Immunological aspects of intestinal mucus and mucins

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204 · see citing works

Changes of Intestinal Functions in Liver Cirrhosis

Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works

Interleukin-10-deficient mice develop chronic enterocolitis

Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248 · see citing works

Evolution of mammals and their gut microbes

Ley, R. E., Hamady, M., Lozupone, C., Turnbaugh, P. J., Ramey, R. R., Bircher, J. S., Schlegel, M. L., Tucker, T. A., Schrenzel, M. D., Knight, R., et al. (2008) · Science · doi:10.1126/science.1155725 · Cited by 3,747 · see citing works

Review article: the role of butyrate on colonic function

HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03562.x · Cited by 2,721 · see citing works

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200 · see citing works

Diet-induced extinctions in the gut microbiota compound over generations

Sonnenburg, E. D., Smits, S. A., Tikhonov, M., Higginbottom, S. K., Wingreen, N. S., & Sonnenburg, J. L. (2016) · Nature · doi:10.1038/nature16504 · Cited by 1,730 · see citing works

Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection

Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684 · see citing works

Immune adaptations that maintain homeostasis with the intestinal microbiota

Hooper, L. V., & Macpherson, A. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2710 · Cited by 1,455 · see citing works

Symbiotic bacteria direct expression of an intestinal bactericidal lectin

Cash, H. L., Whitham, C. V., Behrendt, C. L., & Hooper, L. V. (2006) · Science · doi:10.1126/science.1127119 · Cited by 1,432 · see citing works

The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K., & Hooper, L. V. (2011) · Science · doi:10.1126/science.1209791 · Cited by 1,412 · see citing works

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

Bevins, C. L., & Salzman, N. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2546 · Cited by 1,238 · see citing works

Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit

von Moltke, J., Ji, M., Liang, H.-E., & Locksley, R. M. (2016) · Nature · doi:10.1038/nature16161 · Cited by 1,230 · see citing works

Glycan foraging in vivo by an intestine-adapted bacterial symbiont

Sonnenburg, J. L., Xu, J., Leip, D. D., Chen, C.-H., Westover, B. P., Weatherford, J., Buhler, J. D., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1109051 · Cited by 1,184 · see citing works

The immune geography of IgA induction and function

Macpherson, A. J., McCoy, K. D., Johansen, F.-E., & Brandtzaeg, P. (2007) · Mucosal Immunology · doi:10.1038/mi.2007.6 · Cited by 1,047 · see citing works

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmén-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjövall, H., et al. (2014) · Gut · doi:10.1136/gutjnl-2012-303207 · Cited by 1,004 · see citing works

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

Mcdole, J. R., Wheeler, L. W., McDonald, K. G., Wang, B., Konjufca, V. H., Knoop, K. A., Newberry, R. D., & Miller, M. J. (2012) · Nature · doi:10.1038/nature10863 · Cited by 976 · see citing works

Reciprocal Gut Microbiota Transplants from Zebrafish and Mice to Germ-free Recipients Reveal Host Habitat Selection

Rawls, J. F., Mahowald, M. A., Ley, R. E., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.08.043 · Cited by 962 · see citing works

Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling

Levy, M., Thaiss, C. A., Zeevi, D., Dohnalová, L., Zilberman-Schapira, G., Mahdi, J. A., David, E., Savidor, A., Korem, T., Herzig, Y., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.048 · Cited by 960 · see citing works

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

Gerbe, F., Sidot, E., Smyth, D. J., Ohmoto, M., Matsumoto, I., Dardalhon, V., Cesses, P., Garnier, L., Pouzolles, M., Brulin, B., et al. (2016) · Nature · doi:10.1038/nature16527 · Cited by 944 · see citing works

Bacteriophage adhering to mucus provide a non–host-derived immunity

Barr, J. J., Auro, R., Furlan, M., Whiteson, K., Erb, M. L., Pogliano, J., Stotland, A. B., Wolkowicz, R., Cutting, A. S., Doran, K. S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305923110 · Cited by 942 · see citing works

Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2

Velcich, A., Yang, W., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. (2002) · Science · doi:10.1126/science.1069094 · Cited by 936 · see citing works

Bacteroides thetaiotaomicron and Faecalibacterium prausnitziiinfluence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent

Wrzosek, L., Miquel, S., Noordine, M.-L., Bouet, S., Curt, M. J.-C., Robert, V., Philippe, C., Bridonneau, C., Cherbuy, C., Masselot, C. R., et al. (2013) · BMC Biology · doi:10.1186/1741-7007-11-61 · Cited by 807 · see citing works

Ligands for L-Selectin: Homing, Inflammation, and Beyond

Rosen, S. D. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.090501.080131 · Cited by 792 · see citing works

Structure and Function of the Cell Surface (Tethered) Mucins

Hattrup, C. L., & Gendler, S. J. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100659 · Cited by 781 · see citing works

Shifting the balance: antibiotic effects on host–microbiota mutualism

Willing, B. P., Russell, S. L., & Finlay, B. B. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2536 · Cited by 747 · see citing works

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

Wlodarska, M., Thaiss, C. A., Nowarski, R., Henao-Mejia, J., Zhang, J.-P., Brown, E. M., Frankel, G., Levy, M., Katz, M. N., Philbrick, W. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.026 · Cited by 708 · see citing works

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

Heazlewood, C. K., Cook, M. C., Eri, R., Price, G. R., Tauro, S. B., Taupin, D., Thornton, D. J., Png, C. W., Crockford, T. L., Cornall, R. J., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050054 · Cited by 701 · see citing works

The composition of the gut microbiota shapes the colon mucus barrier

Jakobsson, H. E., Rodríguez‐Piñeiro, A. M., Schütte, A., Ermund, A., Boysen, P., Bemark, M., Sommer, F., Bäckhed, F., Hansson, G. C., & Johansson, M. E. (2015) · The EMBO Reports · doi:10.15252/embr.201439263 · Cited by 700 · see citing works

The Mucin Degrader Akkermansia muciniphila Is an Abundant Resident of the Human Intestinal Tract

Derrien, M., Collado, M. C., Amor, K. B., Salminen, S., & de Vos, W. M. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01226-07 · Cited by 659 · see citing works

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

Shan, M., Gentile, M., Yeiser, J. R., Walland, A. C., Bornstein, V. U., Chen, K., He, B., Cassis, L., Bigas, A., Cols, M., et al. (2013) · Science · doi:10.1126/science.1237910 · Cited by 642 · see citing works

Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

Bergstrom, K. S. B., Kissoon-Singh, V., Gibson, D. L., Ma, C., Montero, M., Sham, H. P., Ryz, N., Huang, T., Velcich, A., Finlay, B. B., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000902 · Cited by 625 · see citing works

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

Birchenough, G. M. H., Nyström, E. E. L., Johansson, M. E. V., & Hansson, G. C. (2016) · Science · doi:10.1126/science.aaf7419 · Cited by 568 · see citing works

Mucins: A biologically relevant glycan barrier in mucosal protection

Corfield, A. P. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.05.003 · Cited by 567 · see citing works

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

Nowarski, R., Jackson, R. P., Gagliani, N., de Zoete, M. R., Palm, N. W., Bailis, W., Low, J. S., Harman, C. C. D., Graham, M. M., Elinav, E., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.072 · Cited by 564 · see citing works

Normalization of host intestinal mucus layers requires long-term microbial colonization

Johansson, M. E. V., Jakobsson, H. E., Holmén-Larsson, J., Schütte, A., Ermund, A., Rodríguez-Piñeiro, A. M., Arike, L., Wising, C., Svensson, F., Bäckhed, F., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.10.007 · Cited by 549 · see citing works

SYNTHESIS OF THE CARBOHYDRATE OF MUCUS IN THE GOLGI COMPLEX AS SHOWN BY ELECTRON MICROSCOPE RADIOAUTOGRAPHY OF GOBLET CELLS FROM RATS INJECTED WITH GLUCOSE-H3

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Interleukin‐4‐ and interleukin‐13‐mediated host protection against intestinal nematode parasites

Finkelman, F. D., Shea‐Donohue, T., Morris, S. C., Gildea, L. A., Strait, R. T., Madden, K. B., Schopf, L. R., & Urban, J. F. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00192.x · Cited by 515 · see citing works

The outer mucus layer hosts a distinct intestinal microbial niche

Li, H., Limenitakis, J. P., Fuhrer, T., Geuking, M. B., Lawson, M. A., Wyss, M., Brugiroux, S., Keller, I., Macpherson, J. A., Rupp, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9292 · Cited by 511 · see citing works

Epithelial M Cells: Differentiation and Function

Kraehenbühl, J.-P., & Neutra, M. R. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.301 · Cited by 475 · see citing works

Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis.

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Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization.

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Quantitative imaging of gut microbiota spatial organization

Earle, K. A., Billings, G., Sigal, M., Lichtman, J. S., Hansson, G. C., Elias, J. E., Amieva, M. R., Huang, K. C., & Sonnenburg, J. L. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.09.002 · Cited by 433 · see citing works

Deletion of TLR5 results in spontaneous colitis in mice

Vijay–Kumar, M., Sanders, C. J., Taylor, R. T., Kumar, A., Aitken, J. D., Sitaraman, S. V., Neish, A. S., Uematsu, S., Akira, S., Williams, I. R., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci33084 · Cited by 420 · see citing works

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

Park, S.-W., Zhen, G., Verhaeghe, C., Nakagami, Y., Nguyenvu, L. T., Barczak, A. J., Killeen, N. P., & Erle, D. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808722106 · Cited by 418 · see citing works

Increased sensitivity to dextran sodium sulfate colitis in IRE1β-deficient mice

Bertolotti, A., Wang, X.-Z., Novoa, I., Jungreis, R., Schlessinger, K., Cho, J. H., West, A. B., & Ron, D. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11476 · Cited by 412 · see citing works

Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches

Ermund, A., Schutte, A. H., Johansson, M., Gustafsson, J. K., & Hansson, G. C. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00046.2013 · Cited by 392 · see citing works

Antibiotic Treatment Alters the Colonic Mucus Layer and Predisposes the Host to Exacerbated <i>Citrobacter rodentium</i> -Induced Colitis

Wlodarska, M., Willing, B., Keeney, K. M., Menendez, A., Bergstrom, K. S., Gill, N., Russell, S. L., Vallance, B. A., & Finlay, B. B. (2011) · Infection and Immunity · doi:10.1128/iai.01104-10 · Cited by 382 · see citing works

Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model

Johansson, M. E. V., Gustafsson, J. K., Sjöberg, K. E., Petersson, J., Holm, L., Sjövall, H., & Hansson, G. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012238 · Cited by 368 · see citing works

Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

Fu, J., Wei, B., Wen, T., Johansson, M. E. V., Liu, X., Bradford, E., Thomsson, K. A., McGee, S., Mansour, L., Tong, M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45538 · Cited by 366 · see citing works

Butyrate specifically modulates <i>MUC</i> gene expression in intestinal epithelial goblet cells deprived of glucose

Gaudier, E., Jarry, A., Blottière, H. M., de Coppet, P., Buisine, M. P., Aubert, J. P., Laboisse, C., Cherbut, C., & Hoebler, C. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00219.2004 · Cited by 365 · see citing works

Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation

Larsson, J. M. H., Karlsson, H., Crespo, J. G., Johansson, M., Eklund, L., Sjövall, H., & Hansson, G. C. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21625 · Cited by 361 · see citing works

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

Gustafsson, J. K., Ermund, A., Ambort, D., Johansson, M., Nilsson, H. E., Thorell, K., Hebert, H., Sjövall, H., & Hansson, G. C. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20120562 · Cited by 345 · see citing works

Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

Ambort, D., Johansson, M., Gustafsson, J. K., Nilsson, H. E., Ermund, A., Johansson, B. R., Koeck, P. J. B., Hebert, H., & Hansson, G. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120269109 · Cited by 345 · see citing works

Flagella and Chemotaxis Are Required for Efficient Induction ofSalmonella entericaSerovar Typhimurium Colitis in Streptomycin-Pretreated Mice

Stecher, B., Hapfelmeier, S., Müller, C., Kremer, M., Stallmach, T., & Hardt, W. (2004) · Infection and Immunity · doi:10.1128/iai.72.7.4138-4150.2004 · Cited by 339 · see citing works

MUC13, a Novel Human Cell Surface Mucin Expressed by Epithelial and Hemopoietic Cells

Williams, S. J., Wreschner, D. H., Tran, M. H., Eyre, H. J., Sutherland, G. R., & McGuckin, M. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008850200 · Cited by 329 · see citing works

Gel-forming mucins appeared early in metazoan evolution

Lang, T., Hansson, G. C., & Samuelsson, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705984104 · Cited by 317 · see citing works

Spatial organization of bacterial flora in normal and inflamed intestine: A fluorescence<i>in situ</i>hybridization study in mice

Swidsinski, A. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i8.1131 · Cited by 314 · see citing works

Microbial adhesins to gastrointestinal mucus

Juge, N. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.10.001 · Cited by 304 · see citing works

Secreted enteric antimicrobial activity localises to the mucus surface layer

Meyer‐Hoffert, U., Hornef, M. W., Henriques‐Normark, B., Axelsson, L.-G., Midtvedt, T., Pütsep, K., & Andersson, M. (2008) · Gut · doi:10.1136/gut.2007.141481 · Cited by 304 · see citing works

Two novel mucin genes down-regulated in colorectal cancer identified by differential display.

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Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium.

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Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer

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Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon

Knoop, K. A., McDonald, K. G., McCrate, S., Mcdole, J. R., & Newberry, R. D. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.58 · Cited by 276 · see citing works

Mechanism of rapid mucus secretion in goblet cells stimulated by acetylcholine.

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Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

Patel, K., Miyoshi, H., Beatty, W. L., Head, R. D., Malvin, N. P., Cadwell, K., Guan, J., Saitoh, T., Akira, S., Seglen, P. O., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.233 · Cited by 274 · see citing works

Antibiotics promote inflammation through the translocation of native commensal colonic bacteria

Knoop, K. A., McDonald, K. G., Kulkarni, D. H., & Newberry, R. D. (2015) · Gut · doi:10.1136/gutjnl-2014-309059 · Cited by 273 · see citing works

Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin

Nikitas, G., Deschamps, C., Disson, O., Niault, T., Cossart, P., & Lecuit, M. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110560 · Cited by 268 · see citing works

The Ets-Domain Transcription Factor Spdef Promotes Maturation of Goblet and Paneth Cells in the Intestinal Epithelium

Gregorieff, A., Stange, D. E., Kujala, P., Begthel, H., van den Born, M., Korving, J., Peters, P. J., & Clevers, H. C. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.044 · Cited by 263 · see citing works

Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel

Lidell, M. E., Moncada, D. M., Chadee, K., & Hansson, G. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600623103 · Cited by 255 · see citing works

Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice

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Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice

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Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles

Hickey, C., Kuhn, K. A., Donermeyer, D. L., Porter, N. T., Jin, C., Cameron, E. A., Jung, H., Kaiko, G. E., Wegorzewska, M. M., Malvin, N. P., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.002 · Cited by 247 · see citing works

Temporal and spatial interplay of microbiota and intestinal mucosa drive establishment of immune homeostasis in conventionalized mice

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Regulated Airway Goblet Cell Mucin Secretion

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Genomic Cloning, Molecular Characterization, and Functional Analysis of Human CLCA1, the First Human Member of the Family of Ca2+-Activated Cl−Channel Proteins

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Proteomic Analyses of the Two Mucus Layers of the Colon Barrier Reveal That Their Main Component, the Muc2 Mucin, Is Strongly Bound to the Fcgbp Protein

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Mucin Dynamics in Intestinal Bacterial Infection

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