The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice
Abstract
Objective: The differential role of the IL-1 agonists, IL-1α, which is mainly cell-associated versus IL-1β, which is mostly secreted, was studied in colon inflammation. Design: Dextran sodium sulfate (DSS) colitis was induced in mice globally deficient in either IL-1α or IL-1β, and in wild-type mice, or in mice with conditional deletion of IL-1α in intestinal epithelial cells (IECs). Bone marrow transplantation experiments were performed to assess the role of IL-1α or IL-1β of myeloid versus colon non-hematopoietic cells in inflammation and repair in acute colitis. Results: IL-1α released from damaged IECs acts as an alarmin by initiating and propagating colon inflammation, as IL-1α deficient mice exhibited mild disease symptoms with improved recovery. IL-1β is involved in repair of IECs and reconstitution of the epithelial barrier during the resolution of colitis; its deficiency correlates with disease exacerbation. Neutralisation of IL-1α in control mice during acute colitis led to alleviation of clinical and histological manifestations, whereas treatment with rIL-1Ra or anti-IL-1β antibodies was not effective. Repair after colitis correlated with accumulation of CD8 and regulatory T cells in damaged crypts. Conclusions: The role of IL-1α and IL-1β differs in DSS-induced colitis in that IL-1α, mainly of colon epithelial cells is inflammatory, whereas IL-1β, mainly of myeloid cell origin, promotes healing and repair. Given the dissimilar functions of each IL-1 agonistic molecule, an IL-1 receptor blockade would not be as therapeutically effective as specific neutralising of IL-1α, which leaves IL-1β function intact.
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Cites
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Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
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The interleukin-1 family: back to the future
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Overview of the IL ‐1 family in innate inflammation and acquired immunity
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Self-citationInterleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity
Mantovani, A., Dinarello, C. A., Molgora, M., & Garlanda, C. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.012 · Cited by 1,046
Self-citationImmunological aspects of intestinal mucus and mucins
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Resolution of Inflammation: What Controls Its Onset?
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Metadata
- Authors
- Bersudsky, M., Luski, L., Fishman, D., White, R. M., Ziv-Sokolovskaya, N., Dotan, S., Rider, P., Kaplanov, I., Aychek, T., Dinarello, C. A., Apte, R. N., & Voronov, E.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2013-06-21
- Volume
- 63
- Issue
- 4
- Pages
- 598-609
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2105458866
- Cited by
- 252
- References
- 10
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bersudsky, M., Luski, L., Fishman, D., White, R. M., Ziv-Sokolovskaya, N., Dotan, S., Rider, P., Kaplanov, I., Aychek, T., Dinarello, C. A., Apte, R. N., & Voronov, E. (2014). Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice. Gut. https://doi.org/10.1136/gutjnl-2012-303329
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