Resolution of Inflammation: What Controls Its Onset?
Open accessAbstract
An effective resolution program may be able to prevent the progression from non-resolving acute inflammation to persistent chronic inflammation. It has now become evident that coordinated resolution programs initiate shortly after inflammatory responses begin. In this context, several mechanisms provide the fine-tuning of inflammation and create a favorable environment for the resolution phase to take place and for homeostasis to return. In this review, we focus on the events required for an effective transition from the proinflammatory phase to the onset and establishment of resolution. We suggest that several mediators that promote the inflammatory phase of inflammation can simultaneously initiate a program for active resolution. Indeed, several events enact a decrease in the local chemokine concentration, a reduction which is essential to inhibit further infiltration of neutrophils into the tissue. Interestingly, although neutrophils are cells that characteristically participate in the active phase of inflammation, they also contribute to the onset of resolution. Further understanding of the molecular mechanisms that initiate resolution may be instrumental to develop pro-resolution strategies to treat complex chronic inflammatory diseases, in humans. The efforts to develop strategies based on resolution of inflammation have shaped a new area of pharmacology referred to as "resolution pharmacology."
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Innate immunity has a central role in inflammation and coordinates its initiation, propagation, and resolution.
“Innate immunity has a central role in the inflammatory process and coordinates the three stages of inflammation: initiation, propagation and resolution195.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [195]
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- Authors
- Sugimoto, M. A., Sousa, L. P., Pinho, V., Perretti, M., & Teixeira, M. M.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Queen Mary University of London (GB)
- Corresponding author
- Perretti, Mauro
- Teixeira, Mauro M.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2016-04-26
- Volume
- 7
- Pages
- 160-160
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC4845539
- OpenAlex
- W2344418141
- Cited by
- 638
- References
- 254
- Citations by year
- 2026: 43 · 2025: 50 · 2024: 78 · 2023: 86 · 2022: 99 · 2021: 100 · 2020: 51 · 2019: 57 · 2018: 35 · 2017: 32 · 2016: 7
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
- Funders
- Seventh Framework Programme (FP7-2007-2013)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais
- Wellcome Trust (086867/Z/08)
- Medical Research Council (MR/K013068/1)
- William Harvey Research Foundation
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- inflammation resolution, chronic inflammation, acute inflammation, chemokines, neutrophil infiltration, homeostasis
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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