Cited by 638Fatty Acid Research and HealthInflammatory mediators and NSAID effectsPhagocytosis and Immune Regulation

Resolution of Inflammation: What Controls Its Onset?

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Sugimoto, Michelle A., Sousa, Lirlândia P., Pinho, Vanessa, Perretti, Mauro, Teixeira, Mauro M.·2016·Frontiers in Immunology

Abstract

An effective resolution program may be able to prevent the progression from non-resolving acute inflammation to persistent chronic inflammation. It has now become evident that coordinated resolution programs initiate shortly after inflammatory responses begin. In this context, several mechanisms provide the fine-tuning of inflammation and create a favorable environment for the resolution phase to take place and for homeostasis to return. In this review, we focus on the events required for an effective transition from the proinflammatory phase to the onset and establishment of resolution. We suggest that several mediators that promote the inflammatory phase of inflammation can simultaneously initiate a program for active resolution. Indeed, several events enact a decrease in the local chemokine concentration, a reduction which is essential to inhibit further infiltration of neutrophils into the tissue. Interestingly, although neutrophils are cells that characteristically participate in the active phase of inflammation, they also contribute to the onset of resolution. Further understanding of the molecular mechanisms that initiate resolution may be instrumental to develop pro-resolution strategies to treat complex chronic inflammatory diseases, in humans. The efforts to develop strategies based on resolution of inflammation have shaped a new area of pharmacology referred to as "resolution pharmacology."

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Crossref · 10.3389/fimmu.2016.00160

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  • Innate immunity has a central role in inflammation and coordinates its initiation, propagation, and resolution.

    “Innate immunity has a central role in the inflammatory process and coordinates the three stages of inflammation: initiation, propagation and resolution195.”

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Authors
Sugimoto, M. A., Sousa, L. P., Pinho, V., Perretti, M., & Teixeira, M. M.
Affiliations
  • Universidade Federal de Minas Gerais (BR)
  • Queen Mary University of London (GB)
Corresponding author
  • Perretti, Mauro
  • Teixeira, Mauro M.
Venue
Frontiers in Immunology
Published
2016-04-26
Volume
7
Pages
160-160
ISSN
1664-3224 (ISSN-L)
OpenAlex
W2344418141
Cited by
638
References
254
Citations by year
2026: 43 · 2025: 50 · 2024: 78 · 2023: 86 · 2022: 99 · 2021: 100 · 2020: 51 · 2019: 57 · 2018: 35 · 2017: 32 · 2016: 7
FWCI
5.87
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
Funders
  • Seventh Framework Programme (FP7-2007-2013)
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Fundação de Amparo à Pesquisa do Estado de Minas Gerais
  • Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais
  • Wellcome Trust (086867/Z/08)
  • Medical Research Council (MR/K013068/1)
  • William Harvey Research Foundation
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords
inflammation resolution, chronic inflammation, acute inflammation, chemokines, neutrophil infiltration, homeostasis

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