteling, P. D., & Walker, W. A. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000597 · Cited by 353
Effects of Infant Formula With Human Milk Oligosaccharides on Growth and Morbidity
Puccio, G., Alliet, P., Cajozzo, C., Janssens, E., Corsello, G., Sprenger, N., Wernimont, S. M., Egli, D., Gosoniu, L. M., & Steenhout, P. G. (2017) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001520 · Cited by 350
Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year
Kennedy, E. A., Connolly, J., Hourihane, J. O., Fallon, P. G., McLean, W. H. I., Murray, D. M., Jo, J., Segre, J. A., Kong, H. H., & Irvine, A. D. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.07.029 · Cited by 359
Rebuilding the Gut Microbiota Ecosystem
Gagliardi, A., Totino, V., Cacciotti, F., Iebba, V., Neroni, B., Bonfiglio, G., Trancassini, M., Passariello, C., Pantanella, F., & Schippa, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15081679 · Cited by 340
The Human Neonatal Gut Microbiome: A Brief Review
Gritz, E. C., & Bhandari, V. (2015) · Frontiers in Pediatrics · doi:10.3389/fped.2015.00017 · Cited by 323
Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential
Wampach, L., Heintz-Buschart, A., Fritz, J. V., Ramiro-Garcia, J., Habier, J., Herold, M., Narayanasamy, S., Kaysen, A., Hogan, A. H., Bindl, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07631-x · Cited by 292
The Elevated Rate of Cesarean Section and Its Contribution to Non-Communicable Chronic Diseases in Latin America: The Growing Involvement of the Microbiota
Magne, F., Puchi, A., Carvajal, B., & Gotteland, M. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00192 · Cited by 309
The neuroimmune axis of Alzheimer’s disease
Jorfi, M., Maaser‐Hecker, A., & Tanzi, R. E. (2023) · Genome Medicine · doi:10.1186/s13073-023-01155-w · Cited by 313
Establishing What Constitutes a Healthy Human Gut Microbiome: State of the Science, Regulatory Considerations, and Future Directions
McBurney, M. I., Davis, C. D., Fraser, C. M., Schneeman, B. O., Huttenhower, C., Verbeke, K., Walter, J., & Latulippe, M. E. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz154 · Cited by 296
The Commensal Microbiota and Viral Infection: A Comprehensive Review
Li, N., Ma, W., Pang, M., Fan, Q., & Hua, J.-L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01551 · Cited by 290
Association of Cesarean Delivery and Formula Supplementation With the Intestinal Microbiome of 6-Week-Old Infants
Madan, J. C., Hoen, A. G., Lundgren, S., Farzan, S. F., Cottingham, K. L., Morrison, H. G., Sogin, M. L., Li, H., Moore, J. H., & Karagas, M. R. (2016) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2015.3732 · Cited by 274
The gut microbiota and inflammatory noncommunicable diseases: Associations and potentials for gut microbiota therapies
West, C. E., Renz, H. E., Jenmalm, M. C., Kozyrskyj, A. L., Allen, K. J., Vuillermin, P., Prescott, S. L., Mackay, C. R., Salminen, S., Wong, G., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.012 · Cited by 288
Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities
Slyepchenko, A., Maes, M., Jacka, F. N., Köhler, C. A., Barichello, T., McIntyre, R. S., Berk, M., Grande, I., Foster, J. A., Vieta, E., et al. (2017) · Psychotherapy and Psychosomatics · doi:10.1159/000448957 · Cited by 278
Oral microbiome development during childhood: an ecological succession influenced by postnatal factors and associated with tooth decay
Dzidic, M., Collado, M. C., Abrahamsson, T., Artacho, A., Stensson, M., Jenmalm, M. C., & Mira, A. (2018) · The ISME Journal · doi:10.1038/s41396-018-0204-z · Cited by 279
Development of Upper Respiratory Tract Microbiota in Infancy is Affected by Mode of Delivery
Bosch, A. A. T. M., Levin, E., van Houten, M. A., Hasrat, R., Kalkman, G., Biesbroek, G., de Steenhuijsen Piters, W. A. A., de Groot, P.-K. C. M., Pernet, P., Keijser, B. J. F., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.05.031 · Cited by 276
Association between caesarean section and childhood obesity: a systematic review and meta‐analysis
Kuhle, S., Tong, O. S., & Woolcott, C. G. (2015) · Obesity Reviews · doi:10.1111/obr.12267 · Cited by 285
Colonization and Succession within the Human Gut Microbiome by Archaea, Bacteria, and Microeukaryotes during the First Year of Life
Wampach, L., Heintz‐Buschart, A., Hogan, A. H., Muller, E. E. L., Narayanasamy, S., Laczny, C. C., Hugerth, L. W., Bindl, L., Bottu, J., Andersson, A. F., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00738 · Cited by 270
Adaptive immune education by gut microbiota antigens
Zhao, Q. S., & Elson, C. O. (2018) · Immunology · doi:10.1111/imm.12896 · Cited by 288
Temporal development of the infant gut microbiome
Moore, R. E., & Townsend, S. D. (2019) · Open Biology · doi:10.1098/rsob.190128 · Cited by 272
How biological sex of the host shapes its gut microbiota
Valeri, F., & Endres, K. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100912 · Cited by 278
Characterisation of Early-Life Fecal Microbiota in Susceptible and Healthy Pigs to Post-Weaning Diarrhoea
Dou, S., Gadonna‐Widehem, P., Rome, V., Hamoudi, D., Rhazi, L., Lakhal, L., Larcher, T., Bahi-Jaber, N., Pinon-Quintana, A., Guyonvarch, A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169851 · Cited by 285
The gut microbiota: A treasure for human health
Li, D., Wang, P., Wang, P., Hu, X., & Chen, F. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.08.003 · Cited by 271
The Role of Microbiota in Infant Health: From Early Life to Adulthood
Yao, Y., Cai, X. T., Ye, Y., Wang, F., Chen, F., & Zheng, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708472 · Cited by 271
Infant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity
Laursen, M. F., Andersen, L. B. B., Michaelsen, K. F., Mølgaard, C., Trolle, E., Bahl, M. I., & Licht, T. R. (2016) · mSphere · doi:10.1128/msphere.00069-15 · Cited by 252
Association between the intestinal microbiota and allergic sensitization, eczema, and asthma: A systematic review
Zimmermann, P., Messina, N. L., Mohn, W. W., Finlay, B. B., & Curtis, N. C. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.09.025 · Cited by 252
Oral microbiota and cancer development
Tuominen, H., & Rautava, J. (2021) · Pathobiology · doi:10.1159/000510979 · Cited by 238
Skin Colonization by Staphylococcus aureus Precedes the Clinical Diagnosis of Atopic Dermatitis in Infancy
Meylan, P., Lang, C., Mermoud, S., Johannsen, A., Norrenberg, S., Hohl, D., Vial, Y., Prod’hom, G., Greub, G., Kypriotou, M., et al. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.07.834 · Cited by 251
Evolution, human-microbe interactions, and life history plasticity
Rook, G., Bäckhed, F., Levin, B. R., McFall-Ngai, M. J., & McLean, A. R. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30566-4 · Cited by 246
Gut Microbiome Developmental Patterns in Early Life of Preterm Infants: Impacts of Feeding and Gender
Cong, X. S., Xu, W., Janton, S., Henderson, W. A., Matson, A. P., McGrath, J. M., Maas, K. R., & Graf, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152751 · Cited by 245
Factors Affecting Gastrointestinal Microbiome Development in Neonates
Chong, C. Y. L., Bloomfield, F. H., & O'Sullivan, J. M. (2018) · Nutrients · doi:10.3390/nu10030274 · Cited by 261
Systematic Review of the Human Milk Microbiota
Fitzstevens, J. L., Smith, K. C., Hagadorn, J. I., Caimano, M. J., Matson, A. P., & Brownell, E. (2016) · Nutrition in Clinical Practice · doi:10.1177/0884533616670150 · Cited by 246
From conception to infancy — early risk factors for childhood obesity
Larqué, E., Labayen, I., Flodmark, C., Lissau, I., Czernin, S., Moreno, L. A., Pietrobelli, A., & Widhalm, K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0219-1 · Cited by 267
Maternal vertical transmission affecting early-life microbiota development
Wang, S., Ryan, C. A., Boyaval, P., Dempsey, E. M., Ross, R. P., & Stanton, C. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2019.07.010 · Cited by 243
Delivery Mode Affects Stability of Early Infant Gut Microbiota
Mitchell, C. M., Mazzoni, C., Hogstrom, L. J., Bryant, A., Bergerat, A., Cher, A., Pochan, S., Herman, P., Carrigan, M., Sharp, K., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100156 · Cited by 252
Impact of intrapartum antimicrobial prophylaxis upon the intestinal microbiota and the prevalence of antibiotic resistance genes in vaginally delivered full-term neonates
Nogacka, A. M., Salazar, N., Suárez, M., Milani, C., Arboleya, S., Sánchez, G. S., Fernández, N., Alaez, L., Hernández‐Barranco, A. M., Reyes‐Gavilán, C. G. D. L., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0313-3 · Cited by 237
The microbiota in inflammatory bowel disease: Current and therapeutic insights
Lane, E. R., Zisman, T., & Suskind, D. (2017) · Journal of Inflammation Research · doi:10.2147/jir.s116088 · Cited by 226
The human gut microbiome in health: Establishment and resilience of microbiota over a lifetime
Greenhalgh, K., Meyer, K. M., Aagaard, K. M., & Wilmes, P. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13318 · Cited by 218
The Connection Between Physical Exercise and Gut Microbiota: Implications for Competitive Sports Athletes
Wegierska, A. E., Charitos, I. A., Topi, S., Potenza, M. A., Montagnani, M., & Santacroce, L. (2022) · Sports Medicine · doi:10.1007/s40279-022-01696-x · Cited by 250
The gut microbiota and its role in the development of allergic disease: A wider perspective
West, C. E., Jenmalm, M. C., & Prescott, S. L. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12332 · Cited by 223
Self-citation
External Influence of Early Childhood Establishment of Gut Microbiota and Subsequent Health Implications
Munyaka, P. M., Khafipour, E., & Ghia, J. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00109 · Cited by 223
Maternal influences on fetal microbial colonization and immune development
Romano-Keeler, J., & Weitkamp, J.-H. (2014) · Pediatric Research · doi:10.1038/pr.2014.163 · Cited by 211
Maternal Microbiota, Early Life Colonization and Breast Milk Drive Immune Development in the Newborn
Kalbermatter, C., Trigo, N. F., Christensen, S., & Ganal-Vonarburg, S. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.683022 · Cited by 220
Early life colonization of the human gut: microbes matter everywhere
Korpela, K., & de Vos, W. M. (2018) · Current Opinion in Microbiology · doi:10.1016/j.mib.2018.06.003 · Cited by 211
Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?
O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.068 · Cited by 203
Breast Milk Microbiota Is Shaped by Mode of Delivery and Intrapartum Antibiotic Exposure
Hermansson, H., Kumar, H., Collado, M. C., Salminen, S., Isolauri, E., & Rautava, S. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00004 · Cited by 218
Allergy associations with the adult fecal microbiota: Analysis of the American Gut Project
Hua, X., Goedert, J. J., Pu, A., Yu, G., & Shi, J. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.11.038 · Cited by 207
Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease
Codagnone, M. G., Spichak, S., O’Mahony, S. M., O’Leary, O. F., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.06.014 · Cited by 198
Functional Foods, Nutraceuticals and Probiotics: A Focus on Human Health
Damián, M. R., Cortes‐Perez, N. G., Quintana, E. T., Ortiz‐Moreno, A., Garfias-Noguez, C., Cruceño-Casarrubias, C. E., Pardo, M. E. S., & Bermúdez‐Humarán, L. G. (2022) · Microorganisms · doi:10.3390/microorganisms10051065 · Cited by 223
The hygiene hypothesis: current perspectives and future therapies
Stiemsma, L. T., Reynolds, L. A., Turvey, S. E., & Finlay, B. B. (2015) · ImmunoTargets and Therapy · doi:10.2147/itt.s61528 · Cited by 201
Neonatal gut microbiome and immunity
Sanidad, K. Z., & Zeng, M. Y. (2020) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.05.011 · Cited by 205
Gastrointestinal and hepatic mechanisms limiting entry and dissemination of lipopolysaccharide into the systemic circulation
Guerville, M., & Boudry, G. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2016 · Cited by 195
Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis
Grech, A. M., Collins, C. E., Holmes, A. J., Lal, R., Duncanson, K., Taylor, R., & Gordon, A. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1897210 · Cited by 198
Rapidly expanding knowledge on the role of the gut microbiome in health and disease
Cénit, M. C., Matzaraki, V., Tigchelaar, E. F., & Zhernakova, A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.023 · Cited by 197
Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases
Battistini, C., Ballan, R., Herkenhoff, M. E., Saad, S. M. I., & Sun, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010362 · Cited by 196
Priming for Life: Early Life Nutrition and the Microbiota-Gut-Brain Axis
Ratsika, A., Codagnone, M. G., O’Mahony, S. M., Stanton, C., & Cryan, J. F. (2021) · Nutrients · doi:10.3390/nu13020423 · Cited by 194
Patterns of Early-Life Gut Microbial Colonization during Human Immune Development: An Ecological Perspective
Laforest‐Lapointe, I., & Arrieta, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00788 · Cited by 195

Authors: Jakobsson, H. E., Abrahamsson, T. R., Jenmalm, M. C., Harris, K., Quince, C., Jernberg, C., Björkstén, B., Engstrand, L., & Andersson, A. F.
Affiliations: Swedish Institute (SE)
Linköping University (SE)
University of Glasgow (GB)
Örebro University (SE)
Karolinska Institutet (SE)
Science for Life Laboratory (SE)
Corresponding author: Andersson, Anders F
ORCID: Jakobsson, Hedvig E
Abrahamsson, Thomas R
Jenmalm, Maria C
Quince, Christopher
Jernberg, Cecilia
Engstrand, Lars
Andersson, Anders F
Venue: Gut
Publisher: BMJ
Published: 2013-08-07
Volume: 63
Issue: 4
Pages: 559-566
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gutjnl-2012-303249
OpenAlex: W2167562610
Cited by: 1,011
References: 55
Citations by year: 2026: 39 · 2025: 43 · 2024: 59 · 2023: 71 · 2022: 100 · 2021: 121 · 2020: 114 · 2019: 87 · 2018: 100 · 2017: 71 · 2016: 91 · 2015: 66 · 2014: 42 · 2013: 2
FWCI: 29.99
Type: journal article
Language: en
Open access: green
urn.kb.se
Licence: other-oa
Locations: Gut (publishedVersion)
PubMed (publishedVersion)
KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
UEA Digital Repository (University of East Anglia) (submittedVersion)
Funders: Engineering and Physical Sciences Research Council (EP/H003851/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
Keywords: cesarean section, mode of delivery, infant gut microbiota, microbial diversity, Th1/Th2 immune response, chemokines, CXCL10, CXCL11, allergy risk, immune system development, early life
MeSH terms: Age Factors, Cesarean Section, DNA, Bacterial, Feces, Female, Humans, Immunity, Cellular, Infant, Infant, Newborn, Intestines, Male, RNA, Ribosomal, 16S, Th1 Cells, Bacteroidetes, Chemokine CXCL10, Chemokine CXCL11, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks